To investigate the expression characteristics and clinical significance of serum sPD-1/L1 and interferon-γ expression in patients with acute coronary syndrome.

This study retrospectively included 73 patients admitted to the emergency department of Beijing Electric Power Hospital from November 2020 to October 2022. All patients were divided into a control group and a coronary heart disease group (divided into chronic coronary disease group and acute coronary syndrome group). 32 patients in the acute coronary syndrome group, including 19 males and 13 females; Age range from 54 to 84 years old, with an average of (69.09±14.97) years old. There are 21 patients in the chronic coronary disease group, including 8 males and 13 females; Age range from 65 to 83 years old, with an average of (74.24±8.60) years old. 20 cases in the control group, including 13 males and 7 females; Age range from 58 to 73 years old, with an average of (65.70±7.39) years old. Enzyme linked immunosorbent assay (ELISA) was used to detect serum sPD-1, sPD-L1, and IFN in three groups of patients- γ Horizontal.

The comparative analysis of serum immune markers among the three groups showed that there were significant differences in the levels of IL-18, IFN-γThe comparative analysis of serum immune markers among the three groups showed that there were sigisease group were significantly higher than those in the control group (P<0.01), and the expression levels of IFN-an those in the control group ( showed that there were significant differences in the levels of IL-18, IFN-ol group (P<0.05). The expression of L1 in the ACS group and the chronic coronary disease group was significantly higher than that in the control group, and the difference was statistically significant (P<0.05). Pearson correlation analysis showed that serum IFN-p was significantly higher thorrelated with sPD-1 (r=0.922, P<0.01) and L1 (r=0.922, P<0.01) in the ACS group.

There is a certain relationship between sPD-1/L1 and IFN-N-p was significantly higher than that in the control group, and the difference was statistically significssion of sPD-1/L1, which may play an important role in the immunoregulation of ACS.

To investigate the correlation between serum cytokines and pneumonia secondary to acute cerebral infarction (ACI) .

99 patients with acute cerebral infarction admitted to the Neurology Intensive Care Unit of Dongfang Hospital Affiliated to Tongji University were selected as the study subjects, including 70 males (70.71%) and 29 females (29.29%); The age range is from 27 to 95 years old, with an average of (67±13) years old. Within 48 hours of onset, serum concentrations of twelve cytokines, including interleukin-1, were detected β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12P70, IL-17A, interferon (IFN)-α, IFN- γ, Tumor necrosis factor (TNF)-α And serum albumin, globulin, peripheral blood leukocyte count, peripheral blood lymphocyte count; According to whether the research subjects developed pneumonia afterwards, they were divided into pneumonia group (44 cases) and non pneumonia group (55 cases). Binary logistic regression analysis was used to determine whether the twelve cytokines were independent predictors of pneumonia after acute cerebral infarction.

Binary logistic regression analysis showed that the increased serum IL-10 (OR 1.24, 95% CI 1.01-1.52, P=0.039) and increased peripheral blood WBC counts (OR 1.50, 95% CI 1.18-1.92, P=0.001) were independent predictors for ACI secondary pneumonia. To predict ACI secondary pneumonia, the sensitivity and specificity of serum IL-10>2.50 ng/L within 48 hours of ACI, were 61.36% and 64.29%; the sensitivity and specificity of peripheral blood WBC counts>10.00×10⁹/L within 48 hours of ACI, were 50.00% and 81.48%; the sensitivity and specificity of the combination of the two were 34.09% and 83.33%, respectively.

At the early stage of ACI, increased serum IL-10 and peripheral blood WBC counts have a certain diagnostic value for ACI secondary pneumonia, with high specificity but low sensitivity.

To study the effect of integrated trauma center on the quality of treatment for patients with severe multiple injuries.

A retrospective case-control study was conducted to analyze the clinical data of 1286 patients with severe multiple injuries admitted to Changzhou Second People's Hospital from January 2016 to December 2022, including 894 males and 392 females; Age range from 16 to 80 years old, with an average of (51.9±15.9) years old. The Injury Severity Scale (ISS) ranges from 16 to 57 points, with an average of (28.0±9.1) points. 735 patients treated after the stable operation of our integrated trauma center were selected as the observation group, while 551 patients treated before and during the establishment of the integrated trauma center were selected as the control group. Compare the differences in trauma treatment quality between two groups of patients.

The quality control index of trauma treatment in the observation group was obviously better than that in the control group.

The integrated trauma center can effectively improve the quality of treatment of severe trauma patients and improve the success rate of treatment, which is worthy of further promotion.

To investigate the antagonistic effect of quercetin on bone marrow-derived foam cell pyroptosis, and to study the anti-atherosclerosis effect and mechanism of quercetin from the perspective of anti-pyroptosis.

In animal experiments, quercetin gavage atherosclerosis model mice were grouped, and the effect of quercetin on atherosclerotic lesions in mice was detected by oil red O staining, and the expression of pyroptosis-related proteins in atherosclerotic tissues was also detected by Western blotting. In cell experiments, primary mouse bone marrow-derived macrophages (BMDMs) were cultured, ox-LDL was used to induce the formation of foam cells, cell viability assay to detect the optimal concentration of quercetin on mouse bone marrow-derived foam cells, enzyme-linked immunosorbent assay (ELISA) to detect the amount of lactate dehydrogenase (LDH) in the medium, flow cytometry to detect the amount of reactive oxygen species (ROS) in cells, and the expression of pyroptosis-related protein in mouse bone marrow-derived foam cells was detected by Western blotting.

After high-concentration quercetin intervention, the atherosclerosis of the arterial sinus stained with oil red O was reduced, the pyroptosis-related protein and the amount of nitric oxide (NO) in atherosclerotic lesions were down-regulated. The amount of LDH in the medium decreased after quercetin was applied to mouse bone marrow-derived foam cells, and Western blotting showed that pyroptosis-related proteins were down-regulated.

Quercetin may down-regulate the expression of NLRP3 by inhibiting ROS production, thereby inhibiting pyroptosis of foam cells and improving atherosclerosis.

To sort out the relevant concepts of smart emergency response and put forward an understanding of the connotation of it by using the bibliometric tools to visually analyze the research hotspots and development trends in the field for further studies.

Literature analysis was used to understand the relevant connotation of smart emergency response. Citespace bibliometric analysis was carried out to visualize the articles in the field of smart emergency response from 2003 to 2023.

Emergency management research direction turned to the application of technical means to build the intelligent and digital emergency management model and gradually changed the management mode of "pay more attention to disposal than to prevention", and it also showed a trend of "moving forward the gateway". "Artificial intelligence", "internet of things", "digital twin", "smart emergency response" and "resilient cities" might become the research hotspots and development trends in the future.

Chinese scholars should continue to focus on the key research areas of emergency management, to explore the scientific issues behind the practical problems of intelligent emergency management and to carry out in-depth studies, such as strengthening the measurement of practical processes and effects, and developing scientific evaluation tools. Moreover, with the practical development of intelligent emergency management, new challenges have been put forward for us. Therefore, our research ability and knowledge structure should be enhanced.

To develop evaluation criteria for the maturity of human resource management (HRM) capabilities of emergency medical rescue teams in various dimensions and to conduct empirical testing on the evaluation model, providing a quantitative evaluation tool for managers to identify gaps in HRM capabilities and guide decision-making.

The evaluation model had the function of showing the difference and witnessing achievements. This model was used to quantitatively evaluate the human resource management capability of emergency medical rescue teams in a tertiary public hospital in Tianjin to determine the maturity level. Using the quadrant analysis method we further analyzed the dimensions and factors of human resource management ability, and put forward targeted improvement strategies.

The total score of the team was 53.16, classified as "defined level". The evaluation results reflected that the team’s HRM practice had been gradually standardized, the maturity level of five dimensions was balanced, and each dimension had advantages and needed to be improved.

Based on the empirical results, it is suggested to establish the mechanism of co-construction and co-management of emergency medical rescue teams, and to set up a human resource management practice system to provide strong guarantee for human resource management of emergency medical rescue team.