To explore the perioperative risk and treatment methods of HIV-infected patients with hemophilia.

We detected immune function of 22 HIV-infected patients with hemophilia A (all male, aged 20-54 years old), regulated the operative procedures and operated carefully in order to avoid surgical injury. We also supplemented coagulationⅧ factor, used antibiotics to control infections, and managed complications timely.

There was no intraoperative and postoperative abnormal bleeding in 20 patients. One patient had turbulent bleeding during the surgical removal of the gallbladder. Damage control technology was used to stop the bleeding. Another one patient developed hemorrhagic shock 10 days after operation because of small blood vessel rupture. We transfused blood and supplemented coagulation factors to stop the blooding. All 5 patients with clean wound healed. Two of twelve patients with contaminated wound developed surgical site infections. Four of five patients with dirty wound developed surgical site infections. 9 patients developed sepsis after surgery. Six of the nine patients got infections or sepsis before surgery. There was nobody dead after surgery. All patients were followed up for more than 6 months, and they were all in good condition.

Preoperative infection, intraoperative and postoperative abnormal bleeding are the main reasons of postoperative sepsis for those patients. Using appropriate perioperative treatment for HIV-infected patients with hemophilia can achieve effective results.