To investigate the clinical significance of the changes in plasma N-terminal precursor natriuretic peptide(NT-pro-BNP ) and c-reactive protein (CRP) in patients with hypertensive cerebral hemorrhage.

Total 65 cases of hypertensive cerebral hemorrhage patients were collected in the Department of Critical Care Medicine of our hospital between January 2016 and December 2016 (observation group), and 30 cases of healthy physical examination people were select as control at the same time (control group). Plasma levels of NT-pro-BNP and CRP were compared between observation group and control group. In the observation group, according to the Glasgow coma score (GCS) , the patients were divided into two groups, the GCS score≤8 group, and the GCS score>8 group. According to the prognosis of disease, the patients were divided into survival group and death group. The differences of plasma levels of NT-pro-BNP and CRP between two subgroups were compared.

The levels of NT-pro-BNP and CRP in the observation group were higher than that in the controll group, [NT-pro-BNP: (823.67±3 095.51)pg/L 、(43.60±51.06)pg/L, CRP: (52.26±52.50)mg/L 、(1.25±2.29)mg/L, P<0.05]. The levels of NT-pro-BNP and CRP in the death group of hypertensive cerebral hemorrhage were higher than that in the survival group, [NT-pro-BNP: (2 172.50±5 272.32)pg/L、(179.92±143.75)pg/L, CRP: (98.50±59.16)mg/L 、(30.19±30.53)mg/L, P<0.05]. The CRP level of GCS score≤8 group was higher than that of the GCS score>8 group, [(73.04±56.34)mg/L、(26.45±32.98)mg/L, P<0.05], but the difference of the NT-pro-BNP level in the two groups was not statistically significant (P>0.05).

Plasma NT-pro-BNP and CRP levels in patients with hypertensive cerebral hemorrhage were higher than normal healthy people. The CRP level can reflect the severity of the disease. Combination of NT-pro-BNP and CRP levels can be used as indicators of prognosis.