To explore the effect of "four step" training mode for all staff in hospital infection control on monitoring indicators of nosocomial infection.

From June 25 to September 30, 2019, the whole staff of the First Affiliated Hospital of Nanjing Medical University (Jiangsu Provincial People's Hospital) were trained on the knowledge and skills of infection prevention and control by the "four step" training mode. The training contents include basic knowledge of nosocomial infection, hand hygiene, occupational exposure prevention and disposal, disinfection and sterilization, medical waste management, standardized inspection, multi drug resistant bacteria prevention and control, infectious disease management, etc. Monitoring indicators included hospital infection rate, hospital infection case rate, surgical incision infection rate, three tube infection rate of ICU patients, microbial sample submission rate before the use of therapeutic antibiotics, hand hygiene compliance and accuracy rate.

After the implementation of the "four step" sensing and control full staff training, the incidence of nosocomial infection in the whole hospital, internal medicine, surgery, geriatrics and ICU ward decreased (P<0.05), the infection rate of surgical site in the whole hospital decreased from 0.66% to 0.42%, and the infection rate of class I and class II surgical incision was also lower than that before the implementation of the training (P<0.05). There was no significant difference in the infection rate of class III surgical incision before and after the implementation of the training, The infection rate of three tubes in intensive care unit (ICU) patients did not change after the implementation of "four step" full staff training. The submission rates of all kinds of antibiotics, restricted antibiotics and special antibiotics in the whole hospital were improved (P<0.05), and the hand hygiene compliance and accuracy of nurses were improved (P<0.05), Although the compliance of hand hygiene was improved after the implementation of the training, there was no statistical difference in the correct rate (P>0.05).

The "four step" training and assessment mode for all staff of infection control and prevention has a positive feedback effect on the monitoring indicators of nosocomial infection, and the level of nosocomial infection prevention and control has been significantly improved.