To investigate whether the level of arterial blood lactic acid is related to the prognosis of patients with hemorrhagic fever with renal syndrome(HFRS).

A total of 41 patients with HFRS admitted to the Sun Yat-sen Memorial Hospital from January 2014 to December 2018 were retrospectively analyzed, including 33 males (80.5%) and 8 females (19.5%), aged from 19 to 73 years, with an average of (44.2±14.0) years old. The patients were divided into groups according to the recovery time of renal function. 22 cases in group A were defined as rapid recovery group (≤12 days), 11 cases in group B as slow recovery group (>12 days), and 8 cases in group C as non recovery group. The symptom characteristics, laboratory examination, treatment recovery time and prognosis were collected and statistically analyzed. According to the level of arterial blood lactate, the patients were divided into normal lactate group and elevated lactate group. The average recovery time of renal function, the proportion of blood purification treatment and the mortality of the two groups were compared.

Among 41 patients with hemorrhagic fever with renal syndrome, renal function recovered in 33 cases (80.5%). The median time of renal function recovery was 12 days. 8 cases (19.5%) were treated with hemodialysis and 2 cases(4.9%)died. The average recovery time of renal function in the elevated lactic acid group was longer, the proportion of CRRT treatment was higher and the mortality was higher.

The increase of arterial bloodlactic acid level may predict the poor prognosis of patients with hemorrhagic fever with renal syndrome.