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中华卫生应急电子杂志 ›› 2020, Vol. 06 ›› Issue (06) : 356 -359. doi: 10.3877/cma.j.issn.2095-9133.2020.06.007

所属专题: 文献

论著

重症和不同分期ITP患者外周血淋巴细胞计数及其与生化指标的相关性
范江砂1, 徐文艳2,()   
  1. 1. 213017 江苏常州,江苏大学附属武进医院血液科、徐州医科大学武进临床学院
    2. 213017 江苏常州,江苏大学附属武进医院输血科、徐州医科大学武进临床学院
  • 收稿日期:2020-10-09 出版日期:2020-12-18
  • 通信作者: 徐文艳

Difference of peripheral blood lymphocyte count and its correlation with biochemical indexes in severe immune thrombocytopenia with different stages

Jiangsha Fan1, Wenyan Xu2,()   

  1. 1. Department of Hematology, Wujin Hospital Affiliated with Jiangsu University, The Wujin Clinical college of Xuzhou Medical University, Changzhou 213017, China
    2. Department of Blood Transfusion, Wujin Hospital Affiliated with Jiangsu University, The Wujin Clinical college of Xuzhou Medical University, Changzhou 213017, China
  • Received:2020-10-09 Published:2020-12-18
  • Corresponding author: Wenyan Xu
  • About author:
    Corresponding author: Xu Wenyan, Email:
引用本文:

范江砂, 徐文艳. 重症和不同分期ITP患者外周血淋巴细胞计数及其与生化指标的相关性[J/OL]. 中华卫生应急电子杂志, 2020, 06(06): 356-359.

Jiangsha Fan, Wenyan Xu. Difference of peripheral blood lymphocyte count and its correlation with biochemical indexes in severe immune thrombocytopenia with different stages[J/OL]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2020, 06(06): 356-359.

目的

比较重症与非重症原发免疫性血小板减少症(ITP)患者及不同分期的ITP患者、合并其他自身免疫病的ITP患者外周血淋巴细胞计数、中性粒细胞/淋巴细胞比率(NLR)、血小板/淋巴细胞比率(PLR)的差异以及与生化指标的相关性分析。

方法

无菌采集47例ITP患者其中重症12例抗凝及促凝外周静脉血各2mL,检测中性粒细胞、淋巴细胞及血小板计数,计算NLR和PLR,并检测乳酸脱氢酶、白蛋白、球蛋白、胆固醇、甘油三酯,低密度脂蛋白、C反应蛋白指标。

结果

重症ITP患者外周血中性粒细胞计数低于非重症ITP患者[(4.43±2.09)×109/L比(6.91±3.63)×109/L,P<0.05];新诊断ITP、持续性ITP,慢性ITP、合并其他自身免疫性疾病的ITP四组患者的淋巴细胞计数差异有统计学意义(χ2=9.22,P<0.05);ITP患者外周血淋巴细胞计数与白蛋白呈负相关(r=-0.728,P<0.05),PLR与乳酸脱氢酶呈负相关(r=-0.415,P<0.05)。

结论

重症和不同分期ITP患者外周血淋巴细胞计数、中性粒细胞计数可能是其预后判断的指标之一。

Objective

To investigate the differences of peripheral blood lymphocyte count, NLR, PLR and their correlation with biochemical indexes in severe immune thrombocytopenia (ITP) and different stages of ITP.

Methods

A total of 47 ITP patients was enrolled in this study, including 12 severe cases. Each 2 ml of anticoagulant and procoagulant peripheral venous blood was collected, neutrophils, lymphocytes and platelets, and LDH, Alb, Glb, TC, TG, LDL-C, CRP were detected, and NLR and PLR were calculated.

Results

Neutrophil count in peripheral blood of patients with severe ITP was lower than that of non-severe ITP patients [(4.43±2.09)×109/L vs. (6.91±3.63)×109/L, P<0.05]; there were significant differences in lymphocyte count among the four groups of patients with newly diagnosed ITP, persistent ITP, chronic ITP and ITP patients with other autoimmune diseases(χ2=9.22, P<0.05). Peripheral blood lymphocyte count was negatively correlated with albumin(r=-0.728, P<0.05) and PLR was negatively correlated with LDH in ITP patients(r=-0.415, P<0.05).

Conclusion

Peripheral blood lymphocyte count and neutrophil count may be one of the prognostic indicators of severe ITP patients and their different stages.

表1 两组ITP淋巴细胞计数、中性粒细胞计数、NLR、PLR比较(±s)
表2 四组ITP淋巴细胞计数、NLR、PLR比较(±s)
表3 ITP患者外周血淋巴细胞计数、NLR、PLR与临床指标的相关性分析
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