To evaluate the hemodynamic monitoring of thoracic impedance (TEB) in patients with heart failure with preserved ejection fraction (HFpEF) and its clinical significance.

The clinical data of 100 patients admitted to the Second Hospital of Wuxi from 2022 to 2024 were analyzed retrospectively, including 73 males and 27 females. The age ranged from 56 to 72 years with an average of (64.35 7.18) years. According to the left ventricular ejection fraction (LVEF), patients were divided into control group (50 cases) with heart failure with reduced ejection fraction (HFrEF) and study group (50 cases) with HFpEF; at the same time, 50 patients without heart failure were selected as normal group. Three groups of patients were monitored for cardiac output (CO), cardiac index (CI), stroke rate (SV), heart rate index (SI), heart rate variability (HRV), preload [thoracic fluid conductivity (TFC), heart rate variability (SVV), vascular volume (IVV)], afterload [peripheral resistance per beat (SSVR), peripheral resistance index per beat (SSVRI), systemic resistance (SVR), vascular elasticity (VA)], myocardial contractility [left ventricular work per beat (LSW), left ventricular work per beat index (LSWI), pre ejection phase (PEP), left ventricular ejection time (VET)] using thoracic impedance spectroscopy (TEB), LVET, systolic time ratio (STR), ejection systolic index (EPCI), strain state index (ISI), and contractility variability (COPDI).

The LAD, STR, PEP, SSVR, and TFC values of the study group were higher than those of the normal group, while EPCI was lower than that of the normal group (P<0.05); The EPCI, LVET, LSWI, LSW, SI, SV, and CI of the control group were lower than those of the normal group, while LVDD, LAD, STR, PEP, SSVR, IVV, TFC, and HRV were higher than those of the normal group (P<0.05); The LVDD, STR, PEP, and IVV of the study group were all lower than those of the control group, while LVET, LSWI, LSW, SI, and SV were higher than those of the control group (P<0.05). After Pearson correlation analysis, STR, PEP, VA, SVR, SSVRI, SSVR, and TFC were positively correlated with the ratio of peak velocity of early diastolic blood flow (E) at the mitral valve orifice to peak velocity of early diastolic motion of the mitral annulus (e) (E/e) (P<0.05), while EPCI, LVET, LSWI, LSW, IVV, HRV, SI, SV, CI, and CO were negatively correlated with E/e (P<0.05). The ROC curve results showed that the areas under the ROC curves corresponding to STR, PEP, and TFC were 0.774, 0.808, and 0.730, respectively.

TEB hemodynamic monitoring can help to evaluate the diastolic function of the heart, if the values of IVV, LSWI, LSW, SI and SV are in the normal range, and the values of STR, PEP and TFC are rising, it can be used to assist in the diagnosis of HFpEF.

To explore the clinical value of CT enhanced scanning in evaluating volume responsiveness in critically ill patients.

A total of 75 critically ill patients admitted from January 2022 to June 2024 were selected prospectively. Based on changes in cardiac output after volume loading tests, patients were divided into a volume-responsive positive group (n=42) and a negative group (n=33). All patients underwent CT enhanced scanning to measure parameters such as the variability of abdominal aortic cross-sectional area (IVCI), superior vena cava cross-sectional area (IVCV), and pulmonary artery cross-sectional area (PAVI). Simultaneously, bedside ultrasound was used to assess inferior vena cava variability index (IVC-VI) and passive leg raising (PLR) tests. The accuracy of different methods in evaluating volume responsiveness was compared.

IVCI, IVCV, and PAVI were significantly higher in the volume-responsive positive group than in the negative group (P<0.05). Receiver operating characteristic (ROC) curve analysis showed that the areas under the curve (AUC) for IVCI, IVCV, and PAVI in predicting volume responsiveness were 0.87, 0.83, and 0.78, respectively, which were superior to the traditional IVC-VI assessment method (AUC=0.72, P<0.05). The fluid management protocol guided by CT enhanced scanning significantly shortened the duration of mechanical ventilation and ICU stay (P<0.05).

CT enhanced scanning provides high accuracy in evaluating volume responsiveness for critically ill patients, offering a reliable basis for individualized fluid management and improving clinical outcomes.

To analyze the diagnostic value of interleukin-6 (IL-6) and complement 1q (C1q) in acute ulcerative colitis and their correlation with gut microbiota.

A total of 120 patients with ulcerative colitis (UC) admitted to Yulin Traditional Chinese Medicine Hospital from January 2022 to March 2025 were selected as the study group. According to the modified Mayo score, they were divided into an acute phase group (n=62) and a remission phase group (n=58). During the same period, 60 healthy examinees were selected as the control group. By comparison of the changes in serum IL-6, C1q, and gut microbiota among different groups, logistic regression analysis was used to explore the effects of serum IL-6 and C1q on the progression of UC disease. Receiver operating characteristic curves (ROC) were plotted to analyze the diagnostic value of serum IL-6 and C1q for acute ulcerative colitis, and Pearson test was used to analyze the correlation between serum IL-6, C1q, and gut microbiota count.

There were statistically significant differences (P<0.05) in the levels of serum IL-6, C1q, and major gut microbiota (Bifidobacterium, Lactobacillus, Bacteroidetes, Escherichia coli, and Enterococcus) among the three groups. Among them, serum IL-6, Bacteroidetes, Escherichia coli, and Enterococcus gradually increased in the control group, remission group, and acute group (P<0.05); Serum C1q, Bifidobacterium, and Lactobacillus gradually decreased in the control group, remission group, and acute group (P<0.05). According to logistic regression analysis, serum IL-6 and C1q were important factors affecting the staging of UC disease activity (P<0.05). ROC curve analysis showed that serum IL-6 and C1q could predict the progression of UC disease, with the best combined efficacy (P<0.05). The area under the curve (AUC), sensitivity, and specificity were 0.931 (95% CI: 0.854-0.977), 89.4%, and 75.8%, respectively. Pearson correlation analysis showed that serum IL-6 was positively correlated with Bacteroidetes, Escherichia coli, and Enterococcus (P<0.05), and negatively correlated with Bifidobacterium and Lactobacillus (P<0.05); Serum C1q was inversely proportional to Bacteroidetes, Escherichia coli, and Enterococcus (P<0.05), and directly proportional to Bifidobacterium and Lactobacillus.

Serum IL-6 and C1q can predict the occurrence of acute UC, with the former being positively correlated with Bacteroidetes, Escherichia coli, and Enterococcus, and the latter being positively correlated with Bifidobacterium and Lactobacillus.

To explore the application effect of the fast-track nursing model based on multidisciplinary collaboration in the interventional treatment of acute type B aortic dissection.

The clinical data of 80 patients with acute type B aortic dissection admitted to our hospital from May 2023 to April 2025 were retrospectively analyzed. Among them, there were 49 males and 31 females, the age ranged from 44 to 72 years, with an average of (58.84±6.85) years. 38 patients who received the conventional nursing mode from May 2023 to April 2024 were assigned to the control group, and 42 patients who received the multidisciplinary collaborative fast-track nursing mode from May 2024 to April 2025 were assigned to the observation group. The treatment effects between the two groups were compared.

The diagnosis time, examination time, emergency stay time and transfer time of the observation group were all shorter than those of the control group (P<0.05); the success rate of treatment in the observation group was higher than that of the control group (P<0.05); The length of stay in the ICU, the time to get out of bed after surgery, and the length of hospital stay in the observation group were all shorter than those in the control group (P<0.05); the scores of the Herth Hope Scale in the observation group at 7 days after admission and at discharge were higher than those in the control group (P<0.05); there was no statistically significant difference by comparison of the total incidence of complications between the two groups (P>0.05); the total satisfaction rate of the observation group with nursing was higher than that of the control group (P<0.05).

The fast-track nursing model based on multidisciplinary collaboration is helpful to shorten the emergency process of patients undergoing interventional therapy for acute type B aortic dissection and promote the early recovery of patients.

To observe the effect of medical game nursing mode led by specialist nurses in the treatment of severe mycoplasma pneumoniae pneumonia (SMPP) children undergoing fiberbronchoscopy.

Children with SMPP who underwent fiberbronchoscopy in our hospital from January 2023 to May 2024 were prospectively selected as the study objects. According to the simple numerical random table method, they were randomly divided into control group (routine nursing, n=151) and observation group (medical game nursing mode led by specialist nurses, n=151). The time indexes (cough relief, disappearance of pulmonary rale, normal body temperature), biochemical indexes (FVC, FEV1, PEF, SaO₂, PaO₂, PaCO₂), mood (CMFS), comfort level (GCQ), quality of life (PedsQL), treatment compliance were compared between the two groups.

The time of cough relief, lung rales disappearance and normal body temperature in observation group were shorter than those in control group (P<0.05). After nursing, biochemical indexes FVC, FEV1, PEF, SaO₂, PaO₂, GCQ scores and PedsQL scores were higher than before nursing (P<0.05), while biochemical indexes PaCO₂ and CMFS scores were lower than before nursing (P<0.05). After nursing, biochemical indexes FVC, FEV1, PEF, SaO₂, PaO₂, GCQ scores and PedsQL scores in observation group were higher than those in control group (P<0.05), while biochemical indexes PaCO₂ and CMFS scores were lower than those in control group (P<0.05). The rates of compliance in the observation group were 95.36%, higher than those in the control group 84.77% (P<0.05).

The application of the medical game nursing mode led by specialized nurses in the SMPP children undergoing fiberbronchoscopy can improve the compliance of the children, shorten the time index, improve the biochemical index, reduce the fear, and therefore improve the comfort level and quality of life.

To investigate the therapeutic value and safety profile of combined nebulized budesonide and salbutamol for pediatric acute severe asthma exacerbations.

This prospective, randomized and controlled trial enrolled 94 children with acute severe asthma exacerbations treated between January 2020 and December 2024. Patients were randomly assigned to a combination therapy group (n=48, budesonide + salbutamol nebulization)and a monotherapy group (n=46, salbutamol nebulization alone). Comparative assessments included clinical efficacy evaluation, pulmonary function parameters, inflammatory biomarker modulation, symptom resolution rates, medication safety, and subsequent recurrence frequency.

The combination therapy group demonstrated significant advantages, including higher total effective rate (P<0.05), superior pulmonary function recovery, with greater improvements in FEV1, PEF, and FEV1/FVC compared to the monotherapy group (P<0.05), more pronounced reduction in inflammatory markers (IL-6, TNF-α, hs-CRP) (P<0.05), accelerated symptom resolution (wheezing, dyspnea, coughing) and shortened hospitalization duration (P<0.05), comparable adverse reaction rates (P>0.05) and significantly reduced three-month recurrence risk (P<0.05).

For children with acute severe asthma, combined budesonide-salbutamol nebulization speeds symptom relief, aids lung function recovery, reduces airway inflammation, lowers recurrence risk, and it is safe, warranting clinical promotion. This regimen offers integrated benefits and is a valuable clinical option.

To investigate the changes in the triglyceride-glucose (TyG) index and its clinical value in patients with premature acute myocardial infarction (AMI).

A retrospective analysis was conducted on 110 patients with premature AMI who were hospitalized and definitively diagnosed in the Department of Cardiology at Changzhou Wujin People's Hospital from January 2021 to December 2022. Patients ranged in age from 22 to 64 years (average 47.60±8.35 years). Of these, 88 (80.00%) were male and 22 (20.00%) were female. For comparison, patients hospitalized during the same period were selected as controls. These control patients lacked typical angina symptoms, showed stenosis of <50% in major coronary vessels (≥2.0 mm) on coronary angiography, and had an age of onset of <55 years for males or <65 years for females. Ages ranged from 29 to 64 years (mean 53.33±6.65). Of these, 80 were men (33.76%) and 157 were women (66.24%). The TyG index was compared between the two groups, and subgroup analysis was performed by gender. Logistic regression analysis was used to explore the association between the TyG index and premature AMI, and receiver operating characteristic (ROC) curve analysis was employed to evaluate the diagnostic value of the TyG index for premature AMI.

Patients in the premature AMI group had significantly lower age and HDL-C levels than the control group, while exhibiting significantly higher proportions of males, fasting blood glucose, LDL-C, and HbA1c levels. The TyG index was significantly higher in the premature AMI group compared to the control group (10.53±0.78 vs. 10.20±0.55, P<0.001). Subgroup analysis by sex revealed that the TyG index remained significantly higher in the premature AMI group for both male and female subgroups. Logistic regression results indicated that the TyG index was an independent influencing factor for premature AMI (OR=1.664, 95% CI=1.102-2.513, P=0.015). The area under the ROC curve for the TyG index in diagnosing premature AMI was 0.634 (95% CI: 0.570-0.698, P<0.001), with a sensitivity of 0.545 and specificity of 0.692.

The TyG index is significantly elevated in patients with premature AMI and is an independent correlated factor for premature AMI.

To explore the application value of unmanned aerial vehicle (UAV) technology in regional emergency medical rescue.

A total of 400 cases of emergency medical rescue from March 2023 to December 2024 were selected as the research objects and randomly divided into drone rescue group and traditional rescue group, with 200 cases in each group. The delivery time of materials, the time of transporting the wounded and the positioning accuracy were compared between the two groups, and the changes of vital signs in the process of transporting patients between the two groups were analyzed, and the intact rate of medical materials, the success rate of rescue and the success rate of transporting patients between the two groups were counted.

The delivery time of materials in UAV rescue group was shorter than that in control group (P<0.05), the transfer time of wounded was faster than that in control group (P<0.05), and the positioning accuracy was higher than that of the control group (P<0.05). There was no significant difference in heart rate, average arterial pressure and respiratory rate among the vital signs in the unmanned aerial vehicle rescue group during transportation (P>0.05). The heart rate in the vital signs in the control group increased faster during transportation than before (P<0.05). The average arterial pressure decreased and the respiratory rate increased (P<0.05), and the heart rate and respiratory rate of unmanned aerial vehicle rescue group were slower than those of traditional rescue group (P<0.05) and the average arterial pressure was higher than that of traditional rescue group (P<0.05). The intact rate of medical materials, the success rate of rescue and the success rate of patient transport in the UAV rescue group were higher than those in the control group (P<0.05).

The application of UAV technology in regional emergency medical rescue can significantly shorten the rescue time and improve the rescue efficiency, which has broad application prospects and development potential.

To analyze the research hotspots and development trends of the concept of 'ferroptosis’ in the context of sepsis, as well as the cooperation and exchange between countries, authors and institutions.

We used the method of bibliometrics to analyze the keywords, countries and institutions, authors, literature co-citation and other information of ferroptosis research in the field of sepsis from multiple perspectives with the help of CiteSpace, VOSviewer, RStudio, Excel and other software, and showed it in the form of knowledge map.

A total of 324 articles and 1378 keywords were collected in the core collection of Web of Science. The top five countries in terms of the number of publications were China, the United States, Germany, Thailand, and France. The top three keywords were inflammation, oxidative stress and acute lung injury. All keywords clustering modularity Q value was 0.7483, and Silhouette S value was 0.9067; the most time-dependent keyword was 'iron overload’, and the recent hot keywords were 'autophagy’, 'septic shock’ and 'inflammation’. In the literature co-citation analysis, the Dixon and Stockwell teams had the highest citation rate. According to the analysis of countries and institutions, China and the United States had the highest research heat in this field; the journal with the highest number of citations was 'Free Radical Biology and Medicine’, the journal with the highest link strength between journals was 'Frontiers in Immunology’, and the journal with the highest number of publications was 'International Immunopharmacology’.

The research hotspots of sepsis-related ferroptosis are to inhibit the occurrence of ferroptosis, circulatory system dysfunction, organ damage and protection, inflammatory response, oxidative stress, etc. In this field, China and the United States have the largest academic influence and the gap is narrowing. However, the domestic and international cooperation network of Chinese scientific research institutions has not yet been established, and efforts need to continue to explore new ways of interdisciplinary and inter-institutional cooperation.