To compare the effects of laparoscopic surgery, interventional embolization and open surgery on coagulation function, arterial blood flow and inflammatory response in patients with ectopic pregnancy rupture.

Ninety nine patients with rupture of ectopic pregnancy admitted to Yulin first hospital from January 2021 to January 2025 were selected; The average age was (31.18±7.82) years, ranging from 28 to 51 years. According to the random number table, the patients were randomly divided into laparoscopic group, interventional embolization group and open surgery group, with 33 cases in each group. Coagulation function indexes [prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT), fibrinogen (FIB)], arterial blood flow indicators [resistance index (RI), pulsatility index (PI), systolic/diastolic ratio (S/D)], and serological indicators [tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), thromboxane A2 (TXA2), cyclooxygenase-2 (COX-2)] were detected before and 48 h after surgery, and the occurrence of adverse pregnancy outcomes was recorded.

At 48 h after operation, the prothrombin time, coagulation time, activated partial thromboplastin time levels in the laparoscopic group were lower than those in the interventional embolization group and the open surgery group, and the fibrinogen level was higher than the other two groups.The levels of RI, PI, S/D, TNF-α, IL-6, TXA2, and COX-2 in the laparoscopic group were lower than those in the other two groups; The incidence of adverse pregnancy outcomes in the laparoscopic group was significantly lower than that in the other two groups(P<0.05).

Laparoscopic surgery for ruptured ectopic pregnancy can better maintain coagulation function, preserve hemodynamic stability, reduce inflammatory response, and lower the incidence of adverse pregnancy outcomes.