Collecting perioperative coagulation indexes (APTT, PT, FIB, DD and PLT) from patients with extra-severe burns and analyzing the effect of sedation compound anesthesia on patients’ coagulation function and its clinical significance.

In the past three years, 148 patients with severe burns admitted to the Burn Surgery Department of the Third Affiliated Hospital of Inner Mongolia Medical University were selected. They were divided into the survival group [129 males, 9 females; age 24-59 years, mean (43.30±12.90) years] and the death group [8 male cases, 2 female cases; age 26-63 years, mean (46.19±15.41) years]. The coagulation markers were recorded within 7 days after injury. The dynamic differences of coagulation markers were compared between the survival group and the death group.

The amount of fluid infusion, cumulative plasma and red blood cell input in the shock period of the death group was significantly higher than that of the survival group (P<0.01), the difference was statistically significant. At T0, the FIB of the surviving group (1.78±0.32) was significantly higher than that of the dead group (1.26±0.07) (P<0.05); at T2, APTT and PT were significantly shorter in both groups (P<0.05), and the FIB of the surviving group (3.86±0.40) was significantly higher than that of the dead group (2.45±1.02) (P<0.05); at T3, the death group PLT was significantly lower than that of the surviving group (P<0.01).

Patients with extra-severe burns are prone to a hypercoagulable state in the perioperative period, which can lead to death. Intravenous compound anesthesia and perioperative resuscitation with large amounts of fluids can promote a hypercoagulable state in patients.