To explore the feasibility of transcranial color Doppler ultrasound (TCCD) to monitor the changes of cerebral blood flow in patients with different intraoperative blood pressure and carbon dioxide partial pressure.

Thirty patients with laparoscopic elective surgery were selected, including 16 males and 14 females, aged 25~70 years, with an average age of (57lective surgery were selectedtranscranial Doppler and TCCD were used to measure the middle cerebral artery blood flow spectrum of all the patients, and to monitor cerebral oxygen saturation (rcSO₂) throughout the process after anesthesia. At the same time, TCCD was used to measure and calculate cerebral blood flow after anesthesia induction at the time point of when the blood pressure was normal, P_ETCO₂ was ect mmHg (T1), 35 mmHg-45 mmHg (T2), and ti mmHg (T3), respectively; when the blood pressure decreased by more than 30%, P_ETCO₂ was ect mmHg (T4), 35 mmHg-45 mmHg (T5) and o45 mmHg (T6), respectively.

Compared with the normal blood pressure, the cerebral arterial blood flow decreased significantly when the blood pressure decreased by more than 30% (F=49.73, P<0.010). When the blood pressure was maintained, with the gradual increase of P_ETCO₂, the cerebral arterial blood flow also gradually increased (F=50.33, P<0.010), and blood pressure had an interaction with the influence of P_ETCO₂ (F=3.21, P<0.050). TCCD had a good correlation with TCD and rcSO₂.

TCCD can effectively monitor the changes of intraoperative cerebral blood flow in real time, and has a good correlation with TCD, rcSO₂, and therefore it has good clinical application value.