脓毒症相关的铁死亡研究知识图谱分析

doi:10.3877/cma.j.issn.2095-9133.2025.05.009

目的

分析脓毒症背景下"铁死亡"概念自出现至今的研究热点、发展趋势及各个国家、作者及机构之间的合作交流情况。

方法

本研究运用文献计量学的方法借助CiteSpace、VOSviewer、RStudio、Excel等软件多角度分析脓毒症领域中铁死亡研究的关键词、国家及机构、作者、文献共被引等信息并以知识图谱的形式进行展现。

结果

在Web of Science的核心合集中共收集324篇文献，1 378个关键词。其中发文量排名前5的国家依次是中国、美国、德国、泰国、法国；关键词共现排序前3的是炎症、氧化应激和急性肺损伤；所有关键词聚类Modularity Q值为0.7483，Silhouette S值0.9067；关键词突现中最具时间依赖性的是"Iron overload"，近期热点关键词有"autophagy"、"septic shock"、"infammation"；文献共被引分析中以Dixon、Stockwell团队引用率最高；国家及机构分析可知中国及美国在该领域的研究热度最高；文章被引次数最多的期刊是"Free radical biology and medicine"，期刊之间链接强度最高的是"Frontiers in immunology"，发文数量最多的期刊是"International immunopharmacology"。

结论

脓毒症相关的铁死亡研究热点为抑制铁死亡的发生、循坏系统功能障碍、脏器的损伤及保护、炎症反应、氧化应激等方向；这个领域中，中国与美国的学术影响力最大且差距正在缩小，但中国科研机构在国内和国际的合作网络尚未建立，需继续努力探寻跨学科、跨机构合作的新道路。

关键词: 脓毒症, 铁死亡, 知识图谱

Objective

To analyze the research hotspots and development trends of the concept of 'ferroptosis’ in the context of sepsis, as well as the cooperation and exchange between countries, authors and institutions.

Methods

We used the method of bibliometrics to analyze the keywords, countries and institutions, authors, literature co-citation and other information of ferroptosis research in the field of sepsis from multiple perspectives with the help of CiteSpace, VOSviewer, RStudio, Excel and other software, and showed it in the form of knowledge map.

Results

A total of 324 articles and 1378 keywords were collected in the core collection of Web of Science. The top five countries in terms of the number of publications were China, the United States, Germany, Thailand, and France. The top three keywords were inflammation, oxidative stress and acute lung injury. All keywords clustering modularity Q value was 0.7483, and Silhouette S value was 0.9067; the most time-dependent keyword was 'iron overload’, and the recent hot keywords were 'autophagy’, 'septic shock’ and 'inflammation’. In the literature co-citation analysis, the Dixon and Stockwell teams had the highest citation rate. According to the analysis of countries and institutions, China and the United States had the highest research heat in this field; the journal with the highest number of citations was 'Free Radical Biology and Medicine’, the journal with the highest link strength between journals was 'Frontiers in Immunology’, and the journal with the highest number of publications was 'International Immunopharmacology’.

Conclusion

The research hotspots of sepsis-related ferroptosis are to inhibit the occurrence of ferroptosis, circulatory system dysfunction, organ damage and protection, inflammatory response, oxidative stress, etc. In this field, China and the United States have the largest academic influence and the gap is narrowing. However, the domestic and international cooperation network of Chinese scientific research institutions has not yet been established, and efforts need to continue to explore new ways of interdisciplinary and inter-institutional cooperation.

Key words: Sepsis, Ferroptosis, Knowledge map

图1 Web of Science核心合集中脓毒症铁死亡相关研究发文趋势

表1 Web of Science核心合集中脓毒症铁死亡相关研究发文量

编号	年份	发文篇数
1	2005至2019	35
2	2020	8
3	2021	17
4	2022	57
5	2023	77
6	2024	128

表1 Web of Science核心合集中脓毒症铁死亡相关研究发文量

编号	年份	发文篇数
1	2005至2019	35
2	2020	8
3	2021	17
4	2022	57
5	2023	77
6	2024	128

图2 脓毒症铁死亡研究发文量排名前5的国家及时间分布图

图3 脓毒症铁死亡相关文献中关键词共现图（频次>5）

表2 脓毒症铁死亡相关文献中的高频关键词（频次>10）

序号	关键词	频次	关联强度
1	ferroptosis	213	953
2	sepsis	163	779
3	cell-death	62	360
4	inflammation	57	323
5	oxidative stress	49	250
6	activation	38	229
7	acute lung injury	37	190
8	autophagy	32	221
9	iron	32	195
10	protects	29	197
11	apoptosis	29	159
12	acute kidney injury	28	149
13	metabolism	27	184
14	expression	26	137
15	mechanisms	25	156
16	septic shock	24	115
17	injury	22	107
18	nrf2	19	113
19	lipid-peroxidation	17	87
20	pyroptosis	15	101
21	necroptosis	15	82
22	ferritinophagy	12	70
23	cancer	11	70
24	sepsis-associated encephalopathy	11	42
25	cardiac dysfunction	10	57
26	gpx4	10	51
27	infection	10	49
28	lipid peroxidation	10	48

表2 脓毒症铁死亡相关文献中的高频关键词（频次>10）

序号	关键词	频次	关联强度
1	ferroptosis	213	953
2	sepsis	163	779
3	cell-death	62	360
4	inflammation	57	323
5	oxidative stress	49	250
6	activation	38	229
7	acute lung injury	37	190
8	autophagy	32	221
9	iron	32	195
10	protects	29	197
11	apoptosis	29	159
12	acute kidney injury	28	149
13	metabolism	27	184
14	expression	26	137
15	mechanisms	25	156
16	septic shock	24	115
17	injury	22	107
18	nrf2	19	113
19	lipid-peroxidation	17	87
20	pyroptosis	15	101
21	necroptosis	15	82
22	ferritinophagy	12	70
23	cancer	11	70
24	sepsis-associated encephalopathy	11	42
25	cardiac dysfunction	10	57
26	gpx4	10	51
27	infection	10	49
28	lipid peroxidation	10	48

图4 脓毒症铁死亡相关文献中关键词聚类图

图5 有关脓毒症铁死亡的关键词突现分析图

图6 有关脓毒症铁死亡的文献共被引分布图（共被引频次>20次）注：图中每个节点代表一篇文献，其中最小的节点代表引用次数为20次，节点越大，代表引用次数越多，球体颜色代表研究领域接近。

图7 有关脓毒症铁死亡影响力前10的文献三域图注：CR为参考文献，红色越深代表被引用次数越多；AU为作者，面积越大，颜色越红，代表发文量越多；DE为关键词，面积越大，代表出现次数越多

表3 脓毒症铁死亡影响力前10的文献

文献编号	文献	引用次数	关联强度
1	Dixon SJ，Lemberg KM，Lamprecht MR，et al. Ferroptosis：an iron-dependent form of nonapoptotic cell death[J]. Cell，2012. 149（5）：1060-1072.	129	725
2	Li N，Wang W，Zhou H，et al. Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury[J]. Free Radic Biol Med，2020（160）：303-318.	100	577
3	Singer M，Deutschman CS，Seymour CW，et al. The third international consensus definitions for sepsis and septic shock（Sepsis-3）[J]. JAMA，2016，315（8）：801-810.	83	447
4	Yang WS，SriRamaratnam R，Welsch ME，et al. Regulation of ferroptotic cancer cell death by GPX4[J]. Cell，2014，156（1-2）：317-331.	52	357
5	Wang C，Yuan W，Hu A，et al. Dexmedetomidine alleviated sepsis-induced myocardial ferroptosis and septic heart injury[J].Mol Med Rep，2020，22（1）：175-184.	41	318
6	Fang X，Wang H，Han D，et al. Ferroptosis as a target for protection against cardiomyopathy[J].Proc Natl Acad Sci U S A，2019，116（7）：2672-2680.	46	295
7	Friedmann Angeli JP，Schneider M，Proneth B，et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice[J].Nat Cell Biol，2014，16（12）：1180-1191.	41	294
8	Jiang X，Stockwell BR，Conrad M. Ferroptosis：mechanisms，biology and role in disease[J].Nat Rev Mol Cell Biol，2021，22（4）：266-282.	57	289
9	Wei S，Bi J，Yang L，et al. Serum irisin levels are decreased in patients with sepsis，and exogenous irisin suppresses ferroptosis in the liver of septic mice[J].Clin Transl Med，2020，10（5）：e173.	38	286
10	Stockwell BR，Friedmann Angeli JP，Bayir H，et al. Ferroptosis：a regulated cell death nexus linking metabolism，redox biology，and disease[J]. Cell，2017，171（2）：273-285.	46	284

表3 脓毒症铁死亡影响力前10的文献

文献编号	文献	引用次数	关联强度
1	Dixon SJ，Lemberg KM，Lamprecht MR，et al. Ferroptosis：an iron-dependent form of nonapoptotic cell death[J]. Cell，2012. 149（5）：1060-1072.	129	725
2	Li N，Wang W，Zhou H，et al. Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury[J]. Free Radic Biol Med，2020（160）：303-318.	100	577
3	Singer M，Deutschman CS，Seymour CW，et al. The third international consensus definitions for sepsis and septic shock（Sepsis-3）[J]. JAMA，2016，315（8）：801-810.	83	447
4	Yang WS，SriRamaratnam R，Welsch ME，et al. Regulation of ferroptotic cancer cell death by GPX4[J]. Cell，2014，156（1-2）：317-331.	52	357
5	Wang C，Yuan W，Hu A，et al. Dexmedetomidine alleviated sepsis-induced myocardial ferroptosis and septic heart injury[J].Mol Med Rep，2020，22（1）：175-184.	41	318
6	Fang X，Wang H，Han D，et al. Ferroptosis as a target for protection against cardiomyopathy[J].Proc Natl Acad Sci U S A，2019，116（7）：2672-2680.	46	295
7	Friedmann Angeli JP，Schneider M，Proneth B，et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice[J].Nat Cell Biol，2014，16（12）：1180-1191.	41	294
8	Jiang X，Stockwell BR，Conrad M. Ferroptosis：mechanisms，biology and role in disease[J].Nat Rev Mol Cell Biol，2021，22（4）：266-282.	57	289
9	Wei S，Bi J，Yang L，et al. Serum irisin levels are decreased in patients with sepsis，and exogenous irisin suppresses ferroptosis in the liver of septic mice[J].Clin Transl Med，2020，10（5）：e173.	38	286
10	Stockwell BR，Friedmann Angeli JP，Bayir H，et al. Ferroptosis：a regulated cell death nexus linking metabolism，redox biology，and disease[J]. Cell，2017，171（2）：273-285.	46	284

图8 研究脓毒症铁死亡的主要机构及院校

表4 研究脓毒症铁死亡的主要机构及院校表

机构编号	发文数量	学术中心性	引文半衰期	机构/国家
1	32	10	9.5	USA
2	237	29	4.5	PEOPLES R CHINA
3	3	36	2.5	CANADA
4	2	35	2.5	Cent Penn Clin Special Children & Adults
5	2	21	2.5	Charite
6	2	21	2.5	Emory Univ
7	2	21	2.5	Klinikum Kassel GmbH
8	2	21	2.5	Duke Univ
9	2	21	2.5	DDC Clin Special Needs Children
10	2	21	2.5	Lancaster Gen Hosp
11	2	21	2.5	Dana Farber Boston Childrens Canc & Blood Disorde
12	2	21	2.5	McMaster Univ
13	2	21	2.5	GERMANY
14	2	14	2.5	Stanford Univ
15	2	14	2.5	New York Presbyterian Hosp
16	2	14	2.5	Univ Vermont
17	2	14	2.5	Univ Utah
18	2	14	2.5	Wayne State Univ
19	2	14	2.5	Schwerpunktpraxis Padiatr Hamatol Onkol
20	2	14	2.5	St Jude Childrens Res Hosp
21	2	12	2.5	NETHERLANDS
22	12	9	2.5	Fudan Univ
23	2	8	2.5	FRANCE
24	4	7	2.5	Nanjing Univ
25	4	5	2.5	Nanjing Med Univ
26	5	4	2.5	THAILAND
27	4	1	2.5	Fujian Med Univ

表4 研究脓毒症铁死亡的主要机构及院校表

机构编号	发文数量	学术中心性	引文半衰期	机构/国家
1	32	10	9.5	USA
2	237	29	4.5	PEOPLES R CHINA
3	3	36	2.5	CANADA
4	2	35	2.5	Cent Penn Clin Special Children & Adults
5	2	21	2.5	Charite
6	2	21	2.5	Emory Univ
7	2	21	2.5	Klinikum Kassel GmbH
8	2	21	2.5	Duke Univ
9	2	21	2.5	DDC Clin Special Needs Children
10	2	21	2.5	Lancaster Gen Hosp
11	2	21	2.5	Dana Farber Boston Childrens Canc & Blood Disorde
12	2	21	2.5	McMaster Univ
13	2	21	2.5	GERMANY
14	2	14	2.5	Stanford Univ
15	2	14	2.5	New York Presbyterian Hosp
16	2	14	2.5	Univ Vermont
17	2	14	2.5	Univ Utah
18	2	14	2.5	Wayne State Univ
19	2	14	2.5	Schwerpunktpraxis Padiatr Hamatol Onkol
20	2	14	2.5	St Jude Childrens Res Hosp
21	2	12	2.5	NETHERLANDS
22	12	9	2.5	Fudan Univ
23	2	8	2.5	FRANCE
24	4	7	2.5	Nanjing Univ
25	4	5	2.5	Nanjing Med Univ
26	5	4	2.5	THAILAND
27	4	1	2.5	Fujian Med Univ

图9 刊登脓毒症铁死亡研究领域文章的主要期刊汇总图

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Sepsis-related ferroptosis: a knowledge map analysis

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Sepsis-related ferroptosis: a knowledge map analysis