Application value of plasma NT-proBNP in diagnosis and treatment and prognosis assessment for acute heart failure patients

doi:10.3877/cma.j.issn.2095-9133.2016.04.011

Abstract

Abstract:

Objective

To explore the application value of plasma NT- proBNP in early diagnosis and treatment and prognostic assessment for acute heart failure (AHF) patients.

Methods

Total 127 cases of AHF patients were collected in the Emergency Department of our hospital between January 2014 and December 2015. These cases were divided into 4 groups according to the NYHA classification of cardiac function: cardiac function grade Ⅰ group, cardiac function grade Ⅱ group, cardiac function grade Ⅲ group and cardiac function grade Ⅳ group. The relationship was o observed between plasma NT- proBNP, left ventricular ejection fraction (LVEF) and the happening of the major adverse cardiovascular events (MACE) in the AHF patients of different cardiac function grade groups.

Results

The increased level of plasma NT- proBNP was positively related to the NYHA classification of cardiac function, negatively related to LVEF; the reduced level of plasma NT- proBNP after the treatment for 1 week, was negatively related to the NYHA classification of cardiac function and the happening of MACE.

Conclusion

Plasma NT- proBNP has important value in early diagnosis and treatment and prognosis assessment for acute heart failure patients.

Key words: AHF, NT-proBNP, LVEF, MACE, Prognosis assessment

Huimin Luo, Shaohui Liu, Mingfeng He, Kuangyi Li, Zhixin Wu. Application value of plasma NT-proBNP in diagnosis and treatment and prognosis assessment for acute heart failure patients[J]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2016, 02(04): 245-247.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhwsyjdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-9133.2016.04.011

https://zhwsyjdzzz.cma-cmc.com.cn/EN/Y2016/V02/I04/245

Figures/Tables 2

References 6

1	侯光友，李冰，徐华丽，等. BNP/NT-proBNP在心力衰竭诊断治疗中的应用进展[J]．实用医药杂志，2013，30(12)：1123-1125.
2	中华医学会心血管病学分会，中华心血管病杂志编辑委员会．急性心力衰竭诊断和治疗指南[J]．中华心血管病杂志，2010，38(3)：195-208.
3	安红姬．急性心功能不全患者血浆B型钠尿肽的检测及临床意义[J]．中国卫生产业，2014, 25：95-96.
4	Januzzi JL Jr, Camargo CA, Anwaruddin S, et al.The N-terminal pro-BNP investigation of dyspnea in the emergency department(PRIDE) study[J]. Am J Cardiol, 2005, 95(9): 948-954.
5	Bayes-Genis A, Santalo-Bel M, Zapico-Muniz E, et al.N-terminal pro-brain natriuretic peptide(NT-proBNP) in the emergency diagnosis and in-hospital monitoring of patients with dyspnoes and ventricular dysfunction[J]. Eur Heart Fail, 2004, 6: 301-308.
6	James L. Januzzi.Jr, Roland RJ van Kimmenade, John Lainchbury, et al.The Value of NT-porBNP for the Evaluation of Acute CHF: A Multicenter, International Meta-Analysis of 1256 Subyects(ICON) study[J]. Eur Heart J, 2006, 27: 330.

组别	例数	治疗前血浆NT-proBNP水平(pg/mL)	LVEF(%)
心功能分级Ⅰ级	28	2 174.4±859.2	58.35±6.3
心功能分级Ⅱ级	33	5 729.8±1 493.7^a	51.83±7.4^a
心功能分级Ⅲ级	35	12 478.4±3 128.8^ab	46.7±9.2^ab
心功能分级Ⅳ级	31	20 389.7±4 462.4^abc	38.2±9.7^abc

组别	例数	治疗前血浆NT-proBNP水平(pg/mL)	LVEF(%)
心功能分级Ⅰ级	28	2 174.4±859.2	58.35±6.3
心功能分级Ⅱ级	33	5 729.8±1 493.7^a	51.83±7.4^a
心功能分级Ⅲ级	35	12 478.4±3 128.8^ab	46.7±9.2^ab
心功能分级Ⅳ级	31	20 389.7±4 462.4^abc	38.2±9.7^abc

心功能分级	例数	治疗前血浆NT-proBNP水平(pg/mL，±s)	治疗后血浆NT-proBNP水平(pg/mL，±s)	治疗前后血浆NT-proBNP水平下降幅度(%)	MACE[例(%)]
心功能分级Ⅰ级	28	2 174.4±859.2	318.7±21.5^a	85.3	1(3.6)
心功能分级Ⅱ级	33	5 729.8±1 493.7	1 274.3±362.4^a	77.8	4(12.1)
心功能分级Ⅲ级	35	12 478.4±3 128.8	67 62.6±1 262.7^a	45.8	11(31.4)
心功能分级Ⅳ级	31	20 389.7±4 462.4	12 748.8±3 826.5^a	37.5	16(51.6)

心功能分级	例数	治疗前血浆NT-proBNP水平(pg/mL，±s)	治疗后血浆NT-proBNP水平(pg/mL，±s)	治疗前后血浆NT-proBNP水平下降幅度(%)	MACE[例(%)]
心功能分级Ⅰ级	28	2 174.4±859.2	318.7±21.5^a	85.3	1(3.6)
心功能分级Ⅱ级	33	5 729.8±1 493.7	1 274.3±362.4^a	77.8	4(12.1)
心功能分级Ⅲ级	35	12 478.4±3 128.8	67 62.6±1 262.7^a	45.8	11(31.4)
心功能分级Ⅳ级	31	20 389.7±4 462.4	12 748.8±3 826.5^a	37.5	16(51.6)

[1]	Pei Yang, Jing Wu. Review of disease burden of knee osteoarthritis and pharmacoeconomics of cross-linked sodium hyaluronate [J]. Chinese Journal of Joint Surgery(Electronic Edition), 2019, 13(01): 109-113.
[2]	Miaomiao Shao, Qing Cheng, Ying Li, Weiwei Guan, Lihua Hu, Xiaoling Wang. Stability study of commonly used drugs in children after abdominal surgery compatibility with pediatric electrolyte supplements injection [J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2022, 18(06): 731-738.
[3]	Chuanbo Xie, Qin Man, Hong Luo. Values of artificial intelligence breast ultrasound in diagnosis and prognosis assessment of breast carcinoma [J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2020, 16(03): 368-372.
[4]	Keren Luo, Jun Tang. Research advances in the composition and function of pulmonary surfactant [J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2019, 15(02): 137-142.
[5]	Xiaoping Shi, Donghui Lao, Jing Wang, Qianzhou Lyu, Xiaoyu Li, Qing Xu. Drug-related problems identified in liver transplant recipients in the intensive care unit [J]. Chinese Journal of Transplantation(Electronic Edition), 2023, 17(02): 104-111.
[6]	Yane Zheng, Hui Luo, Hang Yang, Dayong Sun. Effect of bi-level noninvasive positive pressure ventilation on NT-proBNP and hs-CRP in patients with emergency type Ⅱ respiratory failure and heart failure [J]. Chinese Journal of Lung Diseases(Electronic Edition), 2020, 13(02): 236-241.
[7]	Zhenyu Yang, Yao Tong, Kai Tan. Emergency management and protective measures for patients with liver cancer during the outbreak of novel coronavirus [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2020, 09(02): 97-100.
[8]	Lizi Jin, Ani Wang, Tingting Su, Junyong Han, Fang Zhou, Bairong Chen. Correlation between NT-proBNP and SYNTAX score of STEMI patients [J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2020, 08(03): 252-255.
[9]	Xiang Li. Correlation of plasma levels of NT-proBNP and GHbA1c with severity of coronary artery disease in patients with coronary heart disease [J]. Chinese Journal of Heart and Heart Rhythm(Electronic Edition), 2017, 05(03): 149-152.
[10]	Nana Guo, Xuejun Liu, Yufeng Du. Advances in management of chronic obstructive pulmonary disease [J]. Chinese Journal of Geriatrics Research(Electronic Edition), 2017, 04(04): 28-32.
[11]	Maoxing Yue, Peigen Zhou, Donglin Hao, Ying Li, Jinnan Yin, Qihan Zheng, Xuefeng Yang, Bing Mei, Zhihui Sun, Linqing Ma, Bingxin Xu, Jing Wu, Juan Wu, Tingting Yu, Yichao Qian, Xiaodie Zhu, Bin Feng, Junchen Xu, Zhuying Guan, Hui Yue, Yanhong Wei. Therapeutic effect of a pharmaceutical composition on promoting nerve repair in amyotrophic lateral sclerosis: report of twenty-two cases with follow-up for one year [J]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2018, 04(05): 264-272.
[12]	Maoxing Yue, Peigen Zhou, Donglin Hao, Ying Li, Jinnan Yin, Qihan Zheng, Xuefeng Yang, Bing Mei, Zhihui Sun, Linqing Ma, Jing Wu, Juan Wu, Tingting Yu, Yichao Qian, Xiaodie Zhu, Bin Feng, Junchen Xu, Zhuying Guan, Hui Yue, Yanhong Wei, Dezhi Zhuang, Hua Chang, Ruixiu Tang, Xiaoli Huang. Therapeutic effect of a pharmaceutical composition on promoting nerve repair in motor neuron disease: report of 66 cases with follow-up for six months [J]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2018, 04(05): 281-289.

Please choose a citation manager

Content to export