1 | Gao Q,Hernandes MS.Sepsis-associated encephalopathy and blood-brain barrier dysfunction[J].Inflammation,2021,44(6):2143-2150. |
2 | Dumbuya JS,Li S,Liang L,et al.Paediatric sepsis-associated encephalopathy (SAE):a comprehensive review[J].Mol Med,2023,29(1):27. |
3 | Mazeraud A,Righy C,Bouchereau E,et al.Septic-associated encephalopathy:a comprehensive review[J].Neurotherapeutics,2020,17(2):392-403. |
4 | Hatch R,Young D,Barber V,et al.Anxiety,depression and post traumatic stress disorder after critical illness:a UK-wide prospective cohort study[J].Crit Care,2018,22(1):310. |
5 | Righy C,Rosa RG,da Silva RTA,et al.Prevalence of post-traumatic stress disorder symptoms in adult critical care survivors:a systematic review and meta-analysis[J].Crit Care,2019,23(1):213. |
6 | Heming N,Mazeraud A,Verdonk F,et al.Neuroanatomy of sepsis-associated encephalopathy[J].Crit Care,2017,21(1):65. |
7 | Haileselassie B,Joshi AU,Minhas PS,et al.Mitochondrial dysfunction mediated through dynamin-related protein 1(Drp1) propagates impairment in blood brain barrier in septic encephalopathy[J].J Neuroinflammation,2020,17(1):36. |
8 | Xin Y,Tian M,Deng S,et al.The key drivers of brain injury by systemic inflammatory responses after sepsis:microglia and neuroinflammation[J].Mol Neurobiol,2023,60(3):1369-1390. |
9 | Yan X,Yang K,Xiao Q,et al.Central role of microglia in sepsis-associated encephalopathy:From mechanism to therapy[J].Front Immunol,2022(13):929316. |
10 | Pan S,Lv Z,Wang R,et al.Sepsis-induced brain dysfunction:pathogenesis, diagnosis,and treatment[J].Oxid Med Cell Longev,2022(2022):1328729. |
11 | Zhao P,Li X,Yang Q,et al.Malvidin alleviates mitochondrial dysfunction and ROS accumulation through activating AMPK-α/UCP2 axis,thereby resisting inflammation and apoptosis in SAE mice[J].Front Pharmacol,2022(13):1038802. |
12 | Sharshar T,Gray F,Lorin de la Grandmaison G,et al.Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock[J].Lancet,2003,362(9398):1799-1805. |
13 | Azabou E,Navarro V,Kubis N,et al.Value and mechanisms of EEG reactivity in the prognosis of patients with impaired consciousness:a systematic review[J].Crit Care,2018,22(1):184. |
14 | Tovote P,Fadok JP,Lüthi A.Neuronal circuits for fear and anxiety[J].Nat Rev Neurosci,2015,16(6):317-331. |
15 | Polito A,Eischwald F,Maho AL,et al.Pattern of brain injury in the acute setting of human septic shock[J].Crit Care,2013,17(5):R204. |
16 | Mayer EA,Nance K,Chen S.The gut-brain axis[J].Annu Rev Med,2022(73):439-453. |
17 | Margolis KG,Cryan JF,Mayer EA.The microbiota-gut-brain axis:from motility to mood[J].Gastroenterology,2021,160(5):1486-1501. |
18 | Sun T,Wang L,Zhang H.Intestinal microbiota in sepsis[J].Intensive Care Research,2022,2(1):1-7. |
19 | Erny D,Hrabě de Angelis AL,Jaitin D,et al.Host microbiota constantly control maturation and function of microglia in the CNS[J].Nat Neurosci,2015,18(7):965-977. |
20 | Fang H,Wang Y,Deng J,et al.Sepsis-Induced gut dysbiosis mediates the susceptibility to sepsis-associated encephalopathy in mice[J].mSystems,2022,7(3):e0139921. |
21 | Singer BH,Dickson RP,Denstaedt SJ,et al.Bacterial dissemination to the brain in sepsis[J].Am J Respir Crit Care Med,2018,197(6):747-756. |
22 | Wolf SA,Boddeke HW,Kettenmann H.Microglia in physiology and disease[J].Annu Rev Physiol,2017(79):619-643. |
23 | Zrzavy T,H?ftberger R,Berger T,et al.Pro-inflammatory activation of microglia in the brain of patients with sepsis[J].Neuropathol Appl Neurobiol,2019,45(3): 278-290. |
24 | Kodali MC,Chen H,Liao FF.Temporal unsnarling of brain’s acute neuroinflammatory transcriptional profiles reveals panendothelitis as the earliest event preceding microgliosis[J].Mol Psychiatry,2021,26(8):3905-3919. |
25 | Brown LS,Foster CG,Courtney JM,et al.Pericytes and neurovascular function in the healthy and diseased brain[J].Front Cell Neurosci,2019(13):282. |
26 | Rosengarten B,Krekel D,Kuhnert S,et al.Early neurovascular uncoupling in the brain during community acquired pneumonia[J].Crit Care,2012,16(2):R64. |
27 | Taccone FS,Su F,Pierrakos C,et al.Cerebral microcirculation is impaired during sepsis:an experimental study[J].Crit Care,2010,14(4):R140. |
28 | Hosokawa K,Gaspard N,Su F,et al.Clinical neurophysiological assessment of sepsis-associated brain dysfunction:a systematic review[J].Crit Care,2014,18 (6):674. |
29 | Barichello T,Generoso JS,Singer M,et al.Biomarkers for sepsis:more than just fever and leukocytosis-a narrative review[J].Crit Care,2022,26(1):14. |
30 | Oddo M,Carrera E,Claassen J,et al.Continuous electroencephalography in the medical intensive care unit[J].Crit Care Med,2009,37(6):2051-2056. |
31 | Nielsen RM,Urdanibia-Centelles O,Vedel-Larsen E,et al.Continuous EEG monitoring in a consecutive patient cohort with sepsis and delirium[J].Neurocrit Care,2020,32(1):121-130. |
32 | Gilmore EJ,Gaspard N,Choi HA,et al.Acute brain failure in severe sepsis: a prospective study in the medical intensive care unit utilizing continuous EEG monitoring[J].Intensive Care Med,2015,41(4):686-694. |
33 | Azabou E,Magalhaes E,Braconnier A,et al.Early standard electroencephalogram abnormalities predict mortality in septic intensive care unit patients[J].PLoS One,2015,10(10):e0139969. |
34 | Azabou E,Rohaut B,Heming N,et al.Early impairment of intracranial conduction time predicts mortality in deeply sedated critically ill patients:a prospective observational pilot study[J].Ann Intensive Care,2017,7(1):63. |
35 | Stubbs DJ,Yamamoto AK,Menon DK.Imaging in sepsis-associated encephalopathy--insights and opportunities[J].Nat Rev Neurol,2013,9(10):551-561. |
36 | 艾美林,黄立,冯清,等.经颅多普勒超声在早期诊断脓毒症相关性脑病中的临床意义[J].中华内科杂志,2019,58(11):814-818. |
37 | Yang Z,Qin C,Zhang S,et al.Bedside ultrasound measurement of optic nerve sheath diameter in patients with sepsis:a prospective observational study[J].Crit Care,2020,24(1):235. |
38 | Tang CX,Zhou WS,Chen XY,et al.Research progress of biomarkers of sepsis-associated encephalopathy[J].Intensive Care Research, 2023, 3 (1): 69-76. |
39 | Di Pietro V,Yakoub KM,Scarpa U,et al. MicroRNA signature of traumatic brain injury:from the biomarker discovery to the point-of-care[J].Front Neurol,2018(9):429. |
40 | Beltrán-García J,Osca-Verdegal R,Romá-Mateo C,et al.Epigenetic biomarkers for human sepsis and septic shock:insights from immunosuppression[J].Epigenomics,2020,12(7):617-646. |
41 | Osca-Verdegal R,Beltrán-García J,Pallardó FV,et al.Role of microRNAs as biomarkers in sepsis-associated encephalopathy[J].Mol Neurobiol,2021,58(9):4682-4693. |
42 | Wei XB,Jiang WQ,Zeng JH,et al.Exosome-derived lncRNA NEAT1 exacerbates sepsis-associated encephalopathy by promoting ferroptosis through regulating miR-9-5p/TFRC and GOT1 axis[J].Mol Neurobiol,2022,59(3):1954-1969. |
43 | Zou L,He J,Gu L,et al.Brain innate immune response via miRNA-TLR7 sensing in polymicrobial sepsis[J].Brain Behav Immun,2022(100):10-24. |
44 | Wu Y,Li P,Liu L,et al.lncRNA Neat1 regulates neuronal dysfunction post-sepsis via stabilization of hemoglobin subunit beta[J].Mol Ther,2022,30(7):2618-2632. |
45 | Needham DM,Colantuoni E,Dinglas VD,et al.Rosuvastatin versus placebo for delirium in intensive care and subsequent cognitive impairment in patients with sepsis-associated acute respiratory distress syndrome:an ancillary study to a randomised controlled trial[J].Lancet Respir Med,2016,4(3):203-212. |
46 | Shehabi Y,Howe BD,Bellomo R,et al.Early sedation with dexmedetomidine in critically ill patients[J].N Engl J Med,2019,380(26):2506-2517. |
47 | van Eijk MM,Roes KC,Honing ML,et al.Effect of rivastigmine as an adjunct to usual care with haloperidol on duration of delirium and mortality in critically ill patients: a multicentre, double-blind, placebo-controlled randomised trial[J]. Lancet,2010,376(9755):1829-1837. |