Abstract:
Objective To explore the predictive value of 2019 New Coronavirus (2019-nCoV) antibody to the relapse of 2019-nCoV infected patients after discharge.
Methods 22 patients with 2019-nCoV infection admitted to the first people's Hospital of Zhaoqing City from January to April 2020 were selected, including 13 males and 9 females; The average age was (35.95±17.88) years (range, 3-65 years). The 2019-nCoV infected patients who were negative for 2019-nCoV nucleic acid were taken as control group 2 weeks after discharge. The positive 2019-nCoV infected with 2019-nCoV nucleic acid were treated as Fuyang group. The levels of 2019-nCoV antibody in the two groups were compared, and the ROC curve was drawn to evaluate the predictive value of 2019-nCoV antibody to the recovery of 2019-nCoV infected patients after discharge.
Results There was no significant difference in serum IgM level between Fuyang group and control group at discharge (P>0.05). The serum IgG level at discharge in the two groups was significantly lower than that in the control group (P<0.05). ROC curve analysis showed that the area under the curve (AUC) of 2019-nCoV IgG in predicting the recovery of positive after discharge was 0.876, the sensitivity was 81.8%, and the specificity was 90.9%.
Conclusion The level of IgG at discharge has a high value in predicting the recovery of positive after discharge in patients with 2019-nCoV infection, which can be used as a predictor of the recovery of positive after discharge in patients with 2019-nCoV infection.
Key words:
2019-nCoV infection,
2019-nCoV antibody,
re-positive nucleic acid of 2019-nCoV
Xiaogang Wang, Huiling Wang, Yulu Huang, Hongbing Yao. Predictive value of COVID-19 antibody in patients with re-positive nucleic acid[J]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2021, 07(03): 133-136.