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中华卫生应急电子杂志 ›› 2023, Vol. 09 ›› Issue (05) : 257 -262. doi: 10.3877/cma.j.issn.2095-9133.2023.05.001

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创伤性内皮病发生机制、临床评估及治疗研究进展
朱志豪1, 刘晓彬2, 朱峰3,()   
  1. 1. 330006 江西南昌,南昌大学第一附属医院烧伤整形与创面修复医学中心
    2. 200120 上海,同济大学附属东方医院重症医学科
    3. 200433 上海,海军军医大学第一附属医院烧伤科
  • 收稿日期:2023-09-30 出版日期:2023-10-18
  • 通信作者: 朱峰
  • 基金资助:
    国家重点研发计划"干细胞及转化研究"重点专项(2019YFA0110601)

Research progress in the pathogenesis, clinical evaluation, and treatment of traumatic endothelial disease

Zhihao Zhu, Xiaobin Liu, Feng Zhu()   

  • Received:2023-09-30 Published:2023-10-18
  • Corresponding author: Feng Zhu
引用本文:

朱志豪, 刘晓彬, 朱峰. 创伤性内皮病发生机制、临床评估及治疗研究进展[J]. 中华卫生应急电子杂志, 2023, 09(05): 257-262.

Zhihao Zhu, Xiaobin Liu, Feng Zhu. Research progress in the pathogenesis, clinical evaluation, and treatment of traumatic endothelial disease[J]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2023, 09(05): 257-262.

严重创伤是全球范围内导致人群死亡的主要原因,尤其是在中青年人群中[1]。创伤后机体在出血、组织损伤及抗凝和纤溶激活等多因素调控下,会诱发早期急性凝血病[2]。内皮细胞(endothelial cells,ECs)表面覆盖的带有负电荷的内皮糖萼(endothelialglycocalyx,EG)及其内蕴含的乙酰肝素侧链可以与抗凝血酶相互作用,在内皮未受损情况下发挥抗凝作用[3]。不仅如此,ECs作为受损器官和效应器在冠心病、脓毒症及肺动脉高压等多类疾病中发挥重要作用[4,5,6]。创伤及失血后ECs受损可致血管ECs脱落[7],血液内会出现如Sydecan-1(SDC1)、透明质酸及硫酸软骨素等EG损伤标志物,此类损伤标志物的增加与患者创伤后血液低凝状态息息相关[8]。在创伤介导的EG脱落和损伤会进一步诱发内皮细胞的激活,加重全身低凝状态,内皮正常功能丧失,最终导致功能障碍,这一类的损伤变化被称为创伤性内皮病(endotheliopathy of trauma,EoT)[9]

1
GBD 2019 Diseases and Injuries Collaborators.Global burden of 369 diseases and injuries in 204 countries and territories,1990-2019: a systematic analysis for the global burden of disease study 2019 [J]. Lancet2020396(10258):1204-1222.
2
Kornblith LZMoore HBCohen MJ.Trauma-induced coagulopathy:The past,present,and future[J].J Thromb Haemost201917(6):852-862.
3
Sheppard FRSchaub LJCap AP,et al.Whole blood mitigates the acute coagulopathy of trauma and avoids the coagulopathy of crystalloid resuscitation[J].J Trauma Acute Care Surg201885(6):1055-1062
4
Pierce RWShabanova VCanarie M,et al.Angiopoietin level trajectories in toddlers with severe sepsis and septic shock and their effect on capillary endothelium[J].Shock201951(3):298-305.
5
Borges JPNascimento ARLopes GO,et al.The impact of exercise frequency upon microvascular endothelium function and oxidative stress among patients with coronary artery disease[J].Clin Physiol Funct Imaging201838(5):840-846.
6
Harel FLangleben DProvencher S,et al.Molecular imaging of the human pulmonary vascular endothelium in pulmonary hypertension:a phase II safety and proof of principle trial[J].Eur J Nucl Med Mol Imaging201744(7):1136-44.
7
杨映波,王正国,朱佩芳,等. 创伤病人循环内皮细胞体外培养的研究[J]. 中华创伤杂志19939(6):317-319.
8
Hahn RGPatel VDull RO.Human glycocalyx shedding:systematic review and critical appraisal[J].Acta Anaesthesiol Scand202165(5):590-606.
9
尹文,冯筑生. 系统性内皮病在创伤性休克领域研究[J]. 创伤外科杂志202123(11):801-804.
10
Cardenas JCDong JFKozar RA.Injury-induced endotheliopathy:what you need to know [J].J Trauma Acute Care Surg202395(4):454-463.
11
Patterson EKCepinskas GFraser DD.Endothelial glycocalyx degradation in critical illness and injury[J].Front Med(Lausanne)2022(9):898592.
12
Moore KHMurphy HAGeorge EM. The glycocalyx: a central regulator of vascular function[J].Am J Physiol Regul Integr Comp Physiol2021320(4):R508-R518.
13
Wang GKostidis STiemeier GL,et al. Shear stress regulation of endothelial glycocalyx structure is determined by glucobiosynthesis[J].Arterioscler Thromb Vasc Biol202040(2):350-364.
14
Gonzalez Rodriguez EOstrowski SRCardenas JC,et al.Syndecan-1:a quantitative marker for the endotheliopathy of trauma[J].J Am Coll Surg2017225(3):419-427.
15
Plug TMeijers JC.Structure-function relationships in thrombin-activatable fibrinolysis inhibitor[J].J Thromb Haemost201614(4):633-644.
16
Bouma BNMarx PFMosnier LO,et al.Thrombin-activatable fibrinolysis inhibitor(TAFI,plasma procarboxypeptidase b,procarboxypeptidase r,procarboxypeptidase u)[J].Thromb Res2001101(5):329-354.
17
Brohi KCohen MJGanter MT,et al.Acute traumatic coagulopathy:initiated by hypoperfusion:modulated through the protein c pathway?[J].Ann Surg2007245(5):812-818.
18
Knipe LMeli AHewlett L,et al.A revised model for the secretion of tPA and cytokines from cultured endothelial cells[J].Blood2010116(12):2183-2191.
19
Hayakawa MTsuchida THonma Y,et al.Fibrinolytic system activation immediately following trauma was quickly and intensely suppressed in a rat model of severe blunt trauma[J].Sci Rep202111(1):20283.
20
Chapman MPMoore EEMoore HB,et al.Overwhelming tPA release,not PAI-1 degradation,is responsible for hyperfibrinolysis in severely injured trauma patients[J].J Trauma Acute Care Surg201680(1):16-23.
21
Gall LSVulliamy PGillespie S,et al.The S100A10 pathway mediates an occult hyperfibrinolytic subtype in trauma patients[J].Ann Surg2019269(6):1184-1191.
22
Sang YRoest Mde Laat B,et al.Interplay between platelets and coagulation[J].Blood Rev2021(46):100733.
23
Neubauer KZieger B.Endothelial cells and coagulation[J].Cell Tissue Res2022387(3):391-398.
24
Gkaliagkousi ERitter JFerro A.Platelet-derived nitric oxide signaling and regulation[J].Circ Res2007101(7):654-662.
25
Johansson PIStensballe JOstrowski SR.Shock induced endotheliopathy(SHINE)in acute critical illness-a unifying pathophysiologic mechanism[J].Crit Care201721(1):25.
26
Johansson PIEriksen CFSchmal H,et al.Efficacy and safety of iloprost in trauma patients with haemorrhagic shock-induced endotheliopathy-Protocol for the multicentre randomized,placebo-controlled,blinded,investigator-initiated shine-trauma trial[J].Acta Anaesthesiol Scand202165(4):551-557.
27
Henriksen HHMarín de Mas INielsen LK,et al.Endothelial cell phenotypes demonstrate different metabolic patterns and predict mortality in trauma patients[J].Int J Mol Sci202324(3):2257.
28
Johansson PIHenriksen HHStensballe J,et al.Traumatic endotheliopathy:a prospective observational study of 424 severely injured patients[J].Annals of surgery2017265(3):597-603.
29
Chesebro BBRahn PCarles M,et al.Increase in activated protein C mediates acute traumatic coagulopathy in mice[J].Shock200932(6):659-665.
30
Wallen TESinger KEElson NC,et al.Defining endotheliopathy in murine polytrauma models[J].Shock202257(6):291-298.
31
Barrett LCurry NAbu-Hanna J.Experimental models of traumatic injuries:do they capture the coagulopathy and underlying endotheliopathy induced by human trauma?[J].Int J Mol Sci202324(13):11174.
32
Bunch CMChang EMoore EE,et al.SHock-INduced Endotheliopathy(SHINE):a mechanistic justification for viscoelastography-guided resuscitation of traumatic and non-traumatic shock[J].Front Physiol2023(14):1094845.
33
Yang ZLe TDSimovic MO,et al.Traumatized triad of complementopathy,endotheliopathy,and coagulopathy-Impact on clinical outcomes in severe polytrauma patients[J].Front Immunol2022(13):991048.
34
Keyloun JWLe TDOrfeo T,et al.Assessing factor v antigen and degradation products in burn and trauma patients[J].J Surg Res2022(274):169-177.
35
Johansson PIStensballe JRasmussen LS,et al.High circulating adrenaline levels at admission predict increased mortality after trauma[J].J Trauma Acute Care Surg201272(2):428-436.
36
Ostrowski SRJohansson PI.Endothelial glycocalyx degradation induces endogenous heparinization in patients with severe injury and early traumatic coagulopathy [J].J Trauma Acute Care Surg201273(1):60-66.
37
Johansen MEJohansson PIOstrowski SR,et al.Profound endothelial damage predicts impending organ failure and death in sepsis[J].Semin Thromb Hemost201541(1):16-25.
38
Johansson PISørensen AMPerner A,et al.Elderly trauma patients have high circulating noradrenaline levels but attenuated release of adrenaline,platelets,and leukocytes in response to increasing injury severity[J].Crit Care Med201240(6):1844-1850.
39
Fröhlich MLefering RProbst C,et al.Epidemiology and risk factors of multiple-organ failure after multiple trauma:an analysis of 31,154 patients from the TraumaRegister DGU[J].J Trauma Acute Care Surg201476(4):921-927.
40
Krocker JDLee KHHenriksen HH,et al.Exploratory investigation of theplasma proteome associated with the endotheliopathy of trauma[J].Int J Mol Sci202223(11):6213.
41
Wang SSong RWang Z,et al.S100A8/A9 in inflammation[J].Front Immunol2018(9):1298.
42
Staedtke VBai RYKim K,et al.Disruption of a self-amplifying catecholamine loop reduces cytokine release syndrome[J].Nature2018564(7735):273-277.
43
Thul PJÅkesson LWiking M,et al.A subcellular map of the human proteome[J].Science2017356(6340):eaal3321.
44
Erukhimov JATang ZLJohnson BA,et al.Actin-containing sera from patients with adult respiratory distress syndrome are toxic to sheep pulmonary endothelial cells[J].Am J Respir Crit Care Med2000162(1):288-294.
45
Haywood-Watson RJHolcomb JBGonzalez EA,et al.Modulation of syndecan-1 shedding after hemorrhagic shock and resuscitation[J].PloS one20116(8):e23530.
46
Johansson PIStensballe JOliveri R,et al.How i treat patients with massive hemorrhage[J].Blood2014124(20):3052-3058.
47
Lopez EPeng ZKozar RA,et al.Antithrombin III contributes to the protective effects of fresh frozen plasma following hemorrhagic shock by preventing syndecan-1 shedding and endothelial barrier disruption[J].Shock202053(2):156-163.
48
Deng XCao YHuby MP,et al.Adiponectin in fresh frozen plasma contributes to restoration of vascular barrier function after hemorrhagic shock[J].Shock201645(1):50-54.
49
Bruggeman LAPellicoro JAHorigan EA,et al.Thromboxane and prostacyclin differentially regulate murine extracellular matrix gene expression[J].Kidney Int199343(6):1219-1225.
50
Sussmann MSarbia MMeyer-Kirchrath J,et al.Induction of hyaluronic acid synthase 2(HAS2)in human vascular smooth muscle cells by vasodilatory prostaglandins[J].Circ Res200494(5):592-600.
51
Kawabe JYuhki KOkada M,et al.Prostaglandin I2 promotes recruitment of endothelial progenitor cells and limits vascular remodeling[J].Arterioscler Thromb Vasc Biol201030(3):464-470.
52
Birukova AATian YDubrovskyi O,et al.VE-cadherin trans-interactions modulate Rac activation and enhancement of lung endothelial barrier by iloprost[J].J Cell Physiol2012227(10):3405-3416.
53
Joffre JHellman JInce C,et al.Endothelial responses in sepsis[J].Am J Respir Crit Care Med2020202(3):361-370.
54
Gao WFang FXia TJ,et al.Doxycycline can reduce glycocalyx shedding by inhibiting matrix metalloproteinases in patients undergoing cardiopulmonary bypass: a randomized controlled trial[J].Microvasc Res2022(142):104381.
55
Vidaurre MOsborn BKLowak KD,et al.A 3-O-sulfated heparan sulfate dodecasaccharide(12-mer)suppresses thromboinflammation and attenuates early organ injury following trauma and hemorrhagic shock[J].Front Immunol2023(14):1158457.
56
Anderson TNHinson HEDewey EN,et al.Early tranexamic acid administration after traumatic brain injury is associated with reduced syndecan-1 and angiopoietin-2 in patients with traumatic intracranial hemorrhage[J].J Head Trauma Rehabil202035(5):317-323.
57
Thielen OMitra SDebot M,et al.Mitigation of trauma induced endotheliopathy by activated protein c: a potential therapeutic for post-injury thromboinflammation[EB/OL].(2023-09-21)[2023-09-30].

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