To explore the application of thromboelastography (TEG) in the diagnosis of coagulation dysfunction after early burns.

Burn patients admitted to the Department of Burn Surgery of the Third Affiliated Hospital of Inner Mongolia Medical University in the past two years were collected and the patients were divided into post-burn coagulation dysfunction group and post-burn non-coagulation dysfunction group. TEG test and routine coagulation and platelet count test were performed in the two groups, and the relevant results were counted and analyzed.

The post-burn coagulopathy group and the non-coagulopathy group had statistically significant difference in mean burn total area (TBSA%) [(37.95±15.34) vs. (11.62±4.17), t=-11.40] (P<0.05). There were statistically significant differences in burn severity (χ²=30.75) and inhaled injury (χ²=20.47) between the coagulopathy group (7 cases of mild, 8 cases of moderate, 22 cases of severe, 9 cases of extremely severe, and 26 cases of inhaled injury) and the non-coagulopathy group (31 cases of mild, 9 cases of moderate, 6 cases of severe, 1 case of extremely severe, and 5 cases of inhaled injury) (P<0.05). In the diagnosis of post-burn coagulation dysfunction, TEG was consistent with conventional coagulation and platelet tests (k=0.664, P<0.05). Correlation analysis of TEG parameters and routine coagulation and platelet results in post-burn coagulation disorder group showed that R value was positively correlated with APPT (r= 0.418, P<0.05); K value was negatively correlated with FIB and PLT (r=-0.15, -0.413, P<0.05); α-Angle was positively correlated with FIB, PLT, D-dimer (r=0.618, 0.372, P<0.421, P<0.05), and negatively correlated with PT (r=-0.212, P<0.05); MA value was positively correlated with FIB, D-dimer and PLT (r=0.29, 0.249, 0.743, P<0.05); CI value was negatively correlated with APTT (r=-0.55, P<0.05). ROC curve analysis showed that the area under the curve (AUC)of α angle and MA value were 0.616, 0.754, and the sensitivity was 0.617, 0.742, and the specificity was 0.705, 0.681, respectively. The area under the curve of PT and PLT was 0.656, 0.676, the sensitivity was 0.438, 0.469, and the specificity was 0.857, 0.632, repectively; the difference was statistically significant (P<0.05).

TEG detection is more valuable in the diagnosis of coagulation dysfunction after early burn than the conventional detection of coagulation and platelet count, which is worthy of clinical application.