1 |
Loewith R, Jacinto E, Wullschleger S, et al.Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control[J]. Mol Cell, 2002, 10(3): 457-468.
|
2 |
Chiang GG, Abraham RT.Targeting the mTOR signaling network in cancer[J]. Trends Mol Med, 2007, 13(10): 433-442.
|
3 |
Hara K, Maruki Y, Long X, et al.Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action[J]. Cell, 2002, 110(2): 177-189.
|
4 |
Sarbassov DD, Ali SM, Kim DH, et al.Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton[J]. Curr Biol, 2004, 14(14): 1296-1302.
|
5 |
Frias MA, Thoreen CC, Jaffe JD, et al.mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s[J]. Curr Biol, 2006, 16(18): 1865-1870.
|
6 |
Pearce LR, Huang X, Boudeau J, et al.Identification of Protor as a novel Rictor-binding component of mTOR complex-2[J]. Biochem J, 2007, 405(405): 513-522.
|
7 |
Sarbassov DD, Ali SM, Sengupta S, et al.Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB[J]. Mol Cell, 2006, 22(2): 159-168.
|
8 |
Guertin DA, Sabatini DM.Defining the role of mTOR in cancer[J]. Cancer Cell, 2007, 12(1): 9-22.
|
9 |
Jacinto E, Loewith R, Schmidt A, et al.Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive[J]. Nat Cell Biol, 2004, 6(11): 1122-1128.
|
10 |
Choo AY, Yoon SO, Kim SG, et al.Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation[J]. Proc Natl Acad Sci USA, 2008, 105(45): 17414-17419.
|
11 |
Gwinn DM, Shackelford DB, Egan DF, et al.AMPK phosphorylation of raptor mediates a metabolic checkpoint[J]. Mol Cell, 2008, 30(2): 214-226.
|
12 |
Inoki K, Zhu T, Guan KL.TSC2 mediates cellular energy response to control cell growth and survival[J]. Cell, 2003, 115(5): 577-590.
|
13 |
Gingras AC, Raught B, Sonenberg N. Regulation of translation initiation by FRAP/mTOR[J]. Genes Dev, 2001, 15(7): 807-826.
|
14 |
Shimada H, Hirai K, Simamura E, et al.Paraquat toxicity induced by voltage-dependent anion channel 1 acts as an NADH-dependent oxidoreductase[J]. J Biol Chem, 2009, 284(42): 28642-28649.
|
15 |
梁敏锐.肺纤维化过程中肌成纤维细胞活化的调控机制及干预研究[D].上海:复旦大学,2013.
|
16 |
邵雪.雷帕霉素治疗小鼠百草枯中毒致肺纤维化的作用及机制研究[D].杭州:浙江大学,2015.
|
17 |
万安霞.加减补肺汤对博来霉素诱导小鼠肺纤维化干预作用的实验研究[D].武汉:湖北中医药大学,2015.
|
18 |
王密琳.煤工尘肺患者肺巨噬细胞自噬活动研究[D].唐山:河北联合大学,2014.
|
19 |
Gui YS, Wang L, Tian X, et al.mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary Fibrosis[J]. PLoS One, 2015, 10(9): e0138625.
|
20 |
Patel AS, Lin L, Geyer A, et al.Autophagy in idiopathic pulmonary fibrosis[J]. PloS one, 2012, 7(7): e41394.
|
21 |
White ES, Sagana RL, Booth AJ, et al.Control of fibroblast fibronectin expression and alternative splicing via the PI3K/Akt/mTOR pathway[J]. Exp Cell Res, 2010, 316(16): 2644-2653.
|
22 |
Morgan TH.The theory of the gene[J]. American Naturalist, 1917, 51(609): 513-544.
|
23 |
Artavanis-Tsakonas S, Matsuno K, Fortini ME.Notch signaling[J]. Science, 1995, 268(5208): 225-232.
|
24 |
Koch U, Radtke F. Chapter Thirteen - Notch Signaling in Solid Tumors[J]. Curr Topics Dev Biol, 2010, 92(6): 411-455.
|
25 |
Miele L. Notch signaling[J]. Clin Cancer Res, 2006, 12(12): 1074-1079.
|
26 |
Carlson ME, Conboy IM.Regulating the Notch pathway in embryonic, adult and old stem cells[J]. Curr Opin Pharmacol, 2007, 7(3): 303-309.
|
27 |
Fiúza UM, Arias AM.Cell and molecular biology of Notch[J]. The Journal of endocrinology, 2007, 194(3): 459-474.
|
28 |
Jarriault S, Brou C, Logeat F, et al.Signalling downstream of activated mammalian Notch[J]. Nature, 1995, 377(6547): 355-358.
|
29 |
Nam Y, Aster JC, Blacklow SC.Notch signaling as a therapeutic target[J]. Current Opinion in Chemical Biology, 2002, 6(4): 501-509.
|
30 |
Takasugi N, Tomita T, Hayashi I, et al.The role of presenilin cofactors in the gamma-secretase complex[J]. Nature, 2003, 422(6930): 438-441.
|
31 |
Kovall RA.Structures of CSL, Notch and Mastermind proteins: piecing together an active transcription complex[J]. Curr Opin Struct Biol, 2007, 17(1): 117-127.
|
32 |
Martinez Arias A, Zecchini V, Brennan K. CSL-independent Notch signalling: a checkpoint in cell fate decisions during development?[J]. Curr Opin Genet Dev, 2002, 12(5): 524-533.
|
33 |
Yamamoto N, Yamamoto S, Inagaki F, et al.Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor[J]. J Biol Chem, 2001, 276(48): 45031-45040.
|
34 |
Aoyagi-Ikeda K, Maeno T, Matsui H, et al.Notch induces myofibroblast differentiation of alveolar epithelial cells via transforming growth factor-{beta}-Smad3 pathway[J]. Am J Respir Cell Mol Biol, 2011, 45(1): 136-144.
|
35 |
Plantier L, Crestani B, Wert SE, et al.Ectopic respiratory epithelial cell differentiation in bronchiolised distal airspaces in idiopathic pulmonary fibrosis[J]. Thorax, 2011, 66(8): 651-657.
|
36 |
Kavian N, Servettaz A, Mongaret C, et al.Targeting ADAM-17/notch signaling abrogates the development of systemic sclerosis in a murine model[J]. Arthritis Rheum, 2010, 62(11): 3477-3487.
|
37 |
Ostroukhova M, Qi Z, Oriss TB, et al.Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-beta[J]. J Clin Invest, 2006, 116(4): 996-1004.
|
38 |
Fitau J, Boulday G, Coulon F, et al.The adaptor molecule Lnk negatively regulates tumor necrosis factor-alpha-dependent VCAM-1 expression in endothelial cells through inhibition of the ERK1 and -2 pathways[J]. J Biol Chem, 2006, 281(29): 20148-20159.
|
39 |
Liu T, Hu B, Choi YY, et al.Notch1 signaling in FIZZ1 induction of myofibroblast differentiation[J]. Am J Pathol, 2009, 174(5): 1745-1755.
|
40 |
Piggott K, Deng J, Warrington K, et al.Blocking the NOTCH pathway inhibits vascular inflammation in large-vessel vasculitis[J]. Circulation, 2011, 123(3): 309-318.
|
41 |
Wang Q, Li DC, Li ZF, et al.Upregulation of miR-27a contributes to the malignant transformation of human bronchial epithelial cells induced by SV40 small T antigen[J]. Oncogene, 2011, 30(36): 3875-3886.
|
42 |
Nusse R, Varmus HE.Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome[J]Cell, 1982, 31(1): 99-109.
|
43 |
Nusse R, Brown A, Papkoff J, et al.A new nomenclature for int-1 and related genes: the Wnt gene family[J]. Cell, 1991, 64(2): 231.
|
44 |
Gordon MD, Nusse R. Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors[J]. J Biol Chem, 2006, 281(32): 22429-22433.
|
45 |
Van De Schans VA, Smits JF, Blankesteijn WM.The Wnt/frizzled pathway in cardiovascular development and disease: friend or foe?[J]. Eur J Pharmacol, 2008, 585(2-3): 338-345.
|
46 |
Niehrs C. The complex world of WNT receptor signalling[J]. Nat Rev Mol Cell Biol, 2012, 13(12): 767-779.
|
47 |
Kikuchi A, Yamamoto H, Kishida S. Multiplicity of the interactions of Wnt proteins and their receptors[J]. Cell Signal, 2007, 19(4): 659-671.
|
48 |
Xing Y, Clements W K, Kimelman D, et al.Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex[J]. Genes Dev, 2003, 17(22): 2753-2764.
|
49 |
Willert K, Nusse R. Beta-catenin: a key mediator of Wnt signaling[J]. Current opinion in genetics & development, 1998, 8(1): 95-102.
|
50 |
Logan CY, Nusse R. The Wnt signaling pathway in development and disease[J]. Annu Rev Cell Dev Biol, 2004, 20: 781-810.
|
51 |
Zeng X, Tamai K, Doble B, et al.A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation[J]. Nature, 2005, 438(7069): 873-877.
|
52 |
Li VS, Ng SS, Boersema PJ, et al.Wnt signaling through inhibition of beta-catenin degradation in an intact Axin1 complex[J]. Cell, 2012, 149(6): 1245-1256.
|
53 |
Van Amerongen R, Nusse R. Towards an integrated view of Wnt signaling in development[J]. Development, 2009, 136(19): 3205-3214.
|
54 |
Kulikova KV, Posviatenko AV, Gnuchev NV, et al.[Nuclear beta-catenin localization is not sufficient for canonical Wnt signaling activation in human meianoma cell lines][J]. Mol Biol(Mosk), 2011, 45(5): 884-891.
|
55 |
Graham TA, Weaver C, Mao F, et al.Crystal structure of a beta-catenin/Tcf complex[J]. Cell, 2000, 103(6): 885-896.
|
56 |
Mosimann C, Hausmann G, Basler K. Beta-catenin hits chromatin: regulation of Wnt target gene activation[J]. Nat Rev Mol Cell Biol, 2009, 10(4): 276-286.
|
57 |
Kim TH, Kim SH, Seo JY, et al.Blockade of the Wnt/beta-catenin pathway attenuates bleomycin-induced pulmonary fibrosis[J]. Tohoku J Exp Med, 2011, 223(1): 45-54.
|
58 |
Raghu G, Rochwerg B, Zhang Y, et al.An Official ATS/ERS/JRS/ALAT clinical practice guideline: treatment of idiopathic pulmonary fibrosis.An update of the 2011 clinical practice guideline[J]. Am J Respir Crit Care Med, 2015, 192(2): e3-19.
|
59 |
Park S, Lee EJ.Recent advances in idiopathic pulmonary fibrosis[J]. Tuberc Respir Dis(Seoul), 2013, 74(1): 1-6.
|
60 |
Konigshoff M, Kramer M, Balsara N, et al.WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis[J]. J Clin Invest, 2009, 119(4): 772-787.
|
61 |
Chilosi M, Poletti V, Zamò A, et al.Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis[J]. Am J Pathol, 2003, 162(5): 1495-1502.
|
62 |
Uhal BD, Joshi I, Hughes WF, et al.Alveolar epithelial cell death adjacent to underlying myofibroblasts in advanced fibrotic human lung[J]. Am J Physiol, 1998, 275(6Pt1): L1192-L1199.
|
63 |
Uhal BD, Joshi I, True AL, et al.Fibroblasts isolated after fibrotic lung injury induce apoptosis of alveolar epithelial cells in vitro[J]. Am J Physiol, 1995, 269(6 Pt 1): L819-L828.
|
64 |
Selman M, Ruiz V, Cabrera S, et al.TIMP-1, -2, -3, and -4 in idiopathic pulmonary fibrosis.A prevailing nondegradative lung microenvironment?[J]. Am J Physiol Lung Cell Mol Physiol, 2000, 279(3): L562-574.
|
65 |
Kaminski N, Rosas IO.Gene expression profiling as a window into idiopathic pulmonary fibrosis pathogenesis: can we identify the right target genes?[J]. Proc Am Thorac Soc, 2006, 3(4): 339-344.
|
66 |
Liu L, Carron B, Yee HT, et al.Wnt pathway in pulmonary fibrosis in the bleomycin mouse model[J]. J Environ Pathol Toxicol Oncol, 2009, 28(2): 99-108.
|
67 |
Königshoff M, Balsara N, Pfaff E M, et al.Functional Wnt signaling is increased in idiopathic pulmonary fibrosis[J]. PLoS One, 2008, 3(5): e2142.
|
68 |
Pfaff EM, Becker S, Gunther A, et al.Dickkopf proteins influence lung epithelial cell proliferation in idiopathic pulmonary fibrosis[J]. Eur Respir J, 2011, 37(1): 79-87.
|
69 |
Lam AP, Flozak AS, Russell S, et al.Nuclear β-Catenin Is Increased in Systemic Sclerosis Pulmonary Fibrosis and Promotes Lung Fibroblast Migration and Proliferation [J]. Am J Respir Cell Mol Biol, 2011, 45(5): 915-922.
|
70 |
Nusslein-Volhard C, Wieschaus EF.Mutations affecting segment number and polarity in Drosophila[J]. Nature, 1980, 287(5785): 795-801.
|
71 |
Mohler J. Requirements for hedgehog, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila[J]. Genetics, 1988, 120(4): 1061-1072.
|
72 |
Forbes AJ, Nakano Y, Taylor AM, et al.Genetic analysis of hedgehog signalling in the Drosophila embryo[J]. Dev Suppl, 1993: 115-124.
|
73 |
Ingham PW, Mcmahon AP.Hedgehog signaling in animal development: paradigms and principles[J]. Genes Dev, 2001, 15(23): 3059-3087.
|
74 |
Ingham PW, Nakano Y, Seger C. Mechanisms and functions of Hedgehog signalling across the metazoa[J]. Nat Rev Genet, 2011, 12(6): 393-406.
|
75 |
Taipale J, Beachy PA.The Hedgehog and Wnt signalling pathways in cancer[J]. Nature, 2001, 411(6835): 349-354.
|
76 |
Pan Y, Wang B. A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome[J]. J Biol Chem, 2007, 282(15): 10846-10852.
|
77 |
Porter JA, Von Kessler DP, Ekker SC, et al.The product of hedgehog autoproteolytic cleavage active in local and long-range signalling[J]. Nature, 1995, 374(6520): 363-366.
|
78 |
Porter JA, Ekker SC, Park WJ, et al.Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain[J]. Cell, 1996, 86(1): 21-34.
|
79 |
Lee JJ, Ekker SC, Von Kessler DP, et al.Autoproteolysis in hedgehog protein biogenesis[J]. Science, 1994, 266(5190): 1528-1537.
|
80 |
Porter JA, Young KE, Beachy PA.Cholesterol modification of hedgehog signaling proteins in animal development[J]. Science, 1996, 274(5285): 255-259.
|
81 |
Chen X, Tukachinsky H, Huang CH, et al.Processing and turnover of the Hedgehog protein in the endoplasmic reticulum[J]. J Cell Biol, 2011, 192(5): 825-838.
|
82 |
Buglino JA, Resh MD.Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog[J]. J Biol Chem, 2008, 283(32): 22076-22088.
|
83 |
Zhu AJ, Scott MP.Incredible journey: how do developmental signals travel through tissue?[J]. Genes Dev, 2004, 18(24): 2985-2997.
|
84 |
Burke R, Nellen D, Bellotto M, et al.Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells[J]. Cell, 1999, 99(7): 803-815.
|
85 |
Gallet A. Hedgehog morphogen: from secretion to reception[J]. Trends Cell Biol, 2011, 21(4): 238-246.
|
86 |
Chen MH, Li YJ, Kawakami T, et al.Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates[J]. Genes Dev, 2004, 18(6): 641-659.
|
87 |
Eugster C, Panáková D, Mahmoud A, et al.Lipoprotein-heparan sulfate interactions in the Hh pathway[J]. Dev Cell, 2007, 13(1): 57-71.
|
88 |
Dierker T, Dreier R, Petersen A, et al.Heparan sulfate-modulated, metalloprotease-mediated sonic hedgehog release from producing cells[J]. J Biol Chem, 2009, 284(12): 8013-8022.
|
89 |
Guerrero I, Chiang C. A conserved mechanism of Hedgehog gradient formation by lipid modifications[J]. Trends Cell Biol, 2007, 17(1): 1-5.
|
90 |
Pepinsky RB, Zeng C, Wen D, et al.Identification of a palmitic acid-modified form of human Sonic hedgehog[J]. J Biol Chem, 1998, 273(22): 14037-14045.
|
91 |
Chamoun Z, Mann RK, Nellen D, et al.Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal[J]. Science, 2001, 293(5537): 2080-2084.
|
92 |
Routh MD, Zalucki Y, Su CC, et al.Efflux pumps of the resistance-nodulation-division family: a perspective of their structure, function, and regulation in gram-negative bacteria[J]. Adv Enzymol Relat Areas Mol Biol, 2011, 77: 109-146.
|
93 |
Allen BL, Song JY, Izzi L, et al.Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function[J]. Dev Cell, 2011, 20(6): 775-787.
|
94 |
Taipale J, Cooper MK, Maiti T, et al.Patched acts catalytically to suppress the activity of Smoothened[J]. Nature, 2002, 418(6900): 892-897.
|
95 |
Rohatgi R, Milenkovic L, Scott MP.Patched1 regulates hedgehog signaling at the primary cilium[J]. Science, 2007, 317(5836): 372-376.
|
96 |
Wang Y, Zhou Z, Walsh CT, et al.Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation[J]. Proc Natl Acad Sci U S A, 2009, 106(8): 2623-2628.
|
97 |
Chen JK, Taipale J, Young KE, et al.Small molecule modulation of Smoothened activity[J]. Proc Natl Acad Sci U S A, 2002, 99(22): 14071-14076.
|
98 |
Chen Y, Sasai N, Ma G, et al.Sonic Hedgehog dependent phosphorylation by CK1alpha and GRK2 is required for ciliary accumulation and activation of smoothened[J]. PLoS Biol, 2011, 9(6): e1001083.
|
99 |
Milenkovic L, Scott MP Rohatgi R. Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium[J]. J Cell Biol, 2009, 187(3): 365-374.
|
100 |
Stewart GA, Hoyne GF, Ahmad SA, et al.Expression of the developmental Sonic hedgehog (Shh) signalling pathway is up-regulated in chronic lung fibrosis and the Shh receptor patched 1 is present in circulating T lymphocytes[J]. J Pathol, 2003, 199(4): 488-495.
|
101 |
Kasper M, Haroske G. Alterations in the alveolar epithelium after injury leading to pulmonary fibrosis[J]. Histol Histopathol, 1996, 11(2): 463-483.
|
102 |
Khalil N, O'connor RN, Flanders KC, et al.TGF-beta 1, but not TGF-beta 2 or TGF-beta 3, is differentially present in epithelial cells of advanced pulmonary fibrosis: an immunohistochemical study[J]. Am J Respir Cell Mol Biol, 1996, 14(2): 131-138.
|
103 |
Levine D, Rockey DC, Milner TA, et al.Expression of the integrin alpha8beta1 during pulmonary and hepatic fibrosis[J]. Am J Pathol, 2000, 156(6): 1927-1935.
|
104 |
Bellusci S, Furuta Y, Rush MG, et al.Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis[J]. Development, 1997, 124(1): 53-63.
|
105 |
Weaver M, Batts L, Hogan BL.Tissue interactions pattern the mesenchyme of the embryonic mouse lung[J]. Dev Biol, 2003, 258(1): 169-184.
|
106 |
Liu L, Kugler MC, Loomis CA, et al.Hedgehog signaling in neonatal and adult lung[J]. Am J Respir Cell Mol Biol, 2013, 48(6): 703-710.
|
107 |
Coon DR, Roberts DJ, Loscertales M, et al.Differential epithelial expression of SHH and FOXF1 in usual and nonspecific interstitial pneumonia[J]. Exp Mol Pathol, 2006, 80(2): 119-123.
|
108 |
Bolanos AL, Milla CM, Lira JC, et al.Role of Sonic Hedgehog in idiopathic pulmonary fibrosis[J]. Am J Physiol Lung Cell Mol Physiol, 2012, 303(11): L978-L990.
|
109 |
Horn A, Palumbo K, Cordazzo C, et al.Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis[J]. Arthritis Rheum, 2012, 64(8): 2724-2733.
|
110 |
Tuder RM.A pathologist's approach to interstitial lung disease[J]. Curr Opin Pulm Med, 1996, 2(5): 357-363.
|
111 |
Katoh M, Katoh M. Human FOX gene family(Review)[J]. Int J Oncol, 2004, 25(5): 1495-1500.
|
112 |
Tseng HT, Shah R, Jamrich M. Function and regulation of FoxF1 during Xenopus gut development[J]. Development, 2004, 131(15): 3637-3647.
|
113 |
Roberts AB, Lamb LC, Newton DL, et al.Transforming growth factors: isolation of polypeptides from virally and chemically transformed cells by acid/ethanol extraction[J]. Proc Natl Acad Sci U S A, 1980, 77(6): 3494-3498.
|
114 |
De Larco JE, Todaro GJ.Growth factors from murine sarcoma virus-transformed cells[J]. Proc Natl Acad Sci U S A, 1978, 75(8): 4001-4005.
|
115 |
Brodin G, Ten Dijke P, Funa K, et al.Increased smad expression and activation are associated with apoptosis in normal and malignant prostate after castration[J]. Cancer Res, 1999, 59(11): 2731-2738.
|
116 |
Wu MY, Hill CS.Tgf-beta superfamily signaling in embryonic development and homeostasis[J]. Dev Cell, 2009, 16(3): 329-343.
|
117 |
牛秀珑,王越,梁国庆.转化生长因子β的研究进展[J].医学综述,2004,10(4):209-210.
|
118 |
Liu T, Feng XH.Regulation of TGF-beta signalling by protein phosphatases[J]. Biochem J, 2010, 430(2): 191-198.
|
119 |
Kirsch T, Sebald W, Dreyer MK.Crystal structure of the BMP-2-BRIA ectodomain complex[J]. Nat Struct Biol, 2000, 7(6): 492-496.
|
120 |
Massague J. TGF-beta signal transduction[J]. Annu Rev Biochem, 1998, 67: 753-791.
|
121 |
Hart PJ, Deep S, Taylor AB, et al.Crystal structure of the human TbetaR2 ectodomain——TGF-beta3 complex[J]. Nat Struct Biol, 2002, 9(3): 203-208.
|
122 |
Taylor AW.Review of the activation of TGF-beta in immunity[J]. Journal of leukocyte biology, 2009, 85(1): 29-33.
|
123 |
Sekelsky JJ, Newfeld SJ, Raftery LA, et al.Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster[J]. Genetics, 1995, 139(3): 1347-1358.
|
124 |
Derynck R, Gelbart WM, Harland RM, et al.Nomenclature: vertebrate mediators of TGFbeta family signals[J]. Cell, 1996, 87(2): 173.
|
125 |
Dennler S, Goumans M J, Ten Dijke P. Transforming growth factor beta signal transduction[J]. J Leukoc Biol, 2002, 71(5): 731-740.
|
126 |
Imamura T, Takase M, Nishihara A, et al.Smad6 inhibits signalling by the TGF-beta superfamily[J]. Nature, 1997, 389(6651): 622-626.
|
127 |
Nakao A, Afrakhte M, Moren A, et al.Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling[J]. Nature, 1997, 389(6651): 631-635.
|
128 |
Miyazawa K, Shinozaki M, Hara T, et al.Two major Smad pathways in TGF-beta superfamily signalling[J]. Genes Cells, 2002, 7(12): 1191-1204.
|
129 |
Wu G, Chen YG, Ozdamar B, et al.Structural basis of Smad2 recognition by the Smad anchor for receptor activation[J]. Science, 2000, 287(5450): 92-97.
|
130 |
Chen YG, Hata A, Lo R S, et al.Determinants of specificity in TGF-beta signal transduction[J]. Genes Dev, 1998, 12(14): 2144-5212.
|
131 |
Lin X, Duan X, Liang YY, et al.PPM1A Functions as a Smad Phosphatase to Terminate TGFbeta Signaling[J]. Cell, 2016, 166(6): 1597.
|
132 |
Wilson MS, Wynn TA.Pulmonary fibrosis: pathogenesis, etiology and regulation[J]. Mucosal Immunol, 2009, 2(2): 103-121.
|
133 |
Dennler S, Itoh S, Vivien D, et al.Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene[J]. Embo j, 1998, 17(11): 3091-3100.
|
134 |
Senoo T, Hattori N, Tanimoto T, et al.Suppression of plasminogen activator inhibitor-1 by RNA interference attenuates pulmonary fibrosis[J]. Thorax, 2010, 65(4): 334-340.
|
135 |
Piek E, Heldin CH, Ten Dijke P. Specificity, diversity, and regulation in TGF-beta superfamily signaling[J]. FASEB J, 1999, 13(15): 2105-2124.
|
136 |
Giri SN, Hyde DM, Hollinger MA.Effect of antibody to transforming growth factor beta on bleomycin induced accumulation of lung collagen in mice[J]. Thorax, 1993, 48(10): 959-966.
|
137 |
Eickelberg O, Laurent GJ.The quest for the initial lesion in idiopathic pulmonary fibrosis: gene expression differences in IPF fibroblasts[J]. Am J Respir Cell Mol Biol, 2010, 42(1): 1-2.
|
138 |
Scotton CJ, Chambers RC.Molecular targets in pulmonary fibrosis: the myofibroblast in focus[J]. Chest, 2007, 132(4): 1311-1321.
|