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中华卫生应急电子杂志

中华卫生应急电子杂志 ›› 2018, Vol. 04 ›› Issue (06) : 354 -357. doi: 10.3877/cma.j.issn.2095-9133.2018.06.008

所属专题： 文献；

论著

倍他司汀联合Brandt-Daroff习服训练治疗主观性良性阵发性位置性眩晕的疗效观察
史红娟1, 郝冬琳1,†(), 毛伦林1   
  1. 1. 213017　江苏常州，江苏大学附属武进医院神经内科
  • 收稿日期:2018-11-09 出版日期:2018-12-18
  • 通信作者: 郝冬琳

Curative effect of betahistine combined with Brandt-Daroff exercise in the treatment of subjective benign paroxysmal positional vertigo

Hongjuan Shi1, Donglin Hao1,†(), Lunlin Mao1   

  1. 1. Department of Neurology, Wujin Hospital Affiliated to Jiangsu University, Changzhou 213017, China
  • Received:2018-11-09 Published:2018-12-18
  • Corresponding author: Donglin Hao
  • About author:
    Corresponding author: Hao Donglin, Email:
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史红娟, 郝冬琳, 毛伦林. 倍他司汀联合Brandt-Daroff习服训练治疗主观性良性阵发性位置性眩晕的疗效观察[J]. 中华卫生应急电子杂志, 2018, 04(06): 354-357.

Hongjuan Shi, Donglin Hao, Lunlin Mao. Curative effect of betahistine combined with Brandt-Daroff exercise in the treatment of subjective benign paroxysmal positional vertigo[J]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2018, 04(06): 354-357.

目的

评估倍他司汀联合Brandt-Daroff习服训练治疗主观性良性阵发性位置性眩晕(S-BPPV)的疗效。

方法

选取2012年1月至2017年12月江苏大学附属武进医院神经内科收治的90例符合S-BPPV的患者为研究对象，其中男性27例，女性63例；年龄为38～84岁，平均年龄(61.19±12.18)岁。所有患者采用随机数字表法随机分为药物组(倍他司汀药物治疗)40例和联合组(倍他司汀联合Brandt-Daroff习服训练治疗)50例。对两组患者治疗1周、2周、3周后的有效率进行比较。

结果

联合组治疗S-BPPV患者1周、2周、3周后的的总有效率均高于药物治疗组(P<0.05)，药物组3周后有3例患者复发。

结论

倍他司汀联合Brandt-Daroff习服训练治疗S-BPPV的总有效率优于单一药物治疗，并且可以降低S-BPPV的短期复发率。

关键词: 倍他司汀, 良性阵发性位置性眩晕, Brandt-Daroff训练法, 主观性
Objective

To evaluate the efficacy of Betastatin combined with Brandt-Daroff exercisetreatedthe subjective benign paroxysmal positional vertigo(S-BPPV).

Methods

A prospective study was conducted on 90 patients with s-bppv who were admitted to the department of neurology of Wujin Hospital Affiliated to Jiangsu University from January 2012 to December 2017. Among them, there were 27 males and 63 females, whose age ranged from 38 to 84 years withthe average age of 61.19 ±12.18 years. The patients were randomly divided into two groups by random number table method, the Betastatin drug treatment group (40 cases), the drug treatment combined Brandt-Daroff exercise treatment group (50 cases). The curative effects were observed after 1 weeks, 2 weeks and 3 weeks respectively.

Results

The total effective rate of Betastatin combined with Brandt-Daroff exercise in the treatment of S-BPPV was higher than the drug treatment group (P<0.05 after 1 weeks, 2 weeks and 3 weeks. There were 3 cases (7.50%) patients relapse in the drug treatment group after 3 weeks.

Conclusion

The total effective rate of Betastatin combined with Brandt-Daroff exercise treated the S-BPPV was better than the drug treatment, and it can also reduce the short-term recurrence rate of the S-BPPV.

Key words: Betastatin, Benign paroxysmal positional vertigo, Brandt-Daroff exercise, Subjective
表1 两组治疗方案的患者基线资料情况比较
组别 例数 年龄(岁，±s) 男性[例(%)] 病程(d，±s)
药物组 40 60.45±11.42 10(25.00) 6.50±2.70
联合组 50 61.78±13.11 17(34.00) 6.74±2.39
t/χ2值 ? 0.51 0.86 0.45
P值 ? >0.05 >0.05 >0.05
表2 两组方法治疗S-BPPV不同时间治疗效果比较[例(%)]
组别 例数 治愈 有效 无效 总有效率(%)
药物组(1周后) 40 6(15.00) 5(12.50) 29(72.50) 11(27.50)
联合组(1周后) 50 20(40.00) 5(10.00) 25(50.00) 25(50.00)
t/χ2值 ? ? ? ? 4.69
P值 ? ? ? ? <0.05
组别 例数 治愈 有效 无效 总有效率(%)
药物组(2周后) 40 10(25.00) 10(25.00) 20(50.00) 20(50.00)
联合组(2周后) 50 25(50.00) 12(24.00) 13(26.00) 37(74.00)
t/χ2值 ? ? ? ? 5.51
P值 ? ? ? ? <0.05
组别 例数 治愈 有效 无效 总有效率(%)
药物组(3周后) 40 9(22.50) 8(20.00) 23(57.50) 17(42.50)
联合组(3周后) 50 29(58.00) 12(24.00) 9(18.00) 41(82.00)
t/χ2值 ? ? ? ? 15.13
P值 ? ? ? ? <0.05
1
Karatas M. Central vertigo and dizziness：epidemiology, differential diagnosis, and common causes[J]. Neurologist, 2008, 14(6): 355-364.
2
Strupp M, Dieterich M, Brandt T. The treatment and natural course of peripheral and central vertigo[J]. Dtsch Arztebl Int, 2013, 110 (29-30): 505-515.
3
Haynes DS, Resser JR, Labadie RF, et al.Treatment of benign positional vertigo using the semontmaneuver：efficacy in patients presenting without nystagmus[J]. Laryngoscope, 2002, 112(5): 796-801.
4
Tirelli G, D’Orlando E, Giacomarra V, et al.Benign positional vertigo without detectable nystagmus[J]. Laryngoscope, 2001, 111(6): 1053-1056.
5
Simhadri S, Panda N, Raghunathan M. Efficacy of particle repositioning maneuver in BPPV：a prospective study[J]. Am J Otolaryngol, 2003, 24(6): 355-360.
6
von Brevern M, Seelig T, Radtke A, et al.Short term efficacy of Epley’smanoeuvre：a double-blind randomised trial[J]. J Neurol Neurosurg Psychiatry, 2006, 77(8): 980-982.
7
赵慧贤，刘鑫国，田永远，等. 主观性良性阵发性位置性眩晕临床研究[J]. 中国耳鼻咽喉头颈外科，2016，23(12): 700-701.
8
张波，孙敬武. 良性阵发性位置性眩晕患者裸眼及视频眼震图下眼震特征及定位诊断分析[J]. 听力学及言语疾病杂志，2012，20(3): 235-237.
9
中华耳鼻咽喉头颈外科杂志编辑委员会，中华医学会耳鼻咽喉科学分会. 良性阵发性位置性眩晕的诊断依据和疗效评估(2006年，贵阳)[J]. 中华耳鼻咽喉头颈外科杂志，2007，42(3): 163-164.
10
von Brevem M, Radtke A, Lezius F, et a1.Epidemiology of benign pamxysmal positional vertigo: a population based study[J]. J Neurol Neurosurg Psychiatry, 2007, 78(7): 7l0-715.
11
Prokopakis EP, Chimona T, Tsagoumisakis M, et al.Benign paroxysmal positional vertigo：10-year experience in treating 592 patients with canalithrepositioning procedure[J]. Laryngoscope, 2005, 115(9): 1667-1671.
12
Cakir BO, Ercan I, Cakir ZA, et al.What is the true incidence ofhorizontal semicircular canal benign paroxysmal positional vertigo？[J]. Otolaryngol Head Neck Surg, 2006, 134(3): 451-454.
13
Imai T, Ito M, Takeda N, et al.Natural course of the remission ofvertigo in patients with benign paroxysmal positional vertigo[J]. Neurology, 2005, 64(5): 920-921.
14
熊彬彬，吴子明，刘兴建，等. 良性阵发性位置性眩晕的临床特征分析[J]. 中华耳科学杂志，2012，10(2): 208-211.
15
Pavlou M, Lingeswaran A, Davies RA, et al.Simulator based rehabilitation in refractory dizziness[J]. J Neurol, 2004, 251(8): 983-995.
16
朱祖福，徐静泓，张慧萍，等. Brandt-Daroff习服训练联合手法复位治疗良性阵发性位置性眩晕疗效观察[J]. 海南医学，2016，27(2): 297-298.
17
Guneri EA, Kustutan O.The effects of betahlistine in addition to epleymaneuver in posterior canal benign paroxysmal positional vertigo[J]. Otolaryngol Head Neck Surg, 2012, 146(1): 104-108.
18
丁晓云，古辉，罗建平，等. 倍他司汀治疗眩晕80例疗效观察[J]. 现代诊断与治疗，2013，24(15): 3433-3434.
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