To evaluate the effects of ulinastatin on the enzymology of acute pancreatitis induced by acute organophosphorus poisoning.

Retrospective analysis was made to 55 cases of AOPP patients with AP admitted to the emergency department of Liaocheng People’s Hospital fromJanuary 2016 toJanuary 2017, including 24 males, 31 females, aged from 19 to 70 years old[(47.3+ 10.7) years old]. Patients were randomly divided into UTI intervention group (n=25) and control group (n=30). The control group was treated with conventional therapy. The UTI intervention group was treated with UTI (100, 000 U UTI + 5% glucose injection 250 mL, intravenous infusion, q 8 h). The degree and relief time of abdominal pain in two groups of patients were compared and the changes of blood cholinesterase (AchE), serum amylase, urine amylase and lipase before and after 2, 3, 5, 7 days treatment in two groups were also observed. The time of serum and urine levels of amylase returned to normal, hospitalization time and total treatment efficiency were compared.

The abdominal pain relief time [(35.46±6.58) h], abdominal tenderness alleviate [(48.26±8.46) h] time in the UTI intervention group were shorter than those in the control group [ (48.25±8.31) h, (68.54±9.93) h] (P<0.05). The levels of AchE in the UTI intervention group in 5, 7 day was higher than that in the control group (P<0.05). The levels of serum amylase and lipase in the UTI intervention group in the 3, 5 and 7 days were lower than those in the control group (P<0.05). The levels of urine amylase in the UTI intervention group in 5, 7 day was lower than those in the control group (P<0.05). UTI intervention group The hospitalized time [(8.13+ 1.23) d], serum and urine amylase returned to normal range of time [(6.68±1.03) d and(7.23.6±1.15) d] in UTI group are shorter than those in the control group [(13.25±2.11) d、(9.07±1.45) d与(11.35±2.05) d], and the difference is statistically significant (P<0.05). The total effective rate in the UTI intervention group was [95.6% (24/25)] was significantly higher than that in the control group [80.9%, (23/30)] (P<0.05).

UTI can promote AchE recovery, inhibit the release of serum and urine amylase and lipase and play an positive role in the treatment of AOPP patients with AP. The clinical effect is significant.