To investigate the relationship between IL-2, IL-4, IL-10, immunefunction indexes and their predictive value for prognosis.

A total of 57 patients with sepsis admitted to Zhengzhou People’s Hospital from January 2020 to December 2021 were selected, including 29 males and 28 females, aged 41-97 years, with an average of 78 years.According to the presence or absence of septic shock, they were divided into a sepsis group and a septic shock group. The levels of IL-2, IL-4, IL-10, APACHEⅡ(acute physiology and chronic health score) and sequential organ failure score (SOFA) were recorded, the relationship between each index and immune function was analyzedwith comparison with patients’ prognosisand evaluation of its predictive value.

The levels of IL-2, IL-4 and IL-10 in the septic shock group were higher than those in the sepsis group, while the levels of CD4⁺ , CD8⁺ and CD4⁺ /CD8⁺ were lower than those in the sepsis group, and the differences were statistically significant (P<0.05); IL-2, IL-4 and IL-10 were negatively correlated with CD4⁺ and CD8⁺ (P<0.05), but had not correlated with CD4⁺ /CD8⁺ (P>0.05), Results The levels of IL-2, IL-4andIL-10 in the septic shock group were higher than those in the sepsis group, while the levels of CD4⁺ , CD8⁺ , CD4⁺ /CD8⁺ were lower than those in the sepsis group, and the differences were statistically significant (P<0.05); IL-2, IL-4, IL-10 were negatively correlated with CD4⁺ and CD8⁺ (P<0.0), but had no correlation with CD4⁺ /CD8⁺ (P>0.05). The receiver operating characteristic (ROC) curve display values of L-2, IL-4, IL-10 levels and 28-day prognosis of sepsis patients were 0.744, 0.698and 0.871, respectively.

High levels of inflammatory factors in patients with sepsis are associated with low immune function. The elevations of IL-2, IL-4 and IL-10 have good predictive value for the poor prognosis of patients with sepsis.