切换至 "中华医学电子期刊资源库"

中华卫生应急电子杂志 ›› 2020, Vol. 06 ›› Issue (04) : 233 -238. doi: 10.3877/cma.j.issn.2095-9133.2020.04.008

所属专题: 文献

论著

血清中8-OHdG、MDA、SOD和T-AOC对脑卒中患者的诊断价值
龙云霞1,()   
  1. 1. 266300 山东胶州,胶州市人民医院检验科
  • 收稿日期:2019-09-27 出版日期:2020-08-18
  • 通信作者: 龙云霞

Diagnostic value of serum 8-OHdG, MDA, SOD and T-AOC in patients with stroke

Yunxia Long1,()   

  1. 1. Department of Laboratory, Jiaozhou People’s Hospital, Jiaozhou 266300, China
  • Received:2019-09-27 Published:2020-08-18
  • Corresponding author: Yunxia Long
  • About author:
    Corresponding author: Long Yunxia, Email:
引用本文:

龙云霞. 血清中8-OHdG、MDA、SOD和T-AOC对脑卒中患者的诊断价值[J/OL]. 中华卫生应急电子杂志, 2020, 06(04): 233-238.

Yunxia Long. Diagnostic value of serum 8-OHdG, MDA, SOD and T-AOC in patients with stroke[J/OL]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2020, 06(04): 233-238.

目的

分析血清中8-OHdG、MDA、SOD和T-AOC对脑卒中患者的诊断价值。

方法

采用酶联免疫吸附试验(ELISA)测定缺血性脑卒中(IS)102例、出血性脑卒中(ICH)98例和正常对照组95例血清8-羟基脱氧鸟苷酸(8-OHdG)、丙二醛(MDA)、超氧化物歧化酶(SOD),采用菲啉类物质比色法检测三组总抗氧化能力(T-AOC)。用ROC曲线下面积分析8-OHdG、MDA、SOD和T-AOC在脑卒中的诊断价值。

结果

IS和ICH组血清8-OHdG和MDA水平均高于正常对照组(P<0.05),SOD和T-AOC水平均低于正常对照组(P<0.05)。IS组血清8-OHdG、SOD和T-AOC水平高于ICH组(P<0.05),而两组之间MDA水平无统计学差异(P>0.05);8-OHdG与MDA、SOD和T-AOC水平呈正相关(P<0.01),MDA与SOD无相关性(P>0.05),MDA与T-AOC呈正相关(P<0.05)。8-OHdG、MDA、SOD和T-AOC诊断IS与健康者的特异性分别为84%,82%,89%,91%。8-OHdG、MDA、SOD和T-AOC诊断ICH与健康者的特异性分别为71%,84%,79%,72%。8-OHdG和T-AOC与脑卒中密切相关且是脑卒中的保护性因素;MDA和SOD与脑卒中密切相关且是脑卒中的危险因素。

结论

血清8-OHdG、MDA、SOD和T-AOC是脑卒中患者发生氧化应激的灵敏指标。8-OHdG、SOD和T-AOC水平与脑卒中病情有明显相关度,对脑卒中患者的鉴别诊断具有较高实用价值。

Objective

To analyze the diagnostic value of 8-OHdG, MDA, SOD and T-AOC in patients with stroke.

Methods

The levels of serum 8-hydroxydeoxyguanosine monophosphate (8-OHdG), malondialdehyde (MDA) and superoxide dismutase (SOD) in 102 cases of ischemic stroke (IS group), 98 cases of hemorrhagic stroke (ICH group) and 95 healthy subjects (the normal control group), were detected by enzyme-linked immunosorbent assay (ELISA). Total antioxidant capacity (T-AOC) of three groups was detected by phenanthroline colorimetric method. The area under the ROC curve was used to analyze the diagnostic value of 8-OHdG, MDA, SOD and T-AOC in stroke.

Results

Serum 8-OHdG and MDA levels in the IS and ICH groups were higher than that of the normal control group (P<0.05). SOD and T-AOC levels in the IS and ICH groups were lower than that of the normal control group (P<0.05). The levels of serum 8-OHdG, SOD and T-AOC in the IS group were higher than those in the ICH group (P<0.05), while there was no significant difference between the two groups (P>0.05). 8-OHdG was positively correlated with MDA, SOD, T-AOC levels (P<0.01), MDA was not correlated with SOD (P>0.05), and MDA was positively correlated with T-AOC (P <0.05). The specificity of 8-OHdG, MDA, SOD and T-AOC in diagnosing IS and healthy subjects was 84%, 82%, 89% and 91%, respectively. The specificity of 8-OHdG, MDA, SOD and T-AOC in the diagnosis of ICH and healthy persons was 71%, 84%, 79% and 72%, respectively. 8-OHdG and T-AOC were closely related to stroke and protective factors for stroke. MDA and SOD were closely related to stroke and are risk factors for stroke.

Conclusion

Serum 8-OHdG, MDA, SOD and T-AOC are sensitive indicators of oxidative stress in stroke patients. The levels of 8-OHdG, SOD and T-AOC are significantly correlated with the severity of stroke, and have a high practical value for the differential diagnosis of stroke patients.

表1 IS 组、ICH组和正常对照组血清8-OHdG、MDA、SOD和T-AOC水平的比较(±s)
图1 8-OHdG、MDA、SOD 和T-AOC诊断IS与健康者的ROC曲线
表2 8-OHdG、MDA、SOD 和T-AOC诊断IS与健康者的AUC、灵敏度、特异度和截断值
图2 8-OHdG、MDA、SOD 和T-AOC诊断ICH与健康者的ROC曲线
表3 8-OHdG、MDA、SOD 和T-AOC诊断ICH与健康者的AUC、灵敏度、特异度和截断值
图3 8-OHdG 与MDA的相关性分析
图4 8-OHdG 与SOD的相关性分析
图5 8-OHdG 与T-AOC的相关性分析
图6 MDA 与SOD的相关性分析
图7 MDA 与T-AOC的相关性分析
表4 脑卒中严重程度相关的多因素Logistic回归分析
1
Tay SY, Ampil ER, Chen CP,et al.The relationship between homocysteine,cognition and stroke subtypes in acute stroke[J].J Neurol Sci,2006,250(1-2):58-61.
2
万芳,高应东.缺血修饰白蛋白的临床应用进展[J].标记免疫分析与临床,2017,24(7):823-826.
3
徐蔚,许红静.老年脑卒中患者围治疗期血清同型半胱氨酸及血脂水平变化的分析[J].国际检验医学杂志,2018,39(6):655-657.
4
邓洪,潘超,唐洲平.脑出血后脑血流低灌注的临床研究进展[J].中华神经科杂志,2018,51(4):304-307.
5
Woodruff TM, Thundyil J, Tang SC,et al.Pathophysiology,treatment,and animal and cellular models of human ischemic stroke[J].Mol Neurodegener,2011,6(1):11.
6
Matuso Y, Kihara T, Ikeda M,et al.Role of neutrophils in radical production during ischemia and reperfusion of the rat brain:effect of neutrophil depletion on extracellular ascorbyl radical formation[J].J Cereb Blood Flow Metab,1995,15(6):941-947.
7
张斯萌,王文,黄丹,等.急性脑卒中患者血清氧化应激指标测定及临床意义[J].微循环学杂志,2012,22(4):42-43.
8
李美珠,朱嫦琳,梁指荣,等.血清8-羟基脱氧鸟苷酸在急性脑梗死诊断中的应用[J].广东医学,2015,36(20):3191-3193.
9
Saiki R, Park H, Ishii I,et al.Brain infarction correlates more closely with acrolein than with reactive oxygen species[J].Biochem Biophys Res Commun,2011,404(4):1044-1049.
10
尹义军,汪宏良,左芳.进展性脑梗死患者血清氧化应激指标的动态观察[J].国际检验医学杂志,2013,34(6):664-665.
11
李美珠,朱嫦琳,黄淑萱,等.脑卒中患者血清中氧化应激指标的检测及临床意义[J].检验医学,2016,31(01):38-41.
12
Moon GJ, Kim SJ, Cho YH,et al.Antioxidant effects of statins in patients with atherosclerotic cerebrovascular disease[J].J Clin Neurol,2014,10(2):140-147.
13
田甜.脑卒中家族史、饮茶与缺血性脑卒中发病风险的前瞻性队列研究[D].南京:南京医科大学,2017.
14
张颖.急性脑梗死患者急性期血清OPN、氧化应激水平的变化及其与神经损伤和预后的关系[J].广东医学,2017,38(9):1386-1389.
15
秦勇,周一心,詹青,等.Lp-PLA2与高血压患者发生缺血性脑卒中及预后的相关性分析[J].国际检验医学杂志,2018,39(2):163-165.
[1] 王亚红, 蔡胜, 葛志通, 杨筱, 李建初. 颅骨骨膜窦的超声表现一例[J/OL]. 中华医学超声杂志(电子版), 2024, 21(11): 1089-1091.
[2] 唐金侨, 叶宇佳, 王港, 赵彬, 马艳宁. 医学影像学检查方法在颞下颌关节紊乱病中临床应用研究进展[J/OL]. 中华口腔医学研究杂志(电子版), 2024, 18(06): 406-411.
[3] 赵林娟, 吕婕, 王文胜, 马德茂, 侯涛. 超声引导下染色剂标记切缘的梭柱型和圆柱型保乳区段切除术的效果研究[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 634-637.
[4] 屈翔宇, 张懿刚, 李浩令, 邱天, 谈燚. USP24及其共表达肿瘤代谢基因在肝细胞癌中的诊断和预后预测作用[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 659-662.
[5] 熊鹰, 林敬莱, 白奇, 郭剑明, 王烁. 肾癌自动化病理诊断:AI离临床还有多远?[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(06): 535-540.
[6] 袁雨涵, 杨盛力. 体液和组织蛋白质组学分析在肝癌早期分子诊断中的研究进展[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 883-888.
[7] 中华医学会器官移植学分会. 肝移植术后缺血性胆道病变诊断与治疗中国实践指南[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 739-748.
[8] 郑大雯, 王健东. 胆囊癌辅助诊断研究进展[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 769-773.
[9] 王秋生. 胆道良性疾病诊疗策略[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 779-782.
[10] 李浩, 陈棋帅, 费发珠, 张宁伟, 李元东, 王硕晨, 任宾. 慢性肝病肝纤维化无创诊断的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(09): 863-867.
[11] 谭瑞义. 小细胞骨肉瘤诊断及治疗研究现状与进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(08): 781-784.
[12] 王子阳, 王宏宾, 刘晓旌. 血清标志物对甲胎蛋白阴性肝细胞癌诊断的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 677-681.
[13] 陈慧, 邹祖鹏, 周田田, 张艺丹, 张海萍. 皮肤镜对头皮红斑性皮肤病辅助鉴别诊断的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 692-698.
[14] 胡云鹤, 周玉焯, 付瑞瑛, 于凡, 李爱东. CHS-DRG付费制度下GB1分组住院费用影响因素分析与管理策略探讨[J/OL]. 中华临床医师杂志(电子版), 2024, 18(06): 568-574.
[15] 耿晓坤. 缺血性卒中后无效再灌注的时间窗、组织窗与神经保护[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(06): 636-636.
阅读次数
全文


摘要