Effect of troponin I elevation on prognosis in patients with acute non-traumatic cerebral hemorrhage

doi:10.3877/cma.j.issn.2095-9133.2026.01.001

Abstract

Abstract:

Objective

To analyze the influence factors of elevated troponin I (cTnI) in patients with acute non-traumatic cerebral hemorrhage.

Methods

A total of 138 patients with acute non-traumatic intracerebral hemorrhage admitted to The First People’s Hospital of Chun'an County from April 2022 to April 2024 were enrolled as study subjects, including 76 males and 62 females. The patients were aged 50 to 70 years, with a mean age of (58.99±5.98) years. According to the serum level of cardiac troponin I (cTnI), the patients were divided into two groups: the elevated cTnI group (cTnI≥0.04 ng/mL, n=44) and the normal cTnI group (cTnI<0.04 ng/mL, n=94). Compared with the general data of the two groups, multivariate logistic regression model was used to analyze the influencing factors of cTnI, and restricted cubic spline was used to evaluate the relationship between cTnI and prognosis.

Results

Glasgow coma score and the estimated glomerular filtration rate (eGFR) were lower at admission in the elevated group (GCS), as compared to the normal group, The hematoma volume and hemorrhage involvement in the insula area were higher than those in the normal group (P<0.05); Multivariate logistic regression analysis showed that the risk of elevated cTnI level in patients with acute non-traumatic intracerebral hemorrhage was associated with high eGFR (OR=0.977,95% CI: 0.956~0.997), high GCS score (OR=0.272, 95% CI: 0.160~0.462), bleeding involvement of island region (OR=3.948, 95% CI: 1.139~13.679), and hematoma volume (OR=1.145, 95% CI: 1.045~1.254) (all P<0.05); Of the 138 patients, In 37 patients, the mRS scores from 4 to 6 were classified as poor prognosis. Taking the prognosis as the dependent variable, the restrictive cubic spline plot showed that with the increasing levels of cTnI, the greater the risk of having a poor prognosis was noted, with non-linear dose-response relationship between cTnI and prognosis (P<0.05).

Conclusion

Elevated cTnI is associated with eGFR, GCS score, hemorrhage involvement of the insula region, and hematoma volume, and cTnI levels showed a non-linear dose-response relationship with outcome in patients with acute non-traumatic ICH.

Key words: Troponin I, Acute non-traumatic cerebral hemorrhage, Influencing factors, Prognosis

Qiaoxin Zheng, Jianxian Wang, Xunhong Xu. Effect of troponin I elevation on prognosis in patients with acute non-traumatic cerebral hemorrhage[J]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2026, 12(01): 1-5.

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References 30

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组别	例数	性别[例（%）]		年龄（岁）	吸烟史	体质量指数（kg/m²）	高血压[例（%）]	糖尿病[例（%）]
组别	例数	男性	女性	年龄（岁）	吸烟史	体质量指数（kg/m²）	高血压[例（%）]	糖尿病[例（%）]
升高组	44	26（59.09）	18（40.91）	58.95±6.68	22（50.00）	22.26±1.46	16（36.36）	11（25.00）
正常组	94	50（53.19）	44（46.81）	59.01±5.67	48（51.06）	22.19±1.34	30（31.91）	20（21.28）
χ²/t值		0.42		0.05	0.01	0.28	0.27	0.24
P值		>0.05		>0.05	>0.05	>0.05	>0.05	>0.05
组别	例数	冠心病[例（%）]	入院收缩压（mmHg）	入院舒张压（mmHg）	血糖（mmol/L）	受伤至入院时间（h）	入院时GCS评分（分）	破入脑室[例（%）]
升高组	44	12（27.27）	138.26±20.15	86.26±7.58	6.21±1.34	6.26±2.11	8.14±1.11	8（18.18）
正常组	94	24（25.53）	136.98±21.69	86.94±6.12	6.18±1.29	6.15±1.98	9.48±1.08	16（17.02）
χ²/t值		0.05	0.33	0.52	0.12	0.30	6.73	0.03
P值		>0.05	>0.05	>0.05	>0.05	>0.05	<0.001	>0.05
组别	例数	合并蛛网膜下腔出血[例（%）]	出血累及岛叶区域[例（%）]	血肿体积（mL）	eGFR（mL/min）	血小板计数（×10⁹/L）	白细胞计数（×10⁹/L）	血红蛋白（g/L）
升高组	44	6（13.64）	12（27.27）	25.25±6.10	90.16±22.87	195.65±42.25	9.33±1.64	132.68±20.22
正常组	94	12（12.77）	11（11.70）	23.02±5.09	99.00±21.87	198.42±40.63	9.29±1.71	134.02±19.68
χ²/t值		0.02	5.23	2.25	2.18	0.37	0.13	0.37
P值		>0.05	<0.05	<0.05	<0.05	>0.05	>0.05	>0.05

组别	例数	性别[例（%）]		年龄（岁）	吸烟史	体质量指数（kg/m²）	高血压[例（%）]	糖尿病[例（%）]
组别	例数	男性	女性	年龄（岁）	吸烟史	体质量指数（kg/m²）	高血压[例（%）]	糖尿病[例（%）]
升高组	44	26（59.09）	18（40.91）	58.95±6.68	22（50.00）	22.26±1.46	16（36.36）	11（25.00）
正常组	94	50（53.19）	44（46.81）	59.01±5.67	48（51.06）	22.19±1.34	30（31.91）	20（21.28）
χ²/t值		0.42		0.05	0.01	0.28	0.27	0.24
P值		>0.05		>0.05	>0.05	>0.05	>0.05	>0.05
组别	例数	冠心病[例（%）]	入院收缩压（mmHg）	入院舒张压（mmHg）	血糖（mmol/L）	受伤至入院时间（h）	入院时GCS评分（分）	破入脑室[例（%）]
升高组	44	12（27.27）	138.26±20.15	86.26±7.58	6.21±1.34	6.26±2.11	8.14±1.11	8（18.18）
正常组	94	24（25.53）	136.98±21.69	86.94±6.12	6.18±1.29	6.15±1.98	9.48±1.08	16（17.02）
χ²/t值		0.05	0.33	0.52	0.12	0.30	6.73	0.03
P值		>0.05	>0.05	>0.05	>0.05	>0.05	<0.001	>0.05
组别	例数	合并蛛网膜下腔出血[例（%）]	出血累及岛叶区域[例（%）]	血肿体积（mL）	eGFR（mL/min）	血小板计数（×10⁹/L）	白细胞计数（×10⁹/L）	血红蛋白（g/L）
升高组	44	6（13.64）	12（27.27）	25.25±6.10	90.16±22.87	195.65±42.25	9.33±1.64	132.68±20.22
正常组	94	12（12.77）	11（11.70）	23.02±5.09	99.00±21.87	198.42±40.63	9.29±1.71	134.02±19.68
χ²/t值		0.02	5.23	2.25	2.18	0.37	0.13	0.37
P值		>0.05	<0.05	<0.05	<0.05	>0.05	>0.05	>0.05

自变量	β	SE	Wald	P值	OR	95% CI
自变量	β	SE	Wald	P值	OR	下限	上限
eGFR	-0.024	0.011	5.009	<0.05	0.977	0.956	0.997
GCS评分	-1.302	0.271	23.132	<0.001	0.272	0.160	0.462
出血累及岛叶区域	1.373	0.634	4.690	<0.05	3.948	1.139	13.679
血肿体积	0.135	0.047	8.377	<0.05	1.145	1.045	1.254
常数	9.492	2.615	13.174	<0.05	-	-	-

自变量	β	SE	Wald	P值	OR	95% CI
自变量	β	SE	Wald	P值	OR	下限	上限
eGFR	-0.024	0.011	5.009	<0.05	0.977	0.956	0.997
GCS评分	-1.302	0.271	23.132	<0.001	0.272	0.160	0.462
出血累及岛叶区域	1.373	0.634	4.690	<0.05	3.948	1.139	13.679
血肿体积	0.135	0.047	8.377	<0.05	1.145	1.045	1.254
常数	9.492	2.615	13.174	<0.05	-	-	-

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