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中华卫生应急电子杂志 ›› 2016, Vol. 02 ›› Issue (02) : 69 -73. doi: 10.3877/cma.j.issn.2095-9133.2016.02.001

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埃博拉病毒病的发病机制和诊疗策略
周飞虎1,(), 胡婕1   
  1. 1. 100853 北京,解放军总医院重症医学科
  • 收稿日期:2016-02-13 出版日期:2016-04-18
  • 通信作者: 周飞虎

Pathogenesis, diagnosis and treatment strategy of Ebola virus disease

Feihu Zhou1,(), Jie Hu1   

  1. 1. Department of Critical Medicine, General Hospital of PLA, Beijing 100853, China
  • Received:2016-02-13 Published:2016-04-18
  • Corresponding author: Feihu Zhou
  • About author:
    Corresponding author: Zhou Feihu, Email:
引用本文:

周飞虎, 胡婕. 埃博拉病毒病的发病机制和诊疗策略[J]. 中华卫生应急电子杂志, 2016, 02(02): 69-73.

Feihu Zhou, Jie Hu. Pathogenesis, diagnosis and treatment strategy of Ebola virus disease[J]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2016, 02(02): 69-73.

埃博拉病毒是一种强致死性病原体,可引起类似于感染性休克的严重出血热——埃博拉病毒病。埃博拉病毒病在2014年西非地区发生历史上最大的大流行疫情,其临床特点为凝血功能障碍、毛细血管渗漏综合征和休克。迄今为止尚无针对性抗病毒药物治疗。本文从病原学、感染途径、发病机制、临床特征、辅助检查、诊断及治疗特点等方面探讨埃博拉病毒病的机制和诊疗策略。

Ebola virus (EBV) is a fatal microorganism leading to septic shock-like hemorrhagic fevers in humans and non-human primates, referred as Ebola virus disease (EVD). The outbreak in west Africa in 2014 has affected more people than all previous outbreaks combined. EVD was characterized by coagulopathy, capillary leak syndrome and shock. To date, there was no specific antivirus medication. In this manuscript, we discuss the pathogenesis and therapeutic strategy for EVD from aspectsof etiology, epidemiology, pathophysiology, clinical characteristics, lab tests, diagnosis and treatment.

图1 EVD可能出现的全身症状[19]
表1 EVD病原学治疗药物临床试验[19]
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