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ISSN 2095-9133
CN 11-9361/R
CODEN XNKIAC
Started in 1958
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   中华卫生应急电子杂志
   18 April 2025, Volume 11 Issue 02 Previous Issue   
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Explanations of Guidelines
Interpretation of the 2025 Clinical Practice Guidelines for Emergency Management of Vascular Trauma by the European Society of Vascular Surgery
Shujian Jia, Yongqi Li, Sunyu Chen, Zhongzhi Jia
中华卫生应急电子杂志. 2025, (02):  65-72.  DOI: 10.3877/cma.j.issn.2095-9133.2025.02.001
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Original Articles
Characteristics of periostein,tendinin-C and sST2 levels and their effects on acute asthma attack in asthmatic children infected with mycoplasma pneumoniae
Qifei Zhu, Shasha Zhang
中华卫生应急电子杂志. 2025, (02):  73-80.  DOI: 10.3877/cma.j.issn.2095-9133.2025.02.002
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Objective

To study the characteristics of periostin, tenascin-C (TNC), and soluble human matrix metalloproteinase-2 (sST2) levels in asthmatic children infected with Mycoplasma pneumoniae and their impact on acute asthma exacerbations.

Methods

A total of 187 asthmatic children with mycoplasma pneumoniae infection who were hospitalized and treated in our hospital from May 2020 to October 2022 were selected, including 104 males and 83 females, with ages ranging from 10 to 14 years and a mean age of(12.07±1.25) years. The children were categorized into two groups: a remission group (n=134) and an acute exacerbation group (n=53), based on the presence of acute asthma exacerbation. A comparison was made between the two groups in terms of general clinical characteristics, as well as serum levels of periostin, TNC,and sST2. Univariate and multivariate logistic regression analyses were conducted to ascertain whether serum periostin, TNC, and sST2 levels could independently predict the risk of acute exacerbations in children with asthma infected by Mycoplasma pneumoniae. Through the use of receiver operating characteristic (ROC)curves, cutoff values for serum periostin, TNC, and sST2 were identified. Based on the results of multivariate logistic regression analysis, a risk prediction nomogram model incorporating serum periostin, TNC, and sST2 was constructed. The model degree of fitting was evaluated using Hosmer-Lemeshow test and calibration curves, the predictive performance was assessed through ROC curve analysis, and the clinical application value was evaluated using decision curve analysis (DCA).

Results

Compared to the remission group, the acute exacerbation group had a lower proportion of regular use of inhaled corticosteroids (ICS), a lower forced expiratory volume in one second/forced vital capacity ratio (FEV1/FVC),and forced expiratory volume in 1 second as a percentage of predicted value (FEV1/pred), and higher levels of serum periostin, TNC, and sST2(P<0.05). ROC analysis indicated that the AUC values for serum periostin, TNC, and sST2 in predicting acute exacerbations in children with asthma infected by Mycoplasma pneumoniae were 0.673, 0.737, and 0.720, respectively. Multivariate logistic regression analysis indicated that high periostin [OR (95%CI)=1.031 (1.014~1.049)], high TNC [OR (95%CI)=1.099 (1.055~1.144)], and high sST2 [OR (95%CI)=1.171(1.080~1.271)] were all independent risk factors for acute exacerbations in children with asthma infected by Mycoplasma pneumoniae (P<0.05). The nomogram model constructed based on the aforementioned three indicators demonstrated favorable degree of fitting (Hosmer-Lemeshow test: χ2=7.356, df=8, P=0.499). ROC analysis revealed that the AUC value of this nomogram model for predicting acute exacerbations in pediatric patients was 0.838 (95% CI: 0.779~0.898, P<0.001). DCA analysis indicated that this nomogram prediction model exhibited satisfactory clinical net benefit across a threshold probability range of 0~0.95.

Conclusion

The levels of serum periostin, TNC, and sST2 in children with asthma complicated by Mycoplasma pneumoniae infection are strongly correlated with the likelihood of experiencing acute asthma exacerbations.Utilizing a model that incorporates these serum biomarkers can greatly assist healthcare providers in assessing the risk of acute asthma exacerbations in this specific group of children, thereby demonstrating significant clinical utility.

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Factors associated with interruption of chest compression during manual-mechanical conversion of pre-hospital cardiopulmonary resuscitation
Jing Ren, Nan Zhang, Yan Zhu
中华卫生应急电子杂志. 2025, (02):  81-85.  DOI: 10.3877/cma.j.issn.2095-9133.2025.02.003
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Objective

To analyze the related factors of the pause duration caused by the manualmechanical conversion of cardiopulmonary resuscitation (CPR) in out-of-hospital cardiac arrest (OHCA)patients.

Methods

A retrospective cohort study was conducted to analyze the OHCA patients treated by the direct-affiliated emergency stations of Yixing Emergency Medical Center from June 2023 to January 2024, all of whom received mechanical chest compression outside the hospital. A total of 160 OHCA patients were enrolled, including 120 males (75.0%) and 40 females (25.0%), aged 34 to 89 years, with an average age of (62.75±15.48) years. Basic patient information, rescue data, and data related to the pause duration caused by the conversion to mechanical compression were collected.

Results

The patient's weight (r=0.238, P=0.002), body mass index (r=0.238, P=0.002), and the duration of mechanical compression initiation(r=0.912, P<0.001) were positively linearly correlated with the pause duration. Multiple linear regression analysis revealed that the patient's height (P=0.01), body mass index (BMI) (P=0.046), and the duration of mechanical compression initiation (P<0.001) were independent risk factors for the pause duration.

Conclusion

The patient's height, BMI, and the duration of mechanical compression initiation are correlated with the duration of chest compression interruption.

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Machine learning and omics-driven dissection of mitophagy and ferroptosis in sepsis-associated ARDS: unraveling key genetic roles and immune regulatory mechanisms
Fanyan Ou, Qian Guo, Lixiong Zeng, Qiuli Chen, Houyu Gan, Jie Yang
中华卫生应急电子杂志. 2025, (02):  86-101.  DOI: 10.3877/cma.j.issn.2095-9133.2025.02.004
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Objective

To explore the roles and immune regulatory mechanisms of key genes in mitophagy and ferroptosis in sepsis-induced acute respiratory distress syndrome (ARDS) using an integrative analysis of machine learning and transcriptomics.

Methods

The DEGs from the GSE32707 dataset in the GEO database were obtained and the differential genes screened. The core genes were identified and validated by secondary screening of DEGs with LASSO regression and the SVM-RFE algorithm, and their diagnostic performance with ROC curves was evaluated. DEGs-related biological pathways and immune cell interactions were investigated via GSEA and immune infiltration analysis. The hub genes by intersecting mitophagy-related genes, ferroptosis markers, and core DEGs were determined. A multi-dimensional regulatory network was established by predicting miRNA targets (using miRWalk, etc.) and ubiquitination interactions (using UbiBrowser), and then potential regulatory mechanisms of hub genes were explored.

Results

Initially, 576 DEGs were screened. Then, 12 core genes were identified via machine learning algorithms. GSEA and immune infiltration analysis showed these core genes were significantly enriched in immune-related pathways. By integrating mitophagy and ferroptosis-related genes with core DEGs, FTH1 was identified as a hub gene, whose expression positively correlated with neutrophil levels and CCR. Mechanistic exploration suggested FTH1 expression might be regulated by miR-224-5p and interact with the E3 ubiquitin ligase SMURF1, implying its potential involvement in disease progression via ubiquitination modification.

Conclusion

This study, combining machine learning and multi-omics integration, first identifies FTH1 as a key regulator of mitophagy and ferroptosis in sepsis-related ARDS. It reveals a regulatory network where FTH1 might be targeted by miR-224-5p and interact with SMURF1, offering new directions and a theoretical basis for developing early immunointervention targets for this disease.

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Reviews
Research progress on mitochondrial autophagy and autophagy damage in acute pancreatitis
Weixin Chen, Niannian Wang, Hui Yong, Botian Ouyang, Zongyuan Liu, Xiaoguang Lu, Rongxia Li, Xin Kang
中华卫生应急电子杂志. 2025, (02):  102-107.  DOI: 10.3877/cma.j.issn.2095-9133.2025.02.005
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Causes and coping strategies of flight fatigue among helicopter pilots
Daiqi Chen, Jing Yu, Guochang Liu, Suiyan li, Jun Yan
中华卫生应急电子杂志. 2025, (02):  108-110.  DOI: 10.3877/cma.j.issn.2095-9133.2025.02.006
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Characteristics and current status of helicopter emergency medical rescue and the path of relevant system construction in China
Guochang Liu, Jing Yu, Yu Xia, Daiqi Chen, Lu Kang, Jun Yan
中华卫生应急电子杂志. 2025, (02):  111-115.  DOI: 10.3877/cma.j.issn.2095-9133.2025.02.007
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New Technology and Equipments
Design and application of a new simulated blood flow pulsation assisted driving device for ECMO equipment
Bin Chen, Jianfeng Zhang, Yanqing Liu, Dongping Deng, Zi Lin, Chuanlong Li, Wenbing Jiang
中华卫生应急电子杂志. 2025, (02):  116-120.  DOI: 10.3877/cma.j.issn.2095-9133.2025.02.008
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Development and application of a new type of replaceable endotracheal tube
Yujiao Wang
中华卫生应急电子杂志. 2025, (02):  121-123.  DOI: 10.3877/cma.j.issn.2095-9133.2025.02.009
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Case Reports
Quetiapine poisoning complicated with acute respiratory distress syndrome and rhabdomyolysis:report of one case
Chen Wang, Xiangxing Zhang, Mengdi Shi, Xiangdong Guan
中华卫生应急电子杂志. 2025, (02):  124-125.  DOI: 10.3877/cma.j.issn.2095-9133.2025.02.010
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Sabre resuscitation device combined with lower limb squeezing ultra long cardiopulmonary resuscitation for 110 minutes: report of one case
Liuyun Wang, Xiang Li, Qiuying Zhang, Tonghao Zhou
中华卫生应急电子杂志. 2025, (02):  126-127.  DOI: 10.3877/cma.j.issn.2095-9133.2025.02.011
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Video
Construction and reflection on emergency wound center: practice and case sharing of emergency treatmentfor acute and chronic wounds
Zhe Deng
中华卫生应急电子杂志. 2025, (02):  128-128.  DOI: 10.3877/cma.j.issn.2095-9133.2025.02.012
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