Brain function changes after fasting in rats being trapped underground

doi:10.3877/cma.j.issn.2095-9133.2015.04.010

Abstract

Abstract:

Objective

To establish a rat model being trapped underground to study the relationship of the energy depletion with brain failure and death after fasting.

Methods

Thirty-six male SD rats were randomly divided into normal diet control group (n=4) and fasting group (provided with water only, n=32). Fasting group was subdivided into 3 d group, 5 d group, 7 d group and 9 d group (n=8 per group) according to the time points of 3, 5, 7 and 9 days after being trapped underground. The changes of the behavior and body weight were observed, and the brain weight and water contents were determined.

Results

Compared with normal diet control group, there were mild excitement and more foraging behavior in 3 d group. There was gradual declining of mental state and body weight in the other three subgroups. There were no statistically significant differences in brain weight between normal diet control group and fasting group until 9 days.

Conclusion

The fasting may exert obvious effect on body weight and brain weight.

Key words: Underground accident, Fasting animal model, Brain dysfunction

Junqing Bai, Guang Cheng, Xiaoping Zhang. Brain function changes after fasting in rats being trapped underground[J]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2015, 01(04): 31-34.

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Figures/Tables 5

References 16

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组别	鼠数	断食前(g)	断食后(g)	脑脏器系数	死亡数(只)
正常组	4	1.82±0.092^ac	－	7.02	0
3 d组	8	－	1.82±0.079	7.78	0
5 d组	8	－	1.80±0.094^b	8.76	0
7 d组	8	－	1.79±0.088^b	9.14	1
9 d组	8	－	1.74±0.070^a	10.60	5

组别	鼠数	断食前(g)	断食后(g)	脑脏器系数	死亡数(只)
正常组	4	1.82±0.092^ac	－	7.02	0
3 d组	8	－	1.82±0.079	7.78	0
5 d组	8	－	1.80±0.094^b	8.76	0
7 d组	8	－	1.79±0.088^b	9.14	1
9 d组	8	－	1.74±0.070^a	10.60	5

组别	鼠数	断食前(g)	断食后(g)	体重变化率(%)	死亡数(只)
正常组	4	353.08±17.12	－	0	0
3 d组	8	357.88±18.58^a	306.89±16.29^b	14.29	0
5 d组	8	355.30±15.90^a	276.77±14.86^b	22.25	0
7 d组	8	354.03±16.7^3a	250.98±16.62^c	29.38	1
9 d组	8	357.53±15.52	239.80±17.06^d	30.05	5

组别	鼠数	断食前(g)	断食后(g)	体重变化率(%)	死亡数(只)
正常组	4	353.08±17.12	－	0	0
3 d组	8	357.88±18.58^a	306.89±16.29^b	14.29	0
5 d组	8	355.30±15.90^a	276.77±14.86^b	22.25	0
7 d组	8	354.03±16.7^3a	250.98±16.62^c	29.38	1
9 d组	8	357.53±15.52	239.80±17.06^d	30.05	5

组别	鼠数	脑组织含水量(g)	变化率(%)	死亡数(只)
正常组	4	81.271.26	－	0
3 d组	8	82.371.18	1.34	0
5 d组	8	84.611.83^a	3.95	0
7 d组	8	79.050.03^a	2.73	1
9 d组	8	77.930.01^a	4.11	5

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