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Chinese Journal of Hygiene Rescue(Electronic Edition) ›› 2022, Vol. 08 ›› Issue (03): 134-140. doi: 10.3877/cma.j.issn.2095-9133.2022.03.002

• Original Article • Previous Articles     Next Articles

Correlation between systemic oxidative stress and cardiac function in patients with Takotsubo syndrome

Chunlei Qi1, Chuanqing Weng1, Niannian Liu1, Xinchun Wang1, Junwei Su1, Pingxi Xiao1,()   

  1. 1. Department of Cardiology, the Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, China
  • Received:2022-01-18 Online:2022-06-18 Published:2022-08-05
  • Contact: Pingxi Xiao

Abstract:

Objective

Takotsubo syndrome(TS)is classed as a kind of acute cardiac syndrome with a high incidence of major cardiac events. TS is easy to be misdiagnosed due to the initial clinical presentation and laboratory examination which are similar to acute coronary syndrome(ACS). This study aimed to explore the relationship between systemic oxidative stress and TS through clinical research.

Methods

A total of 12 inpatients with TS as the first diagnosis were collected, while AMI patients and the healthy people examined with matching conditions were both included in the controls. Demographic data were recorded, as well as cardiac function was evaluated by ultrasound.At the same time, we detected the levels of plasma MDA and inflammatory factors in the three groups.

Results

It was found out in clinical trials that the production of plasma MDA in TS patients showed a significant increase.In the meantime, the level of inflammatory cells and the inflammatory factors were elevated.

Conclusions

The level of system oxidative stress increases and the inflammation is activated in TS patients.

Key words: Takotsubo syndrome, Acute myocardial infarction, MDA, Oxidative stress

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