To analyze the diagnostic value of 8-OHdG, MDA, SOD and T-AOC in patients with stroke.

The levels of serum 8-hydroxydeoxyguanosine monophosphate (8-OHdG), malondialdehyde (MDA) and superoxide dismutase (SOD) in 102 cases of ischemic stroke (IS group), 98 cases of hemorrhagic stroke (ICH group) and 95 healthy subjects (the normal control group), were detected by enzyme-linked immunosorbent assay (ELISA). Total antioxidant capacity (T-AOC) of three groups was detected by phenanthroline colorimetric method. The area under the ROC curve was used to analyze the diagnostic value of 8-OHdG, MDA, SOD and T-AOC in stroke.

Serum 8-OHdG and MDA levels in the IS and ICH groups were higher than that of the normal control group (P<0.05). SOD and T-AOC levels in the IS and ICH groups were lower than that of the normal control group (P<0.05). The levels of serum 8-OHdG, SOD and T-AOC in the IS group were higher than those in the ICH group (P<0.05), while there was no significant difference between the two groups (P>0.05). 8-OHdG was positively correlated with MDA, SOD, T-AOC levels (P<0.01), MDA was not correlated with SOD (P>0.05), and MDA was positively correlated with T-AOC (P <0.05). The specificity of 8-OHdG, MDA, SOD and T-AOC in diagnosing IS and healthy subjects was 84%, 82%, 89% and 91%, respectively. The specificity of 8-OHdG, MDA, SOD and T-AOC in the diagnosis of ICH and healthy persons was 71%, 84%, 79% and 72%, respectively. 8-OHdG and T-AOC were closely related to stroke and protective factors for stroke. MDA and SOD were closely related to stroke and are risk factors for stroke.

Serum 8-OHdG, MDA, SOD and T-AOC are sensitive indicators of oxidative stress in stroke patients. The levels of 8-OHdG, SOD and T-AOC are significantly correlated with the severity of stroke, and have a high practical value for the differential diagnosis of stroke patients.