[Abstract] Objective To compare the efficacies of oxycodone and sufentanil administrated in non-intubation thoracoscopic surgery.

A total of 50 patients including 28 males and 22 females undergoing non-intubation thoracoscopic surgery were randomly divided into two groups with 25 patients in each group, the age ranged from 18 to 35 years old, and the average age was (26.3±4.7) years old. After performing the thoracic paravertebral nerve block (T₄、T₅) , the patients were induced with dexmedetomidine (1 μg/kg ) and propofol (4 μg/mL TCI), and then 0.2 mg/kg oxycodone and 0.2 μg/kg sufentanil were administrated respectively in group O and S. The anesthesia was maintained with propofol and sevoflurane and all patients were kept spontaneous breathing with the aid of LMA mask. During the process of surgery, the results of blood gas analysis were recorded respectively at the moment of in operating room (T₀), 15min, 30min after Laryngeal mask ventilation (T₁、T₂), 30min after surgery (T₃). The time-weighted average V_T, f, SpO₂ and P_ETCO₂ were calculated. In addition, the intraoperative cough and Nausea and vomiting 24h after surgery were recorded.

(1) Compared with that of the patients in group S, the PH, PaO₂ in group O were risen at T₁ and T₂, while the PaCO₂ were reduced(P<0.05). (2) Compared with that of the patients in group S, the TWA-V_T and TWA-f in group O were increased, while the TWA-P_ETCO₂ were decreased(P<0.05). (3) The intraoperative and postoperative incidence of adverse reactions in group O were less than that of patients in group S(P<0.05).

For the patients undergoing non-intubation thoracoscopic surgery, oxycodone can optimize intraoperative respiratory management and ameliorate the intraoperative and postoperative incidence of adverse reactions.