Characteristics of changes in serum zinc and related inflammatory factors in HIV/TB co-infected patients during the occurrence of immune reconstitution inflammatory syndrome

doi:10.3877/cma.j.issn.2095-9133.2024.04.005

Abstract

Abstract:

Objective

To investigate the changes in serum zinc and associated inflammatory factors in human immunodeficiency virus/tuberculosis （HIV/TB） co-infected individuals following the development of immune reconstitution inflammatory syndrome （IRIS） during antiretroviral therapy （ART）， as well as to assess their clinical implications.

Methods

A total of 83 patients with co-infection of HIV/TB were involved in this study with follow-up. According to the occurrence of TB/IRIS during ART， the patients were divided into IRIS group （34 cases） and no-IRIS group （49 cases）. In addition， healthy individuals without HIV/TB （40 cases） were also enrolled as control. Serum levels of zinc and related inflammatory factors were analyzed and compared between different groups.

Results

The serum zinc concentration in the IRIS group of HIV/TB co-infected patients was lower than that in the control group of HIV-infected patients and also lower than that in the no-IRIS group of HIV/TB co-infected patients.

Conclusion

Zinc deficiency may be a potential factor in the occurrence of tuberculosis-related immune reconstitution inflammatory syndrome.

Key words: Human immunodeficiency virus, Tuberculosis, HIV/TB, IRIS, Zinc

Fang Zhao, Yuao Deng, Man Rao, Yu Liu, Qiuxia Deng, Qiuyue Zhang, Haitao Zhang, Ying Song, Siyuan Wang, Xinyun Jia, Yingxia Liu. Characteristics of changes in serum zinc and related inflammatory factors in HIV/TB co-infected patients during the occurrence of immune reconstitution inflammatory syndrome[J]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2024, 10(04): 213-217.

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References 13

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组别	例数	年龄［岁（范围）］	性别［例（%）］	HIV病毒载量（log10copies/mL）	CD4⁺T细胞计数（cells/μL）
组别	例数	年龄［岁（范围）］	男性	HIV病毒载量（log10copies/mL）	CD4⁺T细胞计数（cells/μL）
HIV组	40	38.27±7.62（22～63）	36（90.00）	5.54±0.69	121.00±73.40
no-IRIS组	49	38.21±8.68（23～64）	44（89.80）	5.33±0.69	130.61±78.02
IRIS组	34	40.77±9.26（18～56）	31（91.18）	5.68±0.78	114.78±64.30
F/χ²值		1.15	0.05^a	2.51	0.51
P值		＞0.05	＞0.05	＞0.05	＞0.05

组别	例数	年龄［岁（范围）］	性别［例（%）］	HIV病毒载量（log10copies/mL）	CD4⁺T细胞计数（cells/μL）
组别	例数	年龄［岁（范围）］	男性	HIV病毒载量（log10copies/mL）	CD4⁺T细胞计数（cells/μL）
HIV组	40	38.27±7.62（22～63）	36（90.00）	5.54±0.69	121.00±73.40
no-IRIS组	49	38.21±8.68（23～64）	44（89.80）	5.33±0.69	130.61±78.02
IRIS组	34	40.77±9.26（18～56）	31（91.18）	5.68±0.78	114.78±64.30
F/χ²值		1.15	0.05^a	2.51	0.51
P值		＞0.05	＞0.05	＞0.05	＞0.05

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