目的

分析南京市2009至2013年手足口病的流行病学特征，以期为进一步制定科学有效的防控策略提供依据。

方法

采用描述性流行病学的研究方法，对南京市2009年至2013年手足口病疫情资料及病原学监测资料进行分析。

结果

2009年至2013年南京市共报告手足口病71 417例，年平均发病率192.55/10万，其中重症患者875例，占病例总数的1.23%。发病数在时间的分布上呈现双峰模式，4至7月为全年主高峰，11至12月为全年次高峰。主城区、近郊和远郊的发病率具有显著性差异，主城区发病率最低（χ²＝3 077.58，P＜0.01）。男女发病率之比为1.5∶1，男性发病率显著高于女性发病率（χ² ＝1 907.79，P＜0.01）。0～5岁儿童发病数最多，占病例总数的98.72%，并且0～9岁各年龄组间的发病率具有显著性差异（χ²＝53 289.79，P＜0.01）。病例的职业分布以散居儿童最多，其次为幼托儿童，两者共占总病例数的95.75%。2009年至2013年共报告诊断病例1 670例，病原体以EV71和Cox A16感染为主。

结论

南京市手足口病在时间、地区、性别、年龄以及职业分布具有一定的特征，对于低年龄、男性儿童、散居儿童以及幼托儿童这类重点人群的防控应该着重关注。

Objective

To analyze the epidemiological characteristics of hand-foot-mouth disease（HFMD）in Nanjing from 2009 to 2013 so as to provide the basis for further formulating scientific and effective prevention and control strategies.

Methods

Descriptive epidemiology research method was conducted to analyze the epidemiological and etiological data of HFMD in Nanjing from 2009 to 2013.Results There reported 71 417 HFMD cases from 2009 to 2013，with average annual incidence of 192.55 per 10，0000 and 875 severe cases，accounting for 1.23% of the total.The incidence was distributed in a bimodal pattern，with the main peak from April to July and the sub peak from November to December in one year.The incidences in the central districts differed significantly from that in the suburbs and the outer suburbs，with the lowest incidence in the central district（P＜0.001）.The ratio of male to female was 1.5∶1，with significantly higher incidence of males than females（P＜0.001）.The children aged from 0 to 5 years accounted for 98.72%，and the incidences were significantly different in different age groups from 0 to 9（P＜0.001）.Most of the patients were scattered children and kindergarten children，accounting for 95.75 percent of the total.A total of 1 670 cases were confirmed from2009 to2013，with EV71 and CoxA16 as the most commonly seen pathogens.

Conclusions

The incidence of HFMD in Nanjing has specific distribution features in terms of different seasons，regions，gender，age and occupations.We should pay more attention to those including younger aged，boys，scattered and kindergarten children to take reasonable prevention and control measures.Further epidemiological and etiological researches may provide more powerful evidences for prevention and control of HFMD.