探讨严重创伤后凝血病的早期诊断与新疗法治疗的疗效。

选取我院2007年1月至2014年12月收治的严重创伤合并凝血病患者64例，外院紧急会诊救治患者9例作为研究对象。分为对照组和治疗组，对照组采用相关综合治疗，治疗组在综合治疗基础上，采用20AA高支链肝病复方氨基酸注射液(丰诺安)联用大剂量维生素B₆新疗法。观察患者15 d死亡率的变化。

与对照组比较，治疗组死亡率得到显著降低，大出血一般在1.5～72 h逐步得到控制，最快的1例在静脉输入1 h就明显控制了大出血，肝功能都有明显好转。

在综合治疗基础上采用20AA高支链肝病复方氨基酸注射液(丰诺安)联用大剂量B₆新疗法对救治严重创伤后凝血病患者效果明显。

To explore novel therapy for patients with coagulopathy after severe trauma.

A total of 73 patients with traumatic coagulopathy from Affiliated Wujin Hospital of Jiangsu University and other hospitals were enrolled in the study and randomly divided into control group (n=32) and therapy group (n=41). The patients in control group received comprehensive treatment while the those in therapy group received combined use of compound amino acids and large doses of vitamin B₆. The mortality rate during 15 days were analyzed.

Compared with control group, the mortality rate in the therapy group was significantly lower (P<0.05). Under comprehensive treatments plus compound amino acids and large doses of vitamin B₆, the bleeding was gradually under control within 1.5-72 hours. The most quick speed for control of the bleeding was within 1 hour in one patient. The liver function was markedly improved.

Novel therapy combined with use of compound amino acids and large doses of vitamin B₆ is feasible in the treatment of patients with severe traumatic coagulopathy.