To investigate the effect of integrated emergency nursing process on the rescue effect of patients with acute myocardial infarction (AMI).

Ninety AMI patients admitted to Xi'an International Medical Center Hospital from August 2023 to October 2024 were selected as the research subjects, including 48 males and 42 females; The age ranged from 41 to 70 years, with an average of (60.28±7.63) years. According to the random number method, they were divided into an observation group and a control group, with 45 cases in each group. The control group received routine emergency care procedures, while the observation group received integrated medical and nursing emergency care procedures. The time nodes related to emergency treatment, including onset to balloon dilation, first medical contact to balloon dilation, hospital gate to balloon dilation, and onset to hospital gate, pre- and post-emergency cardiac function indicators, including left ventricular ejection fraction (LVEF) and left ventricular end diastolic diameter (LVEDD), major adverse cardiovascular events (MACE) during hospitalization, and nursing satisfaction were compared between two groups of patients.

The time of onset-to-ballooning, first medical contact-to-ballooning, hospital gate-to-ballooning and onset-to-hospital gate in the observation group was shorter than that in the control group (P<0.05). Compared with the same group before first-aid, LVEF was significantly increased and LVEDD was significantly decreased in both groups after first-aid (P<0.05). After first-aid, LVEF in the observation group was significantly higher than that in the control group, and LVEDD was significantly lower in the control group (P<0.05). The incidence of major adverse cardiovascular events (MACE) during hospitalization in the observation group was lower than in the control group, and the nursing satisfaction was higher than the control group (P<0.05).

Integrated emergency nursing is helpful to improve the prognosis of AMI patients, shorten the emergency process, promote the recovery of cardiac function, reduce the incidence of MACE, and improve nursing satisfaction.

To compare the effects of different emergency nursing methods in endoscopic treatment of patients with acute upper gastrointestinal bleeding.

A total of100 patients with acute upper gastrointestinal bleeding admitted to the Fifth Hospital of Huangshi City from January 2022 to December 2024 were selected; there were 55 males and 45 females, the age ranged from 27 to 65 years old, with an average of (46.03±10.23) years. They were randomly divided into an observation group and a control group, with 50 patients in each group, using a random number table. The control group received routine perioperative care, while the observation group received perioperative dual track emergency care, both of which continued until the patient was discharged. The hemostatic outcomes (immediate hemostasis success, rebleeding within 72 hours, and conversion to surgical intervention) were compared between the two groups, and the changes in self-rating depression scale (SDS), self-rating anxiety scale (SAS), hemoglobin (Hb), albumin (ALB), and prealbumin (PA) before endoscopic treatment and discharge, as well as the length of hospital stay, hospitalization costs, and nursing satisfaction were compared.

The observation group had a rebleeding rate within 72 hours of 2.00%, which was lower than the control group's 14.00% (P<0.05). At discharge, the SDS and SAS scores of the observation group were (36.04±3.51) points and (37.46±4.02) points, both of which were lower than those of the control group (40.27±3.92) points and (41.85±4.15) points (P<0.05). At discharge, the Hb, ALB, and PA levels in the observation group were (128.32±15.23) g/L, (40.11±3.52) g/L, and (225.69±15.32) mg/L, all higher than those in the control group (121.57±11.05) g/L, (36.87±3.20) g/L, and (213.25±13.07) mg/L (P<0.05). The hospitalization time and hospitalization expenses of the observation group were (6.35±1.83) days and (0.86±0.09) yuan, both of which were shorter/less than those of the control group (7.60±1.24) days and (0.92±0.13) yuan (P<0.05). The overall satisfactory rate of the observation group with nursing care was 94.00%, which was higher than the control group's 78.00% (P<0.05).

Perioperative dual track emergency nursing can help reduce the rebleeding rate of patients with acute upper gastrointestinal bleeding undergoing endoscopic treatment, alleviate negative emotions, and improve nutritional status. It is worthy of clinical promotion.

To investigate the therapeutic value and safety profile of combined nebulized budesonide and salbutamol for pediatric acute severe asthma exacerbations.

This prospective, randomized and controlled trial enrolled 94 children with acute severe asthma exacerbations treated between January 2020 and December 2024. Patients were randomly assigned to a combination therapy group (n=48, budesonide + salbutamol nebulization)and a monotherapy group (n=46, salbutamol nebulization alone). Comparative assessments included clinical efficacy evaluation, pulmonary function parameters, inflammatory biomarker modulation, symptom resolution rates, medication safety, and subsequent recurrence frequency.

The combination therapy group demonstrated significant advantages, including higher total effective rate (P<0.05), superior pulmonary function recovery, with greater improvements in FEV1, PEF, and FEV1/FVC compared to the monotherapy group (P<0.05), more pronounced reduction in inflammatory markers (IL-6, TNF-α, hs-CRP) (P<0.05), accelerated symptom resolution (wheezing, dyspnea, coughing) and shortened hospitalization duration (P<0.05), comparable adverse reaction rates (P>0.05) and significantly reduced three-month recurrence risk (P<0.05).

For children with acute severe asthma, combined budesonide-salbutamol nebulization speeds symptom relief, aids lung function recovery, reduces airway inflammation, lowers recurrence risk, and it is safe, warranting clinical promotion. This regimen offers integrated benefits and is a valuable clinical option.

To explore the preventive effect of four-step rehabilitation program combined with motivational interview on acute attack after discharge in elderly patients with heart failure.

A prospective study was conducted on 126 elderly patients with HF admitted to the First Affiliated Hospital of Shihezi University from March 2023 to July 2024. They were divided into the control group and the study group according to the random number table method, with 63 cases in each group. The control group received routine rehabilitation guidance on the basis of routine management, and the study group received four-step rehabilitation program combined with motivational interview on the basis of routine management. Cardiac function [(Left ventricular ejection fraction (LVEF), cardiac output (CO), stroke volume (SV), 6-min walking distance (6MWD)], Chinese version of Heart Failure Self-care Scale, compliance score, Minnesota Heart Failure Quality of Life Questionnaire (MLHFQ) were compared between the two groups before intervention, at discharge and 3 months after discharge, and the acute attacks within 6 months after discharge were compared between the two groups.

Before intervention, there were no differences in cardiac function, Chinese version of Heart Failure Self-care Scale, compliance score and MLHFQ score between the two groups (P>0.05). At discharge and 3 months after discharge, the LVEF, CO, SV, 6MWD, SCHFI score and compliance score of the study group were higher or greater than those of the control group, and the MLHFQ score was lower than that of the control group (P<0.05). At the last follow-up, the acute attack rate of the study group was lower than that of the control group (P<0.05).

Four-step rehabilitation program combined with motivational interview can significantly improve the cardiac function of elderly HF patients and reduce the number of acute attacks after discharge.

To analyze the research hotspots and development trends of the concept of 'ferroptosis’ in the context of sepsis, as well as the cooperation and exchange between countries, authors and institutions.

We used the method of bibliometrics to analyze the keywords, countries and institutions, authors, literature co-citation and other information of ferroptosis research in the field of sepsis from multiple perspectives with the help of CiteSpace, VOSviewer, RStudio, Excel and other software, and showed it in the form of knowledge map.

A total of 324 articles and 1378 keywords were collected in the core collection of Web of Science. The top five countries in terms of the number of publications were China, the United States, Germany, Thailand, and France. The top three keywords were inflammation, oxidative stress and acute lung injury. All keywords clustering modularity Q value was 0.7483, and Silhouette S value was 0.9067; the most time-dependent keyword was 'iron overload’, and the recent hot keywords were 'autophagy’, 'septic shock’ and 'inflammation’. In the literature co-citation analysis, the Dixon and Stockwell teams had the highest citation rate. According to the analysis of countries and institutions, China and the United States had the highest research heat in this field; the journal with the highest number of citations was 'Free Radical Biology and Medicine’, the journal with the highest link strength between journals was 'Frontiers in Immunology’, and the journal with the highest number of publications was 'International Immunopharmacology’.

The research hotspots of sepsis-related ferroptosis are to inhibit the occurrence of ferroptosis, circulatory system dysfunction, organ damage and protection, inflammatory response, oxidative stress, etc. In this field, China and the United States have the largest academic influence and the gap is narrowing. However, the domestic and international cooperation network of Chinese scientific research institutions has not yet been established, and efforts need to continue to explore new ways of interdisciplinary and inter-institutional cooperation.

To investigate the diagnostic value of scrotal ultrasonography, testicular ischemia and suspicious torsion score (TWIST) system and peripheral blood platelet volume (MPV) in testicular torsion in children.

A retrospective analysis was performed on the case data of 150 children admitted to hospital due to pain and swelling of the scrotum from August 2020 to December 2024, according to the results of testicular exploration, 92 cases were in the testicular torsion group and 58 cases in the non-testicular torsion group. The diagnostic results of scrotal color Doppler ultrasound examination and testicular exploration were compared, the color ultrasound examination of scrotum, score of TWIST system at admission and peripheral blood MPV levels at the morning after admission were compared between the two groups. The multivariate logistic regression analysis was used to analyze the risk factors of testicular torsion in children, and the receiver operating curve (ROC) to analyze the diagnostic value of scrotal ultrasonography, TWIST score and MPV alone and in combination.

The kappa consistency test between scrotal color Doppler ultrasound examination and testicular exploration was statistically significant (P<0.05). The testis volume, testicular bleeding grading (Arda grade) and TWIST system score were statistically significant differences between the two groups (P<0.05); the peripheral blood MPV levels in testicular torsion group was higher than that in the non-testicular torsion group (P<0.05). The multivariate logistic regression analysis showed that testicular volume, Arda grade, TWIST score and MPV were all risk factors for children with testicular torsion (P<0.05). ROC analysis showed that combined detection of testicular volume, Arda grade, TWIST score and MPV had higher diagnostic value for children with testicular torsion than single detection (P<0.05).

Scrotal color Doppler ultrasound has certain value in the diagnosis of testicular torsion. Combined with TWIST system score and MPV detection, it can further improve the diagnostic effect of testicular torsion in children.

To analyze the infection status and preventive measures of multidrug resistant organism (MDRO) in patients with oral and maxillofacial trauma.

A retrospective analysis was conducted on the medical records of 71 hospitalized MDRO patients with oral and maxillofacial trauma received by Huangshi Hospital of Traditional Chinese Medicine from January 2023 to February 2025, including 41 males and 30 females, the age ranged from 22 to 71 years, with an average of (53.01±7.95) years. During the same period, 78 patients with oral and maxillofacial trauma admitted to our hospital who were hospitalized but did not have MDRO infection were selected as the control group, including 37 males and 41 females, the age ranged from 20 to 73 years, with an average of (55.30±8.42) years. The distribution and drug resistance of pathogenic bacteria in MDRO infected patients were detected, and the distribution of infection sites was analyzed., and the risk factors of MDRO infection in patients with oral and maxillofacial trauma were analyzed by univariate and multivariate logistic regression analysis.

A total of 78 strains of MDRO were detected in 71 patients with oral and maxillofacial trauma, mainly Escherichia coli, MRSA and Klebsiella pneumoniae. The resistance of Escherichia coli and Klebsiella pneumoniae to cephalosporins, quinolones and sulfonamides was high, and the resistance of methiclococcus aureus to penicillins, macrolides and lincoamides was high. Univariate analysis showed that the rates of open injury, use of antibiotics ≥3 kinds, use of antibiotics ≥7 days, stay ≥10 days in MDRO patients hospitalized with oral and maxillofacial trauma were higher than those in the control group (P<0.05). Multivariate logistic regression analysis showed that open injury, use of antibiotics ≥3 kinds, use of antibiotics ≥7 d, and hospital stay ≥10 d were the risk factors for oral and maxillofacial trauma inpatient MDRO infection (P<0.05).

The MDRO in patients with oral and maxillofacial trauma is mainly composed of gram-negative bacteria, which is mostly associated with wound and lower respiratory tract infection, and is related to multiple risk factors. Clinical preventive countermeasures should be strengthened.

To explore the application effect of the fast-track nursing model based on multidisciplinary collaboration in the interventional treatment of acute type B aortic dissection.

The clinical data of 80 patients with acute type B aortic dissection admitted to our hospital from May 2023 to April 2025 were retrospectively analyzed. Among them, there were 49 males and 31 females, the age ranged from 44 to 72 years, with an average of (58.84±6.85) years. 38 patients who received the conventional nursing mode from May 2023 to April 2024 were assigned to the control group, and 42 patients who received the multidisciplinary collaborative fast-track nursing mode from May 2024 to April 2025 were assigned to the observation group. The treatment effects between the two groups were compared.

The diagnosis time, examination time, emergency stay time and transfer time of the observation group were all shorter than those of the control group (P<0.05); the success rate of treatment in the observation group was higher than that of the control group (P<0.05); The length of stay in the ICU, the time to get out of bed after surgery, and the length of hospital stay in the observation group were all shorter than those in the control group (P<0.05); the scores of the Herth Hope Scale in the observation group at 7 days after admission and at discharge were higher than those in the control group (P<0.05); there was no statistically significant difference by comparison of the total incidence of complications between the two groups (P>0.05); the total satisfaction rate of the observation group with nursing was higher than that of the control group (P<0.05).

The fast-track nursing model based on multidisciplinary collaboration is helpful to shorten the emergency process of patients undergoing interventional therapy for acute type B aortic dissection and promote the early recovery of patients.

To compare the effects of intravascular ultrasound (IUVS) and optical coherence tomography (OCT) guided emergency percutaneous coronary intervention (PCI) on acute myocardial infarction.

A total of 80 patients with acute myocardial infarction admitted to our hospital from May 2023 to November 2024 were divided into IUVS group and OCT group, with 40 cases in each group; there were 47 males and 33 females, the age ranged from 51 to 73 years, with an average of (63.51±6.59) years. Emergency PCI under IVUS guidance was performed in the IVUS group, while emergency PCI under OCT guidance was performed in the OCT group. The preoperative characteristics of lesions (plaque rupture, plaque erosion, lipid and fibrous plaques, and calcified nodules), preoperative coronary conditions [minimum lumen area (MLA), reference vessel diameter, minimum lumen diameter, lesion length, and bifurcation lesion], perioperative situation (number of stent placement, intraoperative dilation times, minimum stent area after stent placement, stent placement success rate, and length of hospital stay), detection rate of immediate stent implantation defects after PCI (stent mal-expansion, poor adhesion, immediate thrombosis, marginal dissection, and tissue prolapse), the incidence of major adverse cardiovascular events (MACE) 30 days after surgery (angina pectoris, recurrent myocardial infarction, and malignant arrhythmias) were compared between the two groups.

The plaque rupture and plaque erosion in OCT group were higher than that in the IVUS group (P<0.05); the MLA, reference vessel diameter, minimum lumen diameter, lesion length and bifurcation lesion were compared between the two groups, with statistically significant (P>0.05); the intraoperative dilation times in OCT group were more than that in IVUS group, and the hospital stay was shorter than that in IVUS group (P<0.05); the total detection rate of stent implantation defects immediately after PCI in OCT group was higher than that in IVUS group (P<0.05); there was no statistical significance in the total incidence of 30dMACE between the two groups (P>0.05).

Compared with IVUS, OCT-guided emergency PCI is better in the treatment of patients with acute myocardial infarction, which can effectively identify the nature of preoperative lesions and improve the detection rate of poor stents, shorten hospital stay, and is worthy of clinical promotion.

To explore the application effect of the teaching mode of combining DeepSeek and traditional method in the emergency and disaster teaching in medical colleges.

Two classes of third-year undergraduate students majoring in clinical medicine in Yan'an University were randomly selected and divided into a traditional teaching group (n=53) and a DeepSeek teaching group (n=30) according to different teaching plans. Students in the traditional teaching group received conventional teaching methods, while those in the DeepSeek group were taught using curriculum plans generated by DeepSeek that aligned with the teaching syllabus and met students' actual needs, with question banks developed specifically for core knowledge points. At the end of the semester, the two groups were compared in terms of theoretical scores, practical skills results, and teacher-student satisfaction evaluations.

Both groups of students underwent assessments, scoring, and a teaching satisfaction questionnaire at the end of the semester. Students in the DeepSeek group achieved higher theoretical scores than those in the traditional teaching group in pre-hospital emergency care (82.00 vs 74.00, Z=-7.02), emergency symptoms (90.00 vs 87.00, Z=-5.68), life support (89.00 vs 83.00, Z=-7.03), acute and critical diseases of the respiratory system (83.00 vs 78.00, Z=-6.23), and acute and critical diseases of the cardiovascular system (85.00 vs 75.00, Z=-7.70), with statistically significant differences (P<0.05). In terms of practical skills, the DeepSeek group also received significantly higher ratings than the traditional teaching group in tracheal intubation (4.53±0.63 vs 3.85±0.66, t=4.59) and thoracic puncture (4.46±0.72 vs 3.75±0.70, t=4.39), with statistically significant differences (P<0.05). Additionally, both teachers and students expressed higher satisfaction with the DeepSeek teaching model, and the difference was statistically significant (P<0.05).

In the emergency teaching for undergraduate clinical majors, the implementation of the DeepSeek teaching model can improve teaching quality, enhance students' initiative, and increase the satisfaction of both teachers and students, making it worthy of promotion and application.

To evaluate the hemodynamic monitoring of thoracic impedance (TEB) in patients with heart failure with preserved ejection fraction (HFpEF) and its clinical significance.

The clinical data of 100 patients admitted to the Second Hospital of Wuxi from 2022 to 2024 were analyzed retrospectively, including 73 males and 27 females. The age ranged from 56 to 72 years with an average of (64.35 7.18) years. According to the left ventricular ejection fraction (LVEF), patients were divided into control group (50 cases) with heart failure with reduced ejection fraction (HFrEF) and study group (50 cases) with HFpEF; at the same time, 50 patients without heart failure were selected as normal group. Three groups of patients were monitored for cardiac output (CO), cardiac index (CI), stroke rate (SV), heart rate index (SI), heart rate variability (HRV), preload [thoracic fluid conductivity (TFC), heart rate variability (SVV), vascular volume (IVV)], afterload [peripheral resistance per beat (SSVR), peripheral resistance index per beat (SSVRI), systemic resistance (SVR), vascular elasticity (VA)], myocardial contractility [left ventricular work per beat (LSW), left ventricular work per beat index (LSWI), pre ejection phase (PEP), left ventricular ejection time (VET)] using thoracic impedance spectroscopy (TEB), LVET, systolic time ratio (STR), ejection systolic index (EPCI), strain state index (ISI), and contractility variability (COPDI).

The LAD, STR, PEP, SSVR, and TFC values of the study group were higher than those of the normal group, while EPCI was lower than that of the normal group (P<0.05); The EPCI, LVET, LSWI, LSW, SI, SV, and CI of the control group were lower than those of the normal group, while LVDD, LAD, STR, PEP, SSVR, IVV, TFC, and HRV were higher than those of the normal group (P<0.05); The LVDD, STR, PEP, and IVV of the study group were all lower than those of the control group, while LVET, LSWI, LSW, SI, and SV were higher than those of the control group (P<0.05). After Pearson correlation analysis, STR, PEP, VA, SVR, SSVRI, SSVR, and TFC were positively correlated with the ratio of peak velocity of early diastolic blood flow (E) at the mitral valve orifice to peak velocity of early diastolic motion of the mitral annulus (e) (E/e) (P<0.05), while EPCI, LVET, LSWI, LSW, IVV, HRV, SI, SV, CI, and CO were negatively correlated with E/e (P<0.05). The ROC curve results showed that the areas under the ROC curves corresponding to STR, PEP, and TFC were 0.774, 0.808, and 0.730, respectively.

TEB hemodynamic monitoring can help to evaluate the diastolic function of the heart, if the values of IVV, LSWI, LSW, SI and SV are in the normal range, and the values of STR, PEP and TFC are rising, it can be used to assist in the diagnosis of HFpEF.

To analyze the anesthesia-related risk factors of postoperative cognitive dysfunction (POCD) after hip fracture surgery in the elderly and to explore the corresponding emergency intervention strategies.

A total of 180 elderly patients with hip fractures who were admitted to the Affiliated Hospital of Xuzhou Medical University from May 2022 to February 2025 were selected as the research subjects of this study. The incidence of POCD within 7 days after surgery in all patients was recorded, and the anesthesia-related risk factors for POCD in surgery for hip fractures in the elderly were analyzed.

Among 180 elderly patients with hip fractures, 38 cases developed POCD, with an incidence rate of 21.11%. There were statistically significant differences in the operation time, anesthesia time, anesthesia method, intraoperative dosage of propofol and remifentanil, whether dexmedetomidine was used during the operation, and the lowest intraoperative local cerebral oxygen saturation (rSO₂) between the POCD group and the non-POCD group (P<0.05). Univariate Logistic regression analysis showed that the operation time, anesthesia time, anesthesia method, intraoperative dosage of propofol and remifentanil, whether dexmedetomidine was used during the operation, and the lowest intraoperative rSO₂ were all anesthesia-related risk factors for POCD in elderly patients with hip fractures (P<0.05).

There are many anesthesia-related risk factors for POCD in surgery for hip fractures in the elderly; clinically, the incidence of POCD can be actively reduced through intervention strategies such as close monitoring of anesthesia depth, reasonable selection of anesthesia methods and anesthetic drugs, and combined rSO₂ monitoring.

To analyze the relationship between blood lactate (Lac), early lactate clearance (LCR), B-type natriuretic peptide (BNP), D-dimer (D-D) and prognosis in elderly patients with chronic obstructive pulmonary disease (COPD) complicated with respiratory failure.

The clinical data of 80 elderly patients with COPD complicated with respiratory failure admitted to the Department of Respiratory and Critical Care Medicine in Shuyang Hospital from April 2022 to February 2025 were retrospectively analyzed, and they were divided into the death group with 11 cases and the survival group with 69 cases according to the follow-up outcomes within 28 days after admission. 76 patients with COPD but without respiratory failure were set as the control group. The levels of Lac, LCR, BNP and D-D in the elderly COPD complicated with respiratory failure group and the control group, as well as different disease degrees and prognoses of elderly COPD complicated with respiratory failure were compared, the correlations between Lac, LCR, BNP, D-D levels and arterial partial pressure of oxygen (PaO₂) and arterial partial pressure of carbon dioxide (PaCO₂) in elderly patients with COPD and respiratory failure were analyzed, and the receiver operating characteristic (ROC) curve was used to analyze the prognostic value of indicators in elderly patients with COPD combined with respiratory failure.

The levels of Lac, BNP and D-D in COPD group with respiratory failure were higher than those in control group, but LCR was lower than those in control group (P<0.05).The levels of Lac, BNP and D-D levels in severe respiratory failure group were higher than those in mild-moderate respiratory failure group, and LCR was lower than those in mild-moderate respiratory failure group (P<0.05). The levels of Lac, BNP and D-D in COPD patients with respiratory failure were higher than those in survival group, and the LCR was lower than those in survival group (P<0.05). The levels of Lac, BNP and D-D were positively correlated with PaCO₂ in elderly patients with COPD combined with respiratory failure (P<0.05), the levels of Lac, BNP and D-D were negatively correlated with PaO₂ (P<0.05), the levels of LCR were negatively correlated with PaCO₂ in elderly patients with COPD combined with respiratory failure (P<0.05), and the levels of Lac, BNP and D-D were positively correlated with PaO₂ (P<0.05). ROC curve analysis showed that the AUC of the combined detection was greater than that of Lac, LCR, BNP, and D-D individually.

Lac, LCR, BNP and D-D levels in elderly patients with COPD complicated with respiratory failure have certain correlation with the severity of the disease and prognosis, and can be used for prognosis assessment.

To investigate the efficacy and safety of recombinant human brain natriuretic peptide (rhBNP) combined with levosimendan in patients with severe acute heart failure.

The clinical data of 120 patients with severe acute heart failure admitted to our hospital from April 2023 to December 2024 were retrospectively analyzed. There were 80 males and 40 females, the age ranged from 53 to 75 years, with an average of (66.32±6.03) years. They were divided into observation group and control group by the different treatment methods, with 60 cases in each group. The control group was treated with rhBNP on the basis of conventional treatment, and the observation group was combined with levosimendan; Both of them were treated for 2 weeks. The left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), N-terminal brain natriuretic peptide precursor (NT-proBNP), myocardial troponin I (cTnI), myocardial creatine kinase isoenzyme MB (CK-MB), and soluble suppression of tumorigenicity 2 (sST2), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), Minnesota heart failure quality of life (MLHFQ) score, 6-minute walking test (6MWT) at before and after treatment 2 weeks and adverse reactions were compared between the two groups.

After treatment for 2 weeks, the LVEF in observation group was significantly higher than that in control group, LVEDD and LVESE were significantly lower (P<0.05); after treatment for 2 weeks, the levels of NT-proBNP, cTnI, CK-MB, sST2, TNF-α, IL-6 and MLHFQ in observation group were significantly lower than those of the control group, and the 6MWT was significantly longer (P<0.05). But there was no statistical significance in the total incidence of adverse reactions between the two groups (P>0.05).

rhBNP combined with leveo-simendan can promote the recovery of cardiac function and improve the quality of life in patients with severe acute heart failure, which is safe and controllable, and has clinical promotion value.

To explore the establishment and validation of a risk prediction model for acute radiation dermatitis (ARD) after breast-conserving surgery for breast cancer.

A total of 123 patients who received radiotherapy after breast-conserving surgery for breast cancer in our hospital from January 2020 to October 24 were selected as the study subjects, and were included in the training set (n=86) and the validation set (n=37) according to the ratio of 7:3. According to whether patients in the training set have developed ARD, they were divided into the ARD group and the non ARD group. The occurrence of ARD in patients was recorded, and multivariate logistic regression analysis was conducted to identify risk factors for ARD, to construct a predictive model, and to validate the value of the model in clinical applications using ROC curves.

Of the 86 patients who received radiotherapy after breast-conserving surgery for breast cancer, 67 patients developed ARD (77.91%). By univariate analysis, there was no significant difference between ARD group and non ARD group in body mass index, smoking history, drinking history, hypertension, coronary heart disease, pathological type, TNM stage, triple negative breast cancer, HER2, ER and PR (P>0.05). The age in ARD group was significantly lower than that in non ARD group (42.31±7.67 vs 56.27±9.98, P<0.001); The ARD group combined with diabetes was significantly higher non ARD (34.33% vs 10.53%, P<0.05); The ARD group proportion of malnutrition was significantly higher non ARD group (43.28% vs 10.53%, P<0.01); The ARD group radiation dose was significantly higher non ARD group (57.82±3.24 vs 48.97±4.35, P<0.001). Multivariate logistic regression analysis showed that age, nutritional status, combined diabetes, radiotherapy dose entered the regression model (P<0.05), which were independent risk factors for the occurrence of radiation-induced ARD. A prediction model of radiation-induced ARD was established: P=-2.22-2.35×age+1.75×nutritional status+2.68×combined diabetes+1.99×radiation dose. The ROC curve was used to validate the predictive value of the above model for ARD occurrence. The results showed that the area under the curve was 0.876 (P=0.000, 95%CI0.828-0.924), with a sensitivity of 89.90% and a specificity of 71.00%.

Age, nutritional status, combined diabetes, radiation dose are important factors that affect the occurrence of ARD caused by radiotherapy after breast-conserving surgery for breast cancer. According to the above factors, the corresponding risk prediction model is developed, and the prediction effect of the model is good, which is worth further analysis.

To understand the first-aid knowledge, attitude and behavior level of employees in township enterprises, as well as the safety management status of enterprises, aimed to provide guidance for improving the health emergency response ability of enterprises.

From June to December 2024, the convenient sampling method was used to select employees of township enterprises in Kunshan City as the research object. The first-aid knowledge, attitude and behavior questionnaires were used for investigation; the persons in charge of enterprise safety management were Interviewed and a questionnaire was made based on the type of emergency equipment in the operating environment, quantity, usage, and the willingness of employees to receive first aid knowledge training.

A total of 3,388 employees participated in the pre-hospital first aid knowledge questionnaire, with a first-aid knowledge score of (15.23±2.14), a first-aid attitude score of (38.45±5.67), and a first-aid behavior score of (28.20±4.95); Different training experiences had statistical significance for the differences in first-aid knowledge and behavior scores. The P values were 0.001 and 0.002, respectively. There was no statistical significance for the difference in first-aid attitude score, with a (P>0.05); Questionnaires on the safety management status of 39 enterprises were prepared. Enterprises set up 100% of security personnel, and 58.97% of security personnel received first-aid training. The proportion of AED for first-aid equipment in enterprises was 25.64%, and the AED training rate of enterprise employees was 90.00%.

The first-aid knowledge of employees in township enterprises is at a medium and low level, and their first-aid attitude and behavior are at a medium level. The number and type of first-aid equipment configured by enterprises and the training of employees on the use of first aid equipment are insufficient. Safety management positions meet the requirements of fixed personnel, fixed number, fixed post, fixed responsibility and regular training. It is necessary for enterprises to strengthen the transformation of safety personnel training achievements and formulate reasonable first-aid training and drills for all personnel to improve their ability to cope with accidental injuries.

To investigate the changes in the triglyceride-glucose (TyG) index and its clinical value in patients with premature acute myocardial infarction (AMI).

A retrospective analysis was conducted on 110 patients with premature AMI who were hospitalized and definitively diagnosed in the Department of Cardiology at Changzhou Wujin People's Hospital from January 2021 to December 2022. Patients ranged in age from 22 to 64 years (average 47.60±8.35 years). Of these, 88 (80.00%) were male and 22 (20.00%) were female. For comparison, patients hospitalized during the same period were selected as controls. These control patients lacked typical angina symptoms, showed stenosis of <50% in major coronary vessels (≥2.0 mm) on coronary angiography, and had an age of onset of <55 years for males or <65 years for females. Ages ranged from 29 to 64 years (mean 53.33±6.65). Of these, 80 were men (33.76%) and 157 were women (66.24%). The TyG index was compared between the two groups, and subgroup analysis was performed by gender. Logistic regression analysis was used to explore the association between the TyG index and premature AMI, and receiver operating characteristic (ROC) curve analysis was employed to evaluate the diagnostic value of the TyG index for premature AMI.

Patients in the premature AMI group had significantly lower age and HDL-C levels than the control group, while exhibiting significantly higher proportions of males, fasting blood glucose, LDL-C, and HbA1c levels. The TyG index was significantly higher in the premature AMI group compared to the control group (10.53±0.78 vs. 10.20±0.55, P<0.001). Subgroup analysis by sex revealed that the TyG index remained significantly higher in the premature AMI group for both male and female subgroups. Logistic regression results indicated that the TyG index was an independent influencing factor for premature AMI (OR=1.664, 95% CI=1.102-2.513, P=0.015). The area under the ROC curve for the TyG index in diagnosing premature AMI was 0.634 (95% CI: 0.570-0.698, P<0.001), with a sensitivity of 0.545 and specificity of 0.692.

The TyG index is significantly elevated in patients with premature AMI and is an independent correlated factor for premature AMI.