Effects of Hypertonic Sodium Chloride Hydroxyethyl Starch 40 injection on coagulation function and Ca2+ change of traumatic shock rabbit

doi:10.3877/cma.j.issn.2095-9133.2015.03.010

Abstract

Abstract:

Objective

Effect of limited fluid resuscitation on blood coagulation function and Ca²⁺change in traumatic shock rabbits.

Methods

54 healthy rabbits in total were divided into Normal Saline（NS） group，Hypertonic Sodium Chloride Hydroxyethyl Starch 40（HHS） group and 2 time Normal Saline+1 time Hydroxyethyl Starch 40（NHS） group randomly with 18 in every group.PT，APTT，Fbg，TT，INR and Ca²⁺change at various time points were compared and studied in the group and between the different groups.

Result

Three groups of liquid recovery after PT compared with T₀ time P＜0.05，the difference was statistically significant； Three groups of liquid recovery after APTT compared with T₀ time P＜0.05，the difference was statistically significant； Three groups of liquid recovery after Fbg in T₁，T₂，T₃ time compared with T₀ time all P＜0.05，the difference was statistically significant；Compared with NS and NHS，HHS can obviously improve the PT，APTT and Fbg levels，the difference was statistically significant（P＜0.05）.

Conclusion

Hypertonic Sodium Chloride Hydroxyethyl Starch 40 injection can improve low perfusion and blood coagulation function obviously.

Key words: Hypertonic Sodium Chloride Hydroxyethyl Starch 40 injection, Coagulation function, Ca²⁺, Limited fluid resuscitation

Bianhua Liu, Guotao Wang, Sisen Zhang, Qing Liu, Shupeng Han. Effects of Hypertonic Sodium Chloride Hydroxyethyl Starch 40 injection on coagulation function and Ca²⁺ change of traumatic shock rabbit[J]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2015, 01(03): 33-36.

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Figures/Tables 3

References 10

1	Ganter MT，Pittet JF.New insights into acute coagulopathy in trauma patients［J］.Best Pract Res Clin Anaesthesiol，2010，24（1）：15-25.
2	Johansson PI，Stensballe J，Rasmussen LS，et al.A high admission syndecan-1 level，a marker of endothelial glycocalyx degradation，is associated with inflammation，protein C depletion，fibrinolysis，and increased mortality in trauma patients［J］.Ann Surg，2011，254（2）：194-200.
3	Frith D，Goslings JC，Gaarder C，et al.Definition and drivers of acute traumatic coagulopathy：clinical and experimental investigations［J］.JThromb Haemost，2010，8（9）：1919-1925.
4	Floccard B，Rugeri L，Faure A，et al.Early coagulopathy in trauma patients：an on-scene and hospital admission study［J］.Injury，2012，43（1）：26-32.
5	Frith D，Davenport R，Brohi K.Acute traumatic coagulopathy［J］.Curr Opin Anaesthesiol，2012，25（2）：229-234.
6	Schmidt-Hieber M，Loddenkemper C，Schwartz S，et al.Hydrops lysosomalis generalisatus--an underestimated side effect of hydroxyethyl starch therapy？［J］.Eur J Haematol，2006，77（1）：83-85.
7	Myburgh JA，Finfer S，Bellomo R，et al.Hydroxyethyl starch or saline for fluid resuscitation in intensive care［J］.N Engl JMed，2012，367（20）：1901-1911.
8	Kaspereit F，Doerr B，Dickneite G.The effect of fibrinogen concentrate administration on coagulation abnormalities in a rat sepsis model［J］.Blood Coagul Fibrinolysis，2004，15（1）：39-43.
9	Shitrit D，Izbicki G，Shitrit AB，et al.Prognostic value of a new quantitative D-dimer test in critically ill patients 24 and 48 h following admission to the intensive care unit［J］.Blood Coagul Fibrinolysis，2004，15（1）：15-19.
10	de Jonge E，Dekkers PE，Creasey AA，et al.Tissue factor pathway inhibitor dose-dependently inhibits coagulation activation without influencing the fibrinolytic and cytokine response during human endotoxemia［J］.Blood，2000，95（4）：1124-1129.

组别及时间	PT	APTT
NS
T₀	9.18±0.52	59.71±18.96
T1	10.94±0.82^ac	51.99±4.6^c
T₂	13.83±0.66^ac	49.2±7.1^c
T₃	19.19±1.19^ac	55.37±14.27^ac
HHS
T₀	9.15±1.81	59.62±46.76
T₁	9.31±1.15^c	52.32±30.2^c
T₂	10.28±3.47^c	49.75±30.96^c
T₃	10.04±2.41^c	38.5±18.25^c
NHS
T₀	9.16±0.93	59.13±37.9
T₁	11.86±2.32^ab	59.91±41.53^cb
T₂	14.5±3.65^ac	68.61±47.26^cb
T₃	17.9±3.77^ac	114.42±66.82^cab

组别及时间	PT	APTT
NS
T₀	9.18±0.52	59.71±18.96
T1	10.94±0.82^ac	51.99±4.6^c
T₂	13.83±0.66^ac	49.2±7.1^c
T₃	19.19±1.19^ac	55.37±14.27^ac
HHS
T₀	9.15±1.81	59.62±46.76
T₁	9.31±1.15^c	52.32±30.2^c
T₂	10.28±3.47^c	49.75±30.96^c
T₃	10.04±2.41^c	38.5±18.25^c
NHS
T₀	9.16±0.93	59.13±37.9
T₁	11.86±2.32^ab	59.91±41.53^cb
T₂	14.5±3.65^ac	68.61±47.26^cb
T₃	17.9±3.77^ac	114.42±66.82^cab

组别及时间	Fbg（g/L）	TT（s）
NS
T₀	2.63±0.26	35.17±17.07
T₁	2.26±0.41^c	22.89±2.34
T₂	1.52±0.46^ca	21.99±3.5
T₃	1.48±0.44^ca	20.65±3.21
HHS
T₀	2.68±0.68	35.13±39.74
T₁	2.48±0.47^c	26.51±7.21
T₂	2.34±0.57^c	27.11±13.84^c
T₃	2.11±0.62^c	26.62±11.52
NHS
T₀	2.62±0.27	34.56±8.88
T₁	1.94±0.29^c	37.33±12.99^c
T₂	1.75±0.32^ca	27.41±5.93
T₃	1.48±0.24^ca	26.21±4.9

组别及时间	Fbg（g/L）	TT（s）
NS
T₀	2.63±0.26	35.17±17.07
T₁	2.26±0.41^c	22.89±2.34
T₂	1.52±0.46^ca	21.99±3.5
T₃	1.48±0.44^ca	20.65±3.21
HHS
T₀	2.68±0.68	35.13±39.74
T₁	2.48±0.47^c	26.51±7.21
T₂	2.34±0.57^c	27.11±13.84^c
T₃	2.11±0.62^c	26.62±11.52
NHS
T₀	2.62±0.27	34.56±8.88
T₁	1.94±0.29^c	37.33±12.99^c
T₂	1.75±0.32^ca	27.41±5.93
T₃	1.48±0.24^ca	26.21±4.9

组别及时间	Ca²⁺	INR
NS
T₀	2.7±0.25	0.83±0.06
T₁	2.55±0.16^c	0.74±0.07^c
T2	2.41±0.12^c	0.88±0.3^c
T3	2.34±0.17^c	0.69±0.14^ac
HHS
T0	2.69±0.55	0.87±0.15
T1	2.26±0.61^c	0.82±0.18^c
T2	2.3±0.5^c	0.88±0.3^c
T3	2.25±0.51^c	0.88±0.24^c
NHS
T0	2.71±0.19	0.82±0.13
T1	2.62±0.11^ca	0.94±0.20^b
T2	2.36±0.23^c	0.87±0.12^c
T3	2.15±0.24^c	0.92±0.19^cb

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