To analyze the influence factors of elevated troponin I (cTnI) in patients with acute non-traumatic cerebral hemorrhage.

A total of 138 patients with acute non-traumatic intracerebral hemorrhage admitted to The First People’s Hospital of Chun'an County from April 2022 to April 2024 were enrolled as study subjects, including 76 males and 62 females. The patients were aged 50 to 70 years, with a mean age of (58.99±5.98) years. According to the serum level of cardiac troponin I (cTnI), the patients were divided into two groups: the elevated cTnI group (cTnI≥0.04 ng/mL, n=44) and the normal cTnI group (cTnI<0.04 ng/mL, n=94). Compared with the general data of the two groups, multivariate logistic regression model was used to analyze the influencing factors of cTnI, and restricted cubic spline was used to evaluate the relationship between cTnI and prognosis.

Glasgow coma score and the estimated glomerular filtration rate (eGFR) were lower at admission in the elevated group (GCS), as compared to the normal group, The hematoma volume and hemorrhage involvement in the insula area were higher than those in the normal group (P<0.05); Multivariate logistic regression analysis showed that the risk of elevated cTnI level in patients with acute non-traumatic intracerebral hemorrhage was associated with high eGFR (OR=0.977,95% CI: 0.956~0.997), high GCS score (OR=0.272, 95% CI: 0.160~0.462), bleeding involvement of island region (OR=3.948, 95% CI: 1.139~13.679), and hematoma volume (OR=1.145, 95% CI: 1.045~1.254) (all P<0.05); Of the 138 patients, In 37 patients, the mRS scores from 4 to 6 were classified as poor prognosis. Taking the prognosis as the dependent variable, the restrictive cubic spline plot showed that with the increasing levels of cTnI, the greater the risk of having a poor prognosis was noted, with non-linear dose-response relationship between cTnI and prognosis (P<0.05).

Elevated cTnI is associated with eGFR, GCS score, hemorrhage involvement of the insula region, and hematoma volume, and cTnI levels showed a non-linear dose-response relationship with outcome in patients with acute non-traumatic ICH.

To investigate the correlation between blood pressure circadian rhythm and early neurological deterioration (END) in patients with acute small artery occlusive (SAO) cerebral infarction.

A total of 116 patients with cerebral infarction admitted to the Department of Neurology, Wujin Hospital Affiliated to Jiangsu University from January 2023 to October 2023 were enrolled as research subjects, including 79 males and 37 females, aged 48 to 87 years with a mean age of (67.83±11.12) years. Twenty-four-hour ambulatory blood pressure monitoring (ABPM) was performed on all 116 patients with acute SAO cerebral infarction. According to the monitoring results, the blood pressure circadian rhythm was divided into three types: dipper, non-dipper and reverse dipper. Compare whether there is a statistically significant difference in the proportion of patients developing END among the three groups, and whether the alteration of blood pressure circadian rhythm was an independent risk factor for END was analyzed.

ABPM showed that there were 23 cases in the dipper group, 52 cases in the non-dipper group and 41 cases in the reverse dipper group among the subjects. The numbers of patients who developed END in the three groups were 3, 7 and 14, respectively. There was a statistically significant difference in the incidence of END among the three groups (P<0.05). Further study revealed that the alteration of blood pressure circadian rhythm was an independent risk factor for END (P<0.05).

The alteration of blood pressure circadian rhythm is commonly found in patients with acute SAO cerebral infarction, among which the reverse dipper type is the most prevalent. Moreover, the alteration of blood pressure circadian rhythm is an independent risk factor for END.

To study the application of sequential treatment with high-flow oxygen therapy and noninvasive positive pressure ventilation in the treatment of elderly patients with chronic obstructive pulmonary disease (COPD) complicated with type Ⅱ respiratory failure.

A retrospective analysis was performed on the medical records of 84 elderly patients with COPD complicated with type Ⅱ respiratory failure admitted to Nanjing Drum Tower Hospital GroupSuqian Hospital from 2022 to 2024, including 40 males and 44 females. The patients were aged 60 to 73 years, with a mean age of (62.78 ± 6.83) years. According to the ventilation method, they were divided into three groups: ventilation group, oxygen therapy group, and combination group, with 28 cases in each group. The ventilation group received non-invasive positive pressure ventilation, the oxygen therapy group received high flow oxygen therapy, and the combination group received sequential non-invasive positive pressure ventilation with high flow oxygen therapy. Forty-eight hours after treatment, the clinical efficacy and the success rate of weaning from the ventilator were compared among the three groups; After 12 hours, 24 hours, 48 hours and 72 hours of treatment, the oxygenation index and respiratory rate were compared among the three groups.

At 12, 24, 48, and 72 hours after treatment, the oxygenation index of the combination group was higher than that of the oxygen therapy group and the ventilation group, and the oxygen therapy group was higher than the ventilation group, with statistical significance (P<0.05). Before intervention, there was no statistically significant difference in respiratory rate indicators among the three groups (P>0.05). After intervention, the respiratory rate of the combination group was lower than that of the oxygen therapy group and the ventilation group, and the oxygen therapy group was lower than the ventilation group, with statistical significance (P<0.05). 48 hours after treatment, the success rate of weaning in the oxygen therapy group was 85.71% (24/28), the success rate of weaning in the combination group was 92.86% (26/28), and the weaning rate in the ventilation group was 64.29% (18/28). There was no statistically significant difference between the combination group and the oxygen therapy group, or between the oxygen therapy group and the ventilation group (P>0.05), but there was a statistically significant difference between the combination group and the ventilation group (P<0.05).

High-flow oxygen therapy is superior to noninvasive positive pressure ventilation treatment, but the sequential treatment with high-flow oxygen therapy and noninvasive positive pressure ventilation has more advantages in improving the oxygenation index, respiratory rate and the success rate of weaning from the ventilator.

To analyze and study the application effect of predictive nursing strategy and emotional nursing in patients with sudden deafness and tinnitus.

A total of 100 patients with sudden deafness and tinnitus admitted to our hospital from September, 2023 to August, 2024 were selected as the research object of this project. There were 44 males and 56 females. The age ranged from 23 to 69 years, with an average of (44.10±5.18) years.100 patients were randomly divided into observation group (n=50) and control group (n=50). Patients in the control group were intervened by conventional nursing mode during hospitalization, while patients in the observation group were intervened by predictive nursing strategy and emotional nursing mode of traditional Chinese medicine during hospitalization for 2 weeks. The symptom recovery effect, air conduction hearing threshold and tinnitus symptom score before and after nursing and psychological state of the two groups were compared.

The total effective rate of symptom recovery in the observation group was significantly higher than that in the control group (P<0.05). The threshold of hearing guidance and tinnitus symptom score in both groups showed a significant downward trend with the extension of nursing time (F_time of air-guided hearing threshold was 89.62, F_time of THI score was 95.47, F_time>F_0.05 (3.04), P<0.05). There was a significant interaction effect between grouping and nursing time (air conduction threshold F_interaction was 12.35, THI score F_interaction is 14.82, F_interaction>F_0.05 (3.04), P<0.05), which indicated that the decline of the threshold of air conduction hearing and tinnitus symptom score in the observation group was significantly superior. After two weeks of nursing, the scores of Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) in the two groups were lower than those before nursing, and the scores in the observation group were lower than those in the control group at the same period (P<0.05). The recurrence rate of deafness or tinnitus in the observation group was significantly lower than that in the control group (P<0.05).

Predictive nursing and emotional nursing of traditional Chinese medicine can significantly improve the hearing recovery effect of patients with sudden deafness and tinnitus, and play a significant role in reducing the degree of tinnitus and in improving the hearing level and psychological state of patients.

To compare the efficacy and prognosis of recombinant tissue plasminogen activator (rt-PA) and Recombinant Human Tissue-Type Plasminogen Activator (TNK) for the treatment of acute cerebral infarction (AIS).

A retrospective analysis was conducted on the medical records of 103 patients with AIS who were admitted to Yangzhong People's Hospital in Jiangsu Province from January 2024 to December 2024, among them, 65 were male and 38 were female; the age ranged from 42 to 85 years, with an average of (68.19±5.78) years, and they were divided into rt-PA group (51 cases) and TNK group (52 cases) According to different treatment methods. The time from admission to thrombolysis completion, clinical efficacy, National Institutes of Health Stroke Scale (NIHSS) score, complications, modified Rankin Scale (mRS) score and the good prognosis rate at 90 days were compared between the two patient groups.

The time from admission to thrombolysis completion in the TNK group was shorter than that in the rt-PA group (P<0.05). The total effective rate of the TNK group was higher than that of the rt-PA group (P<0.05). The NIHSS scores of both patient groups decreased 24 hours after thrombolysis and 14 days after treatment, and the TNK group was lower than the rt-PA group (P<0.05). The coagulation function indicators of both patient groups increased 24 hours after thrombolysis, but the TNKgroup was lower than the rt-PA group (P<0.05). There was no difference in the total incidence of complications between the two patient groups (P>0.05). The mRS Scores of both groups 1 day before discharge and 90 days after thrombolysis were lower than those before thrombolysis, but there was no difference between the groups (P>0.05), and there was no difference in the good prognosis rate between the two patient groups (P>0.05).

rt-PA and TNK are both effective drugs for AIS thrombolysis under emergency green channel, with similar prognoses, but TNK has advantages in convenient administration and improving short-term efficacy, and clinical selection should be flexible.

To explore the clinical application value of continuous blood purification (CBP) combined with hemoperfusion (HP) in patients with severe sepsis complicated with acute respiratory distress syndrome (ARDS).

The data of 160 patients with severe sepsis complicated with ARDS admitted to the Affiliated Hospital of Shanxi University of Traditional Chinese Medicine from August 2022 to August 2024 were retrospectively selected, including 93 males and 67 females. The age ranged from 41 to 82 years with an average of (63.22±3.58) years. Based on the differences in treatment methods, the patients were divided into two groups: a control group (80 cases) and an observation group (80 cases), who received different treatment plans including conventional treatment and CBP+HP; The hemodynamic indicators, inflammatory factor levels, biochemical indicators, blood gas indicators, prognostic outcomes, and the effects on inflammatory factors [procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6)] were compared between the two groups.

After treatment, the heart rate of the two groups was lower than that of the control group (P<0.05), and the average arterial pressure of the two patient groups was higher than that of the control group (P<0.05); After treatment, both groups showed a decrease in IL-6, hs-CRP, and PCT, with the observation group showing a more significant decrease (P<0.05); After treatment, the arterial oxygen partial pressure (PaO₂) and oxygenation index (PaO₂/FiO₂) increased in both groups, especially in the observation group (P<0.05). After treatment, the levels of serum creatinine (SCr), lactate dehydrogenase (LDH) and serum lactic acid (LAC) in both groups showed a downward trend, and the decrease in the observation group was even greater (P<0.05). After treatment, the scores of acute physiology and chronic health status score system Ⅱ (APACHE Ⅱ) in both groups decreased, especially in the observation group (P<0.05).

The combined implementation of CBP and HP techniques in the treatment of severe sepsis complicated with ARDS not only regulates hemodynamics and reduces inflammatory factors, but also improves blood gas indicators and enhances patient prognosis.

To explore effects of nasal high flow oxygen therapy (HFNC) combined with high-pressure non-invasive positive pressure ventilation (NPPV) on inflammatory factors and lung function in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and type II respiratory failure.

A retrospective analysis was conducted on the treatment of 90 patients with AECOPD combined with type II respiratory failure admitted to the Respiratory Department of Yixing Sixth People's Hospital from January 2022 to January 2025, among them, there were 47 males and 43 females; their ages ranged from 24 to 69 years, with an average of (46.82±7.61) years. The patients were divided into a control group and an observation group, with 45 patients in each group. The control group received high-pressure NPPV treatment, while the observation group received HFNC combined with high-pressure NPPV treatment. Comparative analysis of inflammatory factors [(C-reactive protein, CRP), (interleukin-17, IL-17), (tumor necrosis factor-α, TNF-α)], pulmonary function indicators [(forced vital capacity, FVC), (forced expiratory volume in the first second, FEV1), FEV1/FVC], and blood gas analysis indicators [(partial pressure of oxygen, PaO₂), (partial pressure of carbon dioxide, PaCO₂), pH] between two groups of patients upon admission and 3 days after treatment. The changes of CO₂ and blood pH levels between the two groups, including length of hospital stay, intubation rate, readmission rate after 28 days of follow-up, and treatment efficacy were compared.

At admission, there was no significant difference in the levels of inflammatory factors CRP, IL-17, and TNF-α between the two groups (P>0.05); after 3 days of treatment, the CRP, IL-17, and TNF-α decreased in both groups of patients, the inflammatory factors CRP, IL-17, and TNF-α in the observation group were lower than those in the control group (P<0.05). At admission, there was no significant difference in the lung function indicators FVC, FEV1, and FEV1/FVC between the two groups (P>0.05); after 3 days of treatment, the FVC, FEV1, and FEV1/FVC of both groups of patients increased,and the lung function indicators FVC, FEV1, and FEV1/FVC in the observation group were higher than those in the control group (P<0.05). At admission, there was no significant difference in the blood gas analysis indicators PaO₂, PaCO₂, and pH value between the two groups (P>0.05); after 3 days of treatment, the PaO₂ and pH values of both groups of patients increased significantly, while the PaCO₂ values decreased significantly,the blood gas analysis indicators PaO₂ and pH value in the observation group were higher than those in the control group, while PaCO₂ was lower than that in the control group (P<0.05). The observation group had lower hospitalization days, intubation rate, and readmission rate due to the disease after 28 days of follow-up compared to the control group (P<0.05). The total effective rate of clinical treatment in the observation group was higher than that in the control group (P<0.05).

The combination of HFNC and high-pressure NPPV in the treatment of AECOPD patients with type II respiratory failure can effectively improve lung function indicators, blood gas analysis indicators, reduce inflammatory reactions, and has good therapeutic effects, which is worth promoting.

To investigate the current status of pre-hospital emergency care and analyze the epidemiological characteristics of patients aged 80 years and older in Beijing in 2024.

All data on emergency dispatches for the oldest-old patients were collected from the medical emergency office management system of the Beijing Emergency Medical Center in 2024 and analyzed using descriptive epidemiological methods.

A total of 147,247 prehospital emergency cases involving the oldest-old patients were included in this study. Female patients outnumbered male patients (1.3∶1). The number of cases in urban areas was higher than in suburban areas, with an urban-to-suburban ratio of 1.7∶1. Chaoyang District had the highest number of cases, accounting for 19.83% of the total. Circulatory system diseases were the most common reason for prehospital emergency calls, representing 28.10% of cases, followed by injury-related diseases, accounting for 16.97%. The month with the highest number of prehospital emergency cases was December, accounting for 9.45%, while June had the lowest, at 7.61%. The peak time for emergency calls was between 08:00 and 10:00, accounting for 16.35% of cases, followed by 12:00-14:00, at 11.39%. The period with the fewest calls was between 02:00 and 04:00, accounting for 3.19%.

Beijing has entered a stage of moderate population aging. It is essential to address the challenges of an aging population, implement real-time health management, and optimize the allocation of prehospital emergency resources based on regional, seasonal, monthly, and daily peak-time distributions. Daily professional training should focus on the on-site management of emergencies such as circulatory system diseases and injury-related conditions to enhance the capacity and quality of prehospital emergency care.

To explore the clinical effect of radiofrequency ablation on knee joint pain and function improvement in patients with rheumatoid arthritis.

A total of 68 patients (19 males, 49 females) with knee pain secondary to rheumatoid arthritis (mean age, 54.3±10.3 years; range, 30~78 years) were consecutively enrolled from March to November 2023 at the Affiliated Hospital of Jiangsu University. Patients were randomized using a random number table into a control group (n=34) receiving oral analgesic medication and the RFA group (n=34) undergoing genicular nerve radiofrequency ablation. All patients continued to receive standardized background antirheumatic therapy. Pain intensity and knee function were assessed using the Numerical Rating Scale (NRS) and the Lysholm Knee Scoring Scale, respectively. Outcomes were evaluated before treatment and after the intervention, followed by between-group comparisons. Clinical efficacy was further assessed. Serum rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) antibody levels were measured at baseline and at 6 months post-treatment.

All participants completed the 6-month follow-up. No statistically significant differences were observed in baseline characteristics or outcome measures between the two groups (P>0.05). Post-treatment assessments revealed significant within-group improvements in NRS and Lysholm scores (P<0.05). Between-group comparisons demonstrated that the RFA group exhibited significantly greater reductions in pain scores, more pronounced improvements in knee function, and higher clinical efficacy than the control group (P<0.05). RF and CCP levels did not differ significantly either between groups or within groups when comparing baseline with 6-month post-treatment values.

Genicular nerve radiofrequency ablation confers superior analgesic and functional benefits compared with oral analgesic therapy in patients with rheumatoid arthritis-related knee pain, without exerting measurable effects on serologic markers of disease activity.