Change in triglyceride-glucose index in patients with acute myocardial infarction and its clinical value

doi:10.3877/cma.j.issn.2095-9133.2025.05.007

Abstract

Abstract:

Objective

To investigate the changes in the triglyceride-glucose (TyG) index and its clinical value in patients with premature acute myocardial infarction (AMI).

Methods

A retrospective analysis was conducted on 110 patients with premature AMI who were hospitalized and definitively diagnosed in the Department of Cardiology at Changzhou Wujin People's Hospital from January 2021 to December 2022. Patients ranged in age from 22 to 64 years (average 47.60±8.35 years). Of these, 88 (80.00%) were male and 22 (20.00%) were female. For comparison, patients hospitalized during the same period were selected as controls. These control patients lacked typical angina symptoms, showed stenosis of <50% in major coronary vessels (≥2.0 mm) on coronary angiography, and had an age of onset of <55 years for males or <65 years for females. Ages ranged from 29 to 64 years (mean 53.33±6.65). Of these, 80 were men (33.76%) and 157 were women (66.24%). The TyG index was compared between the two groups, and subgroup analysis was performed by gender. Logistic regression analysis was used to explore the association between the TyG index and premature AMI, and receiver operating characteristic (ROC) curve analysis was employed to evaluate the diagnostic value of the TyG index for premature AMI.

Results

Patients in the premature AMI group had significantly lower age and HDL-C levels than the control group, while exhibiting significantly higher proportions of males, fasting blood glucose, LDL-C, and HbA1c levels. The TyG index was significantly higher in the premature AMI group compared to the control group (10.53±0.78 vs. 10.20±0.55, P<0.001). Subgroup analysis by sex revealed that the TyG index remained significantly higher in the premature AMI group for both male and female subgroups. Logistic regression results indicated that the TyG index was an independent influencing factor for premature AMI (OR=1.664, 95% CI=1.102-2.513, P=0.015). The area under the ROC curve for the TyG index in diagnosing premature AMI was 0.634 (95% CI: 0.570-0.698, P<0.001), with a sensitivity of 0.545 and specificity of 0.692.

Conclusion

The TyG index is significantly elevated in patients with premature AMI and is an independent correlated factor for premature AMI.

Key words: Triglyceride-glucose index, Premature acute myocardial infarction, Coronary artery disease

Jiangwei Cao, Lamei Li, Xiaoxia Li, Yan Liu, Fei Gu. Change in triglyceride-glucose index in patients with acute myocardial infarction and its clinical value[J]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2025, 11(05): 289-293.

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References 18

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项目	例数	年龄（岁）	男性[例（%）]	BMI（kg/m²）	吸烟[例（%）]	高血压史[例（%）]	收缩压（mmHg）	舒张压（mmHg）	肌酐（µmol/L）
早发AMI组	110	47.60±8.35	88（80.00）	25.81±3.63	71（64.55）	58（52.73）	133.91±22.47	85.35±15.18	70.59±16.48
对照组	237	53.33±6.65	80（33.76）	25.31±3.68	39（16.46）	94（39.66）	131.83±16.37	82.96±11.91	66.31±32.69
t/Z/x²值		6.87	64.33	1.18	80.25	5.21	0.97	1.59	1.30
P值		<0.001	<0.001	>0.05	<0.001	<0.05	>0.05	>0.05	>0.05
项目	例数	尿酸（µmol/L）	FBG（mmol/L）	TC（mmol/L）	TG（mmol/L）	HDL-C（mmol/L）	LDL-C（mmol/L）	HbA1c（mmol/L）
早发AMI组	110	369.77±108.97	6.58±2.66	4.82±1.59	1.82（1.23~2.53）	1.25±0.30	2.95±1.02	6.21±1.16
对照组	237	347.89±115.91	5.10±0.85	4.64±1.05	1.57（1.12~2.31）	1.37±0.38	2.73±0.76	5.90±0.70
t/Z/x²值		1.67	4.92	1.30	1.80	3.02	2.22	3.00
P值		>0.05	<0.001	>0.05	>0.05	<0.05	<0.05	<0.05

项目	例数	年龄（岁）	男性[例（%）]	BMI（kg/m²）	吸烟[例（%）]	高血压史[例（%）]	收缩压（mmHg）	舒张压（mmHg）	肌酐（µmol/L）
早发AMI组	110	47.60±8.35	88（80.00）	25.81±3.63	71（64.55）	58（52.73）	133.91±22.47	85.35±15.18	70.59±16.48
对照组	237	53.33±6.65	80（33.76）	25.31±3.68	39（16.46）	94（39.66）	131.83±16.37	82.96±11.91	66.31±32.69
t/Z/x²值		6.87	64.33	1.18	80.25	5.21	0.97	1.59	1.30
P值		<0.001	<0.001	>0.05	<0.001	<0.05	>0.05	>0.05	>0.05
项目	例数	尿酸（µmol/L）	FBG（mmol/L）	TC（mmol/L）	TG（mmol/L）	HDL-C（mmol/L）	LDL-C（mmol/L）	HbA1c（mmol/L）
早发AMI组	110	369.77±108.97	6.58±2.66	4.82±1.59	1.82（1.23~2.53）	1.25±0.30	2.95±1.02	6.21±1.16
对照组	237	347.89±115.91	5.10±0.85	4.64±1.05	1.57（1.12~2.31）	1.37±0.38	2.73±0.76	5.90±0.70
t/Z/x²值		1.67	4.92	1.30	1.80	3.02	2.22	3.00
P值		>0.05	<0.001	>0.05	>0.05	<0.05	<0.05	<0.05

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