To observe the clinical effect of Qianjinweijing decoction combined with Xuebijing injection on patients with severe pneumonia (SP).

Seventy-two patients with SP were enrolled in our hospital, including 38 males and 34 females, aged from 32 to 70 years, with an average age of (45.74±7.79) years. The patients were divided into Xuebijing group (36 cases) and comprehensive group (36 cases). Xuebijing group was treated with Xuebijing Injection on the basis of routine intervention, while comprehensive group was treated with Qianjinweijing Decoction on the basis of Xuebijing group. Both groups were intervened for 7 days. The changes of TCM syndrome score, C-reactive protein (CRP), procalcitonin (PCT) and arterial blood gas(PaO₂, PaCO₂ levels) were observed before and after treatment.

There was no statistical difference between the two groups in TCM syndrome score, CRP and PCT before treatment (P>0.05). After treatment, the score of TCM symptom in Xuebijing group decreased from (25.83±5.74) to (16.82±4.37), and CRP decreased from (122.75±10.12) mg/L to (51.46±6.42) mg/L, PCT decreased from (0.58±0.20) ng/mL to (0.27±0.12) ng/mL, the level of PaO₂ increased from (44.36±6.21) mmHg to (68.61±5.74) mmHg, and the level of PaCO₂ decreased from (67.89±5.82) to (48.83±4.61) mmHg before treatment. The scores of TCM symptom in the combined group decreased from (25.27±6.12) to (12.38±4.16) , CRP from (123.74±9.75) mg/L to (40.48±5.38) mg/L, PCT from (0.59±0.21) ng/mL to (0.17±0.09) ng/mL, the level of PaO₂ increased from (45.82±6.64) mmHg to (77.63±5.42) mmHg, and the level of PaCO₂ decreased from (66.73±6.02) mmHg before treatment to (38.84±4.12) mmHg before treatment. The TCM syndrome score, CRP, and PCT of the two groups were lower than those before treatment, and the differences were statistically significant (P<0.05); meanwhile, the TCM syndrome score, CRP, and PCT of the comprehensive group were lower than those of the Xuebijing group. The differences were also statistically significant (P<0.05). In terms of arterial blood gas analysis, there was no statistical difference in PaO₂ and PaCO₂ levels between the two groups before treatment (P>0.05). After treatment, the PaO₂ and PaCO₂ levels of the two groups were better than those before the treatment, and the differences were statistically significant (P<0.05). At the same time, the PaO₂ and PaCO₂ levels of the comprehensive group were better than those of Xuebijing group, and the differences were statistically significant (P<0.05).

Qianjinweijing Decoction combined with Xuebijing injection to treat severe pneumonia patients can effectively reduce the level of inflammation, improve the state of lung function and related symptoms. It is worthy of further promotion.