Abstract:
Objective To investigate the clinical significance of procalcitonin(PCT), N-terminal precursor natriuretic peptide (NT-pro-BNP), lactic acid(Lac)in sepsis patients of ICU and the value of prognosis evaluation of them.
Methods Total 70 cases of sepsis patients were collected in the Department of Critical Care Medicine of our hospital between April 2016 and April 2018(observation group); at the same time 30 cases of healthy physical examination were enrolled(control group). Venous blood was extracted from sepsis patients to detect PCT, NT-pro-BNP and LAC when they entered ICU, and fasting venous blood was extracted from the control group to detect PCT, NT-pro-BNP and LAC, and the differences between the two groups were compared. The observation group was divided into survival group and death group. The differences of PCT, NT-pro-BNP and LAC were compared between the two groups. Spearman test was used for correlation analysis of PCT, NT-pro-BNP and LAC in patients with survival and mortality. ROC curve was used to evaluate the value of PCT, NT-pro-BNP and LAC in the prognosis of sepsis patients.
Results PCT, NT-pro-BNP and LAC in the observation group were (23.00±27.60)ng/L, (7 665.50±8 084.83)ng/L and (4.59±3.47)mg/L, respectively, higher than the control group (P<0.05). PCT, NT-pro-BNP and LAC were (45.65±30.64)ng/L, (9 950.21±7 118.21)ng/L and (6.79±3.00)mg/L respectively in the death group, higher than that in the survival group (P<0.05). Spearman correlation analysis showed that PCT, NT-pro-BNP and LAC were negatively correlated with the survival outcome of patients, with r being -0.597, -0.323 and -0.505, respectively (P<0.05). The ROC curve showed that the cutoff value of PCT was 12.25 ng/L, the sensitivity was 0.998, and the specificity was 0.698; the cutoff value of NT-pro-BNP was 2 372.50 ng/L, the sensitivity was 0.963, and the specificity was 0.488; the cutoff value of LAC was 2.8 mg/L, the sensitivity was 0.999, and the specificity was 0.628.
Conclusion PCT, NT-pro-BNP and LAC in sepsis patients are significantly increased, and combined detection of PCT, nt-pro-bnp and LAC have a certain value in prognostic evaluation of sepsis patients.
Key words:
Sepsis,
Procalcitonin,
N-terminal precursor natriuretic peptide,
Lactic acid,
Prognosis
Zhen Wang, Guomin Li, Shuangxian Guan, Dong Yuan. Prognostic value of procalcitonin, N-terminal precursor natriuretic peptide and lactic acid in sepsis patients of the Department of Critical Care Medicine[J]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2020, 06(05): 284-287.