To explore the early diagnostic value of soluble growth stimulation expressed gene 2 (sST2) and cardiac troponin I (cTnI) combined with bedside echocardiography for sepsis-induced myocardial depression.

100 sepsis patients admitted to Xiaogan Central Hospital from January 2022 to December 2024 were selected as the research subjects, including 59 males and 41 females, aged 32-70 years [(53.59±4.18) years]. According to the occurrence of myocardial depression, they were divided into a myocardial depression group [(LVEF≤50%) (n=34)] and a non-myocardial depression group [(LVEF>50%) (n=66)]. According to the final prognosis, they were divided into a survival group (n=88) and death group (n=12). All patients underwent serum sST2, cTnI levels measurement and bedside echocardiography examination to analyze the changes in serum sST2, cTnI levels and bedside echocardiography [left ventricular posterior wall thickness in diastole (LVPWd), left ventricular posterior wall thickness in systole (LVPWs)], and to analyze their early diagnostic value using receiver operating characteristic (ROC) curves.

Serum levels of sST2 and cTnI in the myocardial inhibition group were significantly higher than those in the non-myocardial inhibition group (P<0.05); LVPWd and LVPWs levels in the myocardial depression group were significantly higher than those in the non-myocardial depression group, while left atrial stroke volume (LASV), left atrial dilation index (LAEI), and left atrial ejection fraction (LAEF) levels were significantly lower than those in the non-myocardial suppression group (P<0.05). Serum sST2, cTnI, LVPWd, and LVPWs levels in the survival group were significantly lower than those in the death group, while LASV, LAEI, and LAEF levels in the survival group were significantly higher than those in the death group (P<0.05). ROC curve analysis results showed that serum sST2 and cTnI combined with bedside echocardiography has certain diagnostic value for sepsis-induced myocardial depression, and the area under the curve (AUC) of the combined detection was 0.991, with a sensitivity of 93.60% and a specificity of 97.52%.

sST2 and cTnI combined with bedside echocardiography can improve the diagnostic efficacy of sepsis-induced myocardial depression patients.