| [1] |
De Bree A，Verschuren WM，Kromhout D，et al.Homocysteine determinants and the evidence to what extent homocysteine determines the risk of coronary heart disease[J]．Pharmacol Rev，2002，54(4)：599-618.
|
| [2] |
Zhou J，Austin RC.Contributions of hyperhomocysteinemia to atherosclerosis: Causal relationship and potential mechanisms[J]．Biofactors，2009，35(2)：120-129.
|
| [3] |
Singh Y，Samuel VP，Dahiya S，et al.Combinational effect of angiotensin receptor blocker and folic acid therapy on uric acid and creatinine level in hyperhomocysteinemia-associated hypertension[J]．Biotechnol Appl Biochem，2019，66(5)：715-719.
|
| [4] |
McCully KS.Vascular pathology of homocysteinemia：implications for the pathogenesis of arteriosclerosis[J]．Am J Pathol，1969，56(1)：111-128.
|
| [5] |
Zhou Z，Liang Y，Qu H，et al.Plasma homocysteine concentrations and risk of intracerebral hemorrhage: a systematic review and meta-analysis[J]．Sci Rep，2018，8(1)：2568.
|
| [6] |
Esse R，Barroso M，Tavares de Almeida I，et al.The Contribution of Homocysteine Metabolism Disruption to Endothelial Dysfunction: State-of-the-Art[J]．Int J Mol Sci，2019，20(4)：530-533.
|
| [7] |
张英，崇丽宁，李继梅．脑出血与同型半胱氨酸的临床相关性分析[J]．中国卒中杂志，2017，12(8)：691-695.
|
| [8] |
Li Z，Sun L，Zhang H，et al.Elevated plasma homocysteine was associated with hemorrhagic and ischemic stroke，but methylenetetrahydrofolate reductase gene C677T polymorphism was a risk factor for thrombotic stroke：a multicenter case-control study in China[J]．Stroke，2003，34(9)：2085-2090.
|
| [9] |
Zhou Z，Liang Y，Qu H，et al.Plasma homocysteine concentrations and risk of intracerebral hemorrhage: a systematic review and meta-analysis[J]．Sci Rep，2018，8(1)：2568.
|
| [10] |
Zhou F，Chen B，Chen C，et al.Elevated homocysteine levels contribute to larger hematoma volume in patients with intracerebral hemorrhage[J]．J Stroke Cerebrovasc Dis，2015，24(4)：784-788.
|
| [11] |
Ribo M，Montaner J，Monasterio J，et al.Role of homocysteine in the acute phase of stroke[J]．Neurologia，2004，19(1)：10-14.
|
| [12] |
胡大一，徐希平．有效控制"H型"高血压——预防卒中的新思路[J]．中华内科杂志，2008，47(12)：976-977.
|
| [13] |
Graham ILE，Daly LE，Refsum HM，et al.Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project[J]．JAMA，1997，277(22)：1775-1781.
|
| [14] |
秦青通，张丹红．血浆同型半胱氨酸与原发性高血压及脑出血的关系[J]．中国危重病急救医学，2003，15(9)：518-518.
|
| [15] |
Abidi O，Haissam M，Nahili H，et al.Methylenetetrahydrofolate reductase gene polymorphisms(C677T and A1298C) and hemorrhagic stroke in moroccan patients[J]．J Stroke Cerebrovasc Dis，2018，27(7)：1837-1843.
|
| [16] |
Lominadze D，Roberts AM，Tyagi N，et al.Homocysteine causes cerebrovascular leakage in mice[J]．Am J Physiol Heart Circ Physiol，2006，290(3)：1206-1213.
|
| [17] |
Brinckerhoff CE，Matrisian LM.Matrix metalloproteinases：a tail of a frog that became a prince[J]．Nat Rev Mol Cell Biol，2002，3(3)：207-214.
|
| [18] |
Koh SH，Park CY，Kim MK，et al.Microbleeds and free active MMP-9 are independent risk factors for neurological deterioration in acute lacunar stroke[J]．Eur J Neurol，2011，18(1)：158-164.
|
| [19] |
Lei C，Lin S，Zhang C，et al.Activation of cerebral recovery by matrix metalloproteinase-9 after intracerebral hemorrhage[J]．Neuroscience，2013，230(11)：86-93.
|
| [20] |
Gao D，Ding F，Lei G，et al.Effects of focal mild hypothermia on thrombin-induced brain edema formation and the expression of protease activated receptor-1，matrix metalloproteinase-9 and aquaporin 4 in rats[J]．Mol Med Rep，2015，11(4)：3009-3014.
|
| [21] |
Tyagi N，Gillespie WJC，Vacek JC，et al.Activation of GABA-A receptor ameliorates homocysteine-induced MMP-9 activation by ERK pathway[J]．J Cell Physiol，2009，220(1)：257-266.
|
| [22] |
Min H，Hong J，Cho IH，et al.TLR2-induced astrocyte MMP9 activation compromises the blood brain barrier and exacerbates intracerebral hemorrhage in animal models[J]．Mol Brain，2015，8(3)：23-26.
|
| [23] |
Xu Y，Tian Y，Wei HJ，et al.Methionine diet-induced hyperhomocysteinemia accelerates cerebral aneurysm formation in rats[J]．Neurosci Lett，2011，494(2)：139-144.
|
| [24] |
Korai M，Kitazato KT，Tada Y，et al.Hyperhomocysteinemia induced by excessive methionine intake promotes rupture of cerebral aneurysms in ovariectomized rats[J]．J Neuroinflammation，2016，13(1)：165.
|
| [25] |
Ren JR，Ren SH，Ning B，et al.Hyperhomocysteinemia as a risk factor for saccular intracranial aneurysm：a cohort study in a chinese han population[J]．J Stroke Cerebrovasc Dis，2017，26(12)：2720-2726.
|
| [26] |
Rosi J，Morais BA，Pecorino LS，et al.Hyperhomocysteinemia as a risk factor for intracranial aneurysms：a case-control study[J]．World Neurosurg，2018，119(17)：e272-e275.
|
| [27] |
Chen SJ，Tsai HH，Tsai LK，et al.Advances in cerebral amyloid angiopathy imaging[J]．Ther Adv Neurol Disord，2019，12(1)：113-117.
|
| [28] |
Hineno A，Ikeda S．Cerebral amyloid angiopathy[J]．Nihon Rinsho，2011，11(5)：140-147.
|
| [29] |
Lee SS，Stemmermann GN.Congophilic angiopathy and cerebral hemorrhage[J]．Arch Pathol Lab Med，1978，102(6)：317-321.
|
| [30] |
Sakai K，Ueda M，Fukushima W，et al.Nationwide survey on cerebral amyloid angiopathy in Japan[J]．Eur J Neurol，2019，26(12)：1487-1493.
|
| [31] |
Li JG，Praticò D．High levels of homocysteine results in cerebral amyloid angiopathy in mice[J]．J Alzheimers Dis，2015，43(1)：29-35.
|
| [32] |
吴志武．急性缺血性脑卒中静脉溶栓后早期改善脑血循环治疗研究进展[J]．中国医学创新，2019，16(18)：164-167.
|
| [33] |
Powers WJ，Rabinstein AA，Ackerson T，et al. Guidelines for the early management of patients with acute ischemic stroke：2019 update to the 2018 guidelines for the early management of acute ischemic stroke：a guideline for healthcare professionals from the american heart association/american stroke association[J]．Stroke，2019，50(12)：344-418.
|
| [34] |
Asahi M，Wang X，Mori T，et al.Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia[J]．J Neurosci，2001，21(19)：7724-7732.
|
| [35] |
Fujimura M，Gasche Y，Morita-Fujimura Y，et al.Early appearance of activated matrix metalloproteinase-9 and blood-brain barrier disruption in mice after focal cerebral ischemia and reperfusion[J]．Brain Res，1999，842(1)：92-100.
|
| [36] |
Rosenberg GA，Cunningham LA，Wallace J，et al.Immunohistochemistry of matrix metalloproteinases in reperfusion injury to rat brain：activation of MMP-9 linked to stromelysin-1 and microglia in cell cultures[J]．Brain Res，2001，893(15)：104-112.
|
| [37] |
Sumii T，Lo EH.Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in rats[J]．Stroke，2002，33(3)：831-836.
|
| [38] |
Yao ES，Tang Y，Xie MJ，et al.Elevated homocysteine level related to poor outcome after thrombolysis in acute ischemic stroke[J]．Med Sci Monit，2016，22(17)：3268-3273.
|
| [39] |
Ling-Cong，Hong-Zhao，Yu-Wang，et al.The serum homocysteine level in patients with acute ischemic stroke (AIS) after thrombolysis and its relationship with clinical outcomes[J]．Rev Assoc Med Bras (1992)，2018，64(5)：438-442.
|
| [40] |
Ribo M，Montaner J，Molina CA，et al.Admission fibrinolytic profile is associated with symptomatic hemorrhagic transformation in stroke patients treated with tissue plasminogen activator[J]．Stroke，2004，35(9)：2123-2127.
|
| [41] |
Caunca MR，Del Brutto V，Gardener H，et al.Cerebral microbleeds，vascular risk factors，and magnetic resonance imaging markers：northern manhattan study[J]．J Am Heart Assoc，2016，5(9)：179-186.
|
| [42] |
Ovbiagele B，Liebeskind DS，Pineda S，et al.Strong independent correlation of proteinuria with cerebral microbleeds in patients with stroke and transient ischemic attack[J]．Arch Neurol，2010，67(1)：45-50.
|
| [43] |
Wang BR，Ou Z，Jiang T，et，al.Independent correlation of serum homocysteine with cerebral microbleeds in patients with acute ischemic stroke due to large-artery atherosclerosis[J]．J Stroke Cerebrovasc Dis，2016，25(11)：2746-2751.
|
| [44] |
Nam KW，Kwon HM，Jeong HY，et al.Serum homocysteine level is related to cerebral small vesseldisease in a healthy population[J]. Neurology，2019，92(4)：317-325.
|