切换至 "中华医学电子期刊资源库"

中华卫生应急电子杂志 ›› 2019, Vol. 05 ›› Issue (02) : 71 -79. doi: 10.3877/cma.j.issn.2095-9133.2019.02.002

所属专题: 文献

论著

新疆克孜勒苏柯尔克孜自治州三个民族急性心肌梗死患者的临床特征和冠状动脉病变特点的分析
毕超1, 姜婷2, 王魏魏2, 李春雨3, 陈君4, 赵鹏程1, 曹瑞莹1, 陈彦5,()   
  1. 1. 210029 江苏南京,南京医科大学第一附属医院急诊中心
    2. 210029 江苏南京,南京医科大学第一附属医院重症医学科
    3. 210036 江苏南京,江苏省妇幼保健院重症医学科
    4. 210006 江苏南京,南京医科大学附属南京市第一医院急诊中心
    5. 210029 江苏南京,南京医科大学第一附属医院急诊中心;845350 新疆维吾尔自治区,克孜勒苏柯尔克孜自治州人民医院医务部
  • 收稿日期:2019-03-25 出版日期:2019-04-18
  • 通信作者: 陈彦
  • 基金资助:
    国家自然科学基金(81571873); 自治区区域协同创新专项(科技援疆计划)(2018E02097); 自治区科技计划项目(2018D07025)

Clinical characteristics of coronary artery lesions in patients with acute myocardial infarction in three ethnic groups in Kizilsu Kirgiz Autonomous Prefecture of Xinjiang Uygur Autonomous Region

Chao Bi1, Ting Jiang2, Weiwei Wang2, Chunyu Li3, Jun Chen4, Pengcheng Zhao1, Ruiying Cao1, Yan Chen5,()   

  1. 1. Emergency Center, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
    2. Intensive Care Unit, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
    3. Intensive Care Unit, Women and Children Health Care Hospital of Jiangsu Province, Nanjing 210036, China
    4. Emergency Center, the Affiliated Nanjing First Hospital of Nanjing Medical University, Nanjing 210006, China
    5. Emergency Center, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China; Department of Medical Affairs, Kizilsu Kirgiz Autonomous Prefecture People’s Hospital, Xinjiang Uygur Autonomous Region, Xinjiang 845350, China
  • Received:2019-03-25 Published:2019-04-18
  • Corresponding author: Yan Chen
  • About author:
    Corresponding author: Chen Yan, Email:
引用本文:

毕超, 姜婷, 王魏魏, 李春雨, 陈君, 赵鹏程, 曹瑞莹, 陈彦. 新疆克孜勒苏柯尔克孜自治州三个民族急性心肌梗死患者的临床特征和冠状动脉病变特点的分析[J]. 中华卫生应急电子杂志, 2019, 05(02): 71-79.

Chao Bi, Ting Jiang, Weiwei Wang, Chunyu Li, Jun Chen, Pengcheng Zhao, Ruiying Cao, Yan Chen. Clinical characteristics of coronary artery lesions in patients with acute myocardial infarction in three ethnic groups in Kizilsu Kirgiz Autonomous Prefecture of Xinjiang Uygur Autonomous Region[J]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2019, 05(02): 71-79.

目的

探讨新疆克孜勒苏柯尔克孜自治州(新疆克州)汉族、维吾尔族(维族)和柯尔克孜族(柯族)急性心肌梗死(AMI)患者的临床特征及其冠状动脉病变特点。

方法

收集2017年1月至2019年1月在南京医科大学附属克州人民医院临床考虑急性心肌梗死行冠状动脉造影确诊为AMI的病例,并进行回顾性研究,其中男性150例,女性42例;年龄30~89岁,平均(61.99±12.07)岁。根据民族不同,将全体患者分为汉族组(40例)、维族组(100例)与柯族组(52例),将男性患者分为汉族男性组(28例)、维族男性组(78例)与柯族男性组(44例);根据年龄不同,将患者分为青年组(年龄≤44周岁,14例)与非青年组(年龄>44周岁,178例);根据病情转归预后不同,将患者分为生存组(167例)与死亡组(25例)。分析汉族、维族和柯族三组患者的体重指数(body mass index,BMI)、饮酒史、动脉血压、白细胞计数(white blood cell,WBC)、红细胞计数(red blood cell,RBC)、血红蛋白(hemoglobin,Hb)、血小板计数(platelet,PLT);心肌肌钙蛋白T(cardiac troponin T,cTnT)、同型半胱氨酸(homocysteine,Hcy)、B型脑钠肽( B-type natriuretic peptide,BNP)等临床特征,比较汉族、维族和柯族三组患者之间,汉族男性、维族男性与柯族男性三组患者之间,青年组与非青年组患者之间,生存组与死亡组患者之间病变血管支数分布、罪犯血管分布、冠脉病变分型分布及Gensini评分。

结果

共纳入192例AMI患者,其中汉族40例(20.83%),维吾尔族100例(52.08%),柯族52例(27.08%)。(1)少数民族(维族和柯族)患者体重指数(BMI)水平高于汉族组患者(P均<0.05);少数民族两组患者饮酒率高于汉族组患者(P均<0.017);少数民族患者红细胞(RBC)计数、血小板(PLT)计数及心肌肌钙蛋白T(cTnT)水平均高于汉族组患者(P均<0.05)。(2)柯族组患者血压>维族组患者血压>汉族组患者血压(P均<0.05)。(3)维族组患者白细胞(WBC)计数高于汉族组患者(P<0.05);维族组患者同型半胱氨酸(Hcy)水平高于柯汉两族组患者(P均<0.05);柯族组患者B型脑钠肽(BNP)水平高于汉族组患者(P<0.05)。(4)维汉两族组患者三支病变比例高于柯族组患者(P均<0.05),柯族组患者单支病变比例高于维汉两族组患者(P均<0.05);青年组患者单支病变最为多见,单支病变比例高于非青年组患者(P<0.05),而非青年组患者以三支病变最为多见,非青年组患者三支病变比例高于青年组患者(P<0.05);维汉两族组患者Gensini评分高于柯族组患者(P<0.05);生存组患者Gensini评分低于死亡组患者(P均<0.05)。

结论

新疆克州地区汉族、维族及柯族三个民族AMI患者间临床特征及冠脉病变特点存在差异,维族、汉族AMI患者的三支病变的发病率均较柯族高,冠脉病变严重程度均较柯族重。在临床工作中,对于不同民族的AMI患者,应采取有针对性的个体化防治措施。

Objective

To investigate clinical features and characteristics of coronary artery lesions of Han, Uygur and Khalkhas patients with acute myocardial infarction (AMI) in Kizilsu Kirgiz Autonomous Prefecture of Xinjiang Uygur Autonomous Region.

Methods

A retrospective study was conducted among the patients diagnosed with AMI and performed coronary angiography between January 2017 and January 2019 in Kizilsu Kirgiz Autonomous Prefecture People’s Hospital. There were 150 males and 42 females, aged from 30 to 89 years, with an average age of (61.99±12.07) years old. According to different ethnic groups, the patients were divided into Han group (40 cases), Uygur group (100 cases) and Kirgiz group (52 cases). Male patients were divided into Han male group (28 cases), Uyghur male group (78 cases) and Kirgiz male group (44 cases); according to different ages, the patients were divided into the youth group (age ≤ 44 years old, 14 cases) and the non-youth group (age>44 years old, 178 cases); according to the outcome of the disease, the patients were divided into the survival group (167 cases) and the death group (25 cases). The clinical characteristics of Han, Uygur and Kirgiz, including body mass index (BMI), drinking history, arterial blood pressure, white blood cell count (WBC), red blood cell count (RBC), hemoglobin (Hb), platelet count (PLT), cardiac troponin T (cTnT), homocysteine (Hcy), and type B brain natriuretic peptide (BNP), were analyzed. The distribution of diseased vessels, the distribution of criminal blood vessels, the distribution of coronary lesions and Gensini score between groups were compared.

Results

A total of 192 patients with AMI were enrolled, including 40 cases of Han, 100 cases of Uygur, and 52 cases of kirgiz. The body mass index(BMI) levels of the two minority groups were higher than that of Han group(P<0.05); the drinking rates of the two minority groups were higher than that of Han group(P<0.017); the counts of red blood cells (RBC) and platelets(PLT), the levels of cardiac troponin T(cTnT) were higher in the two minority groups than that in Han group(P<0.05). Blood pressure in Kirgiz group was higher than that in Uygur group and Han group (P<0.05). The count of white blood cells (WBC) in Uygur group was higher than that in Han group(P<0.05); the level of homocysteine(Hcy) in Uygur group was higher than that in Kirgiz and Han groups (P<0.05); the level of B-type natriuretic peptide(BNP) in Kirgiz group was higher than that in Han group(P<0.05). The proportion of three-vessel disease in Uygur and Han groups was higher than that in Kirgiz group(P<0.05) and the proportion of single-vessel disease in Kirgiz group was higher than that in Uygur and Han groups(P<0.05); the single-vessel disease was the most common in the youth group, and the proportion of single-vessel disease was higher than that in the non-youth group(P<0.05); the three-vessel disease was the most common in the non-youth group, which had a higher proportion of three-vessel disease than the young group (P<0.05); the Gensini scores of patients in Uygur and Han group were higher than that in Kirgiz group(P<0.05); the Gensini score in the survival group was lower than that in the death group(P<0.05).

Conclusions

There are ethnic differences in clinical features and coronary lesions among AMI patients in Kizilsu Kirgiz Autonomous Prefecture of Xinjiang Uygur Autonomous Region. The incidence of three-vessel disease in Uygur and Han patients with AMI is higher than that of Kirgiz and the severity of coronary artery lesions is heavier than that of Kirgiz. In clinical practice, targeted individualized prevention and treatment measures should be taken for AMI patients of different races.

表1 三个民族AMI患者一般情况及临床特征比较[例,(%)]
组别 例数 年龄(岁) 男性 BMI(kg/m2) 吸烟史 饮酒史 既往PCI史
汉族 40 63.20±12.89 28(70.00) 20(17~22) 12(30.00) 4(10.00) 0(0.00)
维族 100 61.62±12.04 78(78.00) 23(18~28) 22(22.00) 31(31.00) 7(7.00)
柯族 52 61.77±11.64 44(84.60) 23(20~25) 16(30.80) 17(32.70) 4(7.70)
F2/H ? 0.26 2.83 57.28 1.78 7.52 3.24
P ? P>0.05 P>0.05 P<0.05ab P>0.05 P<0.05de P>0.05
组别 例数 冠心病家族史 高血压 糖尿病 慢性肾病 高胆固醇血症 高甘油三酯血症
汉族 40 4(10.00) 24(60.00) 8(20.00) 4(10.00) 13(32.50) 4(10.00)
维族 100 3(3.00) 37(37.00) 22(22.00) 2(2.00) 38(38.00) 13(13.00)
柯族 52 4(7.70) 22(42.30) 4(7.70) 2(3.80) 18(34.60) 4(7.70)
χ2 ? 3.40 6.18 4.99 4.15 0.43 1.04
P ? P>0.05 P<0.05d P>0.05 P>0.05 P>0.05 P>0.05
组别 例数 SBP(mmHg) DBP(mmHg) WBC(*10^9/L) NE%(%) RBC(*10^12/L) Hb (g/L)
汉族 40 115(80~140) 75(50~90) 7.42 (5.32~9.91) 79.20(56.20~92.51) 4.16(3.21~5.36) 139(89~165)
维族 100 130(80~200) 80(50~120) 9.58(4.06~25.24) 75.12(50.00~92.20) 4.92 (2.92~7.38) 143(66~362)
柯族 52 130(120~200) 90(70~120) 8.08(5.00~17.70) 75.83(56.38~90.00) 4.90 (3.65~6.32) 145(135~190)
H ? 34.21 27.20 16.10 2.77 22.39 4.94
P ? P<0.05abc P<0.05abc P<0.05a P>0.05 P<0.05ab P>0.05
组别 例数 PLT(*10^9/L) TC(mmol/L) TG(mmol/L) LDL-C(mmol/L) HDL-C(mmol/L) LP(a)(mg/L)
汉族 40 190(138~299) 4.08(2.30~5.16) 1.23(0.96~2.46) 2.76(1.03~3.43) 1.17(0.47~1.24) 105.02(54.00~837.00)
维族 100 256(109~566) 4.13(2.36~6.73) 1.25(0.61~4.29) 2.63(1.21~5.35) 1.09(0.58~1.52) 149.00(18.20~1156.40)
柯族 52 255(125~363) 4.27(2.96~5.16) 1.26(0.77~2.68) 2.76(1.70~8.25) 1.11(0.80~1.38) 128.00(38.10~541.20)
H ? 18.39 5.35 0.05 0.31 5.83 4.03
P ? P<0.05ab P>0.05 P>0.05 P>0.05 P>0.05 P>0.05
组别 例数 apoAⅠ(mmol/L) apoB(mmol/L) UA(μmol/L) Cr(μmol/L) CRP(mg/L) Hcy(μmol/L)
汉族 40 0.97(0.50~1.07) 0.84(0.57~1.39) 303.10(191.00~494.00) 88.65(53.90~119.90) 22.56(1.16~168.11) 11.10(7.40~48.20)
维族 100 0.96(0.44~1.88) 0.85(0.39~1.69) 322.00(41.70~592.00) 88.66(43.80~497.00) 22.12(0.12~196.87) 13.70(7.30~50.70)
柯族 52 1.00(0.55~1.22) 0.85(0.73~1.23) 306.00(178.00~539.00) 87.16(55.20~170.02) 22.80(0.40~64.00) 11.20(7.00~15.10)
H ? 2.95 0.08 2.78 0.42 3.08 16.05
P ? P>0.05 P>0.05 P>0.05 P>0.05 P>0.05 P<0.05ac
组别 例数 PT(s) APTT(s) FIB(g/L) D-二聚体(mg/L) cTnT (ng/L) BNP(ng/L)
汉族 40 12.60(11.00~56.20) 28.2(22.6~50.7) 2.60(2.08~7.50) 0.86(0.10~61.50) 0.86(0.04~28.97) 123.36(10.36~1213.00)
维族 100 12.22(10.60~24.80) 25.3(15.3~86.6) 3.03(1.89~7.90) 0.57(0.01~88.20) 3.22(0.03~200.00) 240.31(7.75~2125.50)
柯族 52 12.23(10.50~17.70) 25.7(19.9~39.5) 3.17(1.69~12.20) 1.02(0.24~19.36) 3.66(0.09~48.79) 1 096.32(86.66~2000.00)
H ? 1.59 4.36 3.24 1.88 14.56 9.83
P ? P>0.05 P>0.05 P>0.05 P>0.05 P<0.05ab P<0.05b
表2 三个民族AMI患者冠脉病变特点比较
表3 三个民族男性AMI患者冠脉病变特点比较
表4 青年组与非青年组AMI患者冠脉病变特点比较
表5 生存组与死亡组AMI患者冠脉病变特点比较
1
Thygesen K, Alpert JS, Jaffe AS, et al.Third universal definition of myocardial infarction[J].Circulation,2012,60(16):2020-2035.
2
Thygesen K, Alpert JS, Jaffe AS, et al.Fourth universal definition of myocardial infarction (2018)[J].Circulation,2018,138(20):e618-e651.
3
Reed GW, Rossi JE, Cannon CP.Acute myocardial infarction[J].Lancet,2017,389(10065):197-210.
4
Benjamin EJ, Muntner P, Alonso A, et al.Heart disease and stroke statistics-2019 update:a report from the american heart association[J].Circulation,2019,139(10):e56-e528.
5
王文,朱曼璐,王拥军,等.《中国心血管病报告2012》概要[J].中国循环杂志,2013,28(6):408-412.
6
陈伟伟,高润霖,刘力生,等.《中国心血管病报告2017》概要[J].中国循环杂志,2018,33(1):1-8.
7
刘浩,武刚,翟雪芹,等.早发冠心病急性心肌梗死的危险因素及临床特点分析[J].中国全科医学,2012,15(11):1205-1208.
8
曲凌光,尚佳,葛利军,等.回族与汉族早发冠心病冠状动脉病变及心血管危险因素的比较分析[J].中国循证医学杂志,2013,13(7):797-800.
9
Gijsberts CM, Seneviratna A, de Carvalho LP, et al.Ethnicity modifies associations between cardiovascular risk factors and disease severity in parallel dutch and singapore coronary cohorts[J].PLoS One,2015,10(7): e0132278.
10
中华医学会心血管病学分会,中华心血管病杂志编辑委员会.推荐在我国采用心肌梗死全球统一定义[J].中华心血管病杂志,2008,36(10):867-869.
11
中国成人血脂异常防治指南制定联合委员会.中国成人血脂异常防治指南[J].中华心血管病杂志,2007,35(5):390-419.
12
《中国高血压防治指南》修订委员会.中国高血压防治指南2018年修订版[J].心脑血管病防治,2019,19(1):1-44.
13
中华医学会糖尿病分会.中国2型糖尿病防治指南(2017年版)[J].中国实用内科杂志,2018,38(4):292-344.
14
中国肥胖问题工作组.中国成人超重和肥胖症预防与控制指南(节录)[J].营养学报,2004,26(1):1-4.
15
Wang J, Liu ZQ, He PY, et al.Analysis of the risk factors and characteristics of coronary artery disease of han,uygur and kazak patients with acute myocardial infarction in xinjiang district[J].Int J Clin Exp Med,2015,8(2):2831-2838.
16
Judkins MP.Selective coronary arteriography.I.A percutaneous transfemoral technic[J].Radiology,1967,89(5):815-824.
17
Guidelines for percutaneous transluminal coronary angioplasty.A report of the american college of cardiology/american heart association task force on assessment of diagnostic and therapeutic cardiovascular procedures (subcommittee on percutaneous transluminal coronary angioplasty)[J].J Am Coll Cardiol,1988,12(2):529-545.
18
Gensini GG.A more meaningful scoring system for determining the severity of coronary heart disease[J].Am J Cardiol,1983,51(3):606.
19
刘阳,周涵黎,黄光强,等.洋葱多肽及蛋白对T2DM小鼠降血糖及降血脂作用研究[J].食品科技,2017,42(9):227-232.
20
赵青跃,胡进明.高原不同海拔地区正常人血压变化的分析[J].青海医药杂志,2010,40(7):25-26.
21
王晓明,陈念,石红玲.冠状动脉解剖、供血特点与常见冠状动脉病变及其心电图特征[J/CD].心电图杂志(电子版),2014,3(3):182-186.
22
Makaryus AN, Jauhar R, Tortez LM, et al.Comparison of the diameters of the major epicardial coronary arteries by angiogram in asian-indians versus european americans <40 years of age undergoing percutaneous coronary artery intervention[J].Am J Cardiol,2017,120(6):924-926.
23
黄文军,刘俊明,谢伟,等.汉族、维吾尔族、哈萨克族冠心病患者冠状动脉病变的临床研究[J].中国介入心脏病学杂志,2012,20(4):212-216.
24
曲凌光.回族与汉族冠心病危险因素和冠脉病变特点对比分析[D].银川:宁夏医科大学,2013.
25
江时森,吕磊,Juergens C,等.中国人和澳大利亚人冠状动脉病变对比研究[J].中华心血管病杂志,2007,35(5):447-450.
26
Jinnouchi H, Sakakura K, Wada H, et al.Clinical features of myocardial infarction in young japanese patients[J].Int Heart J,2013,54(3):123-128.
27
程桂芬.心肌梗塞发生部位的临床分析[J].实用心脑肺血管病杂志,1997,5(2):61.
28
罗仁,茶春喜,梁金排.不同年龄组维吾尔族与汉族冠心病患者的危险因素与冠状动脉病变特征分析[J].重庆医学,2014,43(4):445-447,450.
29
刘博,张源明.乌鲁木齐地区维吾尔族与汉族早发冠心病患者危险因素相关研究[J].中华实用诊断与治疗杂志,2011,25(3):243-244+247.
30
Wong CP, Loh SY, Loh KK, et al.Acute myocardial infarction: Clinical features and outcomes in young adults in Singapore[J].World J Cardiol,2012,4(6):206-210.
31
Pang J, Zhang Z, Zheng T, et al.The clinical, angiographic and prognosis characteristics of elderly patients with acute ST-segment elevation myocardial infarction--the first elderly STEMI population study in northwest China[J].Int J Cardiol,2015,179:326-328.
32
Chua SK, Hung HF, Shyu KG, et al.Acute ST-elevation myocardial infarction in young patients:15 years of experience in a single center[J].Clin Cardiol,2010,33(3):140-148.
33
苏玉娟,李春雨,姜婷,等.新疆维吾尔自治区克州地区三个民族急性心肌梗死患者的危险因素分析[J/CD].中华卫生应急电子杂志,2018,4(4):204-211.
[1] 薛艳玲, 马小静, 谢姝瑞, 何俊, 夏娟, 何亚峰. 左心声学造影在急性心肌梗死合并室间隔穿孔中的应用价值[J]. 中华医学超声杂志(电子版), 2023, 20(10): 1036-1039.
[2] 缪黄泰, 李潇颖, 张明, 聂绍平. 急性心肌梗死后心脏破裂患者院内死亡的危险因素分析[J]. 中华危重症医学杂志(电子版), 2023, 16(03): 187-192.
[3] 石海杰, 陈秋霞. 海南省苗族新生儿葡萄糖-6-磷酸脱氢酶缺乏症发病情况及基因特征分析[J]. 中华妇幼临床医学杂志(电子版), 2021, 17(03): 278-283.
[4] 张艺山, 莫丹, 蒋依玲, 邓思成, 吴冬燕, 黄华, 邱荣敏. 广西百色市壮、汉族儿童口腔健康行为比较及风险因素分析[J]. 中华口腔医学研究杂志(电子版), 2023, 17(03): 172-179.
[5] 乔梁, 杨向群. 脂肪干细胞在心肌损伤修复中的研究进展[J]. 中华细胞与干细胞杂志(电子版), 2022, 12(04): 230-236.
[6] 吴彬阁, 何婧, 常颖, 赵世强, 接英. 内蒙古自治区包头市各民族青少年眼部生物学参数的临床研究[J]. 中华眼科医学杂志(电子版), 2022, 12(01): 31-36.
[7] 谢靖芸, 李准. 院前急救对AMI患者治疗及预后影响的Meta分析[J]. 中华临床医师杂志(电子版), 2022, 16(09): 869-875.
[8] 赵宁, 陈娟媚, 杨其霖, 莫沛. 急性心肌梗死患者住院病死率和纤维蛋白原水平的非线性关系[J]. 中华临床实验室管理电子杂志, 2023, 11(01): 32-37.
[9] 左汉恒, 李银平, 张程征, 朱文雅. 酷似扩张型心肌病的急性心肌梗死诊断特征并文献复习[J]. 中华诊断学电子杂志, 2022, 10(02): 88-93.
[10] 杨沭, 郦明芳, 陈明龙. 左心室血栓的研究进展[J]. 中华心脏与心律电子杂志, 2023, 11(03): 188-192.
[11] 张林叶, 柏战, 王宗方, 潘文君. GRACE 2.0评分对老年急性心肌梗死患者经皮冠状动脉介入治疗后急性肾损伤的预测价值[J]. 中华老年病研究电子杂志, 2022, 09(04): 6-11.
[12] 祁春雷, 翁川晴, 刘念念, 王信淳, 苏俊伟, 肖平喜. Takotsubo综合征患者系统氧化应激与心脏功能相关性研究[J]. 中华卫生应急电子杂志, 2022, 08(03): 134-140.
[13] 魏盈盈, 潘鑫, 李岑, 曹俊辉, 顾慧, 王忻, 杨声远. 基于胸痛中心急救流程在急性心肌梗死患者救治中的应用[J]. 中华卫生应急电子杂志, 2022, 08(02): 86-88.
[14] 罗燕飞, 热衣兰木·包尔汉, 迪丽胡麻·居来提, 栗俊康, 玛依拉·阿不都热依木, 孙光辉, 栾磊新, 米热古丽·买买提. 新疆和田地区维吾尔族儿童单纯性肥胖危险因素调查[J]. 中华肥胖与代谢病电子杂志, 2022, 08(02): 116-122.
[15] 何偲, 鄢华. 妊娠期缺血性心脏病的研究进展[J]. 中华脑血管病杂志(电子版), 2021, 15(04): 263-266.
阅读次数
全文


摘要