Value of serum cytokines in predicting pneumonia secondary to acute cerebral infarction

doi:10.3877/cma.j.issn.2095-9133.2024.01.004

Abstract

Abstract:

Objective

To investigate the correlation between serum cytokines and pneumonia secondary to acute cerebral infarction (ACI) .

Methods

99 patients with acute cerebral infarction admitted to the Neurology Intensive Care Unit of Dongfang Hospital Affiliated to Tongji University were selected as the study subjects, including 70 males (70.71%) and 29 females (29.29%); The age range is from 27 to 95 years old, with an average of (67±13) years old. Within 48 hours of onset, serum concentrations of twelve cytokines, including interleukin-1, were detected β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12P70, IL-17A, interferon (IFN)-α, IFN- γ, Tumor necrosis factor (TNF)-α And serum albumin, globulin, peripheral blood leukocyte count, peripheral blood lymphocyte count; According to whether the research subjects developed pneumonia afterwards, they were divided into pneumonia group (44 cases) and non pneumonia group (55 cases). Binary logistic regression analysis was used to determine whether the twelve cytokines were independent predictors of pneumonia after acute cerebral infarction.

Results

Binary logistic regression analysis showed that the increased serum IL-10 (OR 1.24, 95% CI 1.01-1.52, P=0.039) and increased peripheral blood WBC counts (OR 1.50, 95% CI 1.18-1.92, P=0.001) were independent predictors for ACI secondary pneumonia. To predict ACI secondary pneumonia, the sensitivity and specificity of serum IL-10>2.50 ng/L within 48 hours of ACI, were 61.36% and 64.29%; the sensitivity and specificity of peripheral blood WBC counts>10.00×10⁹/L within 48 hours of ACI, were 50.00% and 81.48%; the sensitivity and specificity of the combination of the two were 34.09% and 83.33%, respectively.

Conclusion

At the early stage of ACI, increased serum IL-10 and peripheral blood WBC counts have a certain diagnostic value for ACI secondary pneumonia, with high specificity but low sensitivity.

Key words: Acute cerebral infarction, Pneumonia, Cytokines, Interleukin, White blood cells

Chaotao Nan, Jian Chen, Shuhong Wang, Gang Li, Junjie Hao. Value of serum cytokines in predicting pneumonia secondary to acute cerebral infarction[J]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2024, 10(01): 16-20.

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References 15

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组别	例数	年龄（岁）	男性[例（%）]	IL-1β	IL-2	IL-4
肺炎组	44	71（65，78）	29（65.91）	2.50（2.50，2.50）	2.50（2.50，2.50）	2.50（2.50，2.50）
非肺炎组	55	66（60，71）	41（74.55）	2.50（2.50，2.50）	2.50（2.50，2.50）	2.50（2.50，2.50）
H/χ²值		4.53	0.88	0.19	0.32	0.27
P值		<0.05	>0.05	>0.05	>0.05	>0.05

组别	例数	年龄（岁）	男性[例（%）]	IL-1β	IL-2	IL-4
肺炎组	44	71（65，78）	29（65.91）	2.50（2.50，2.50）	2.50（2.50，2.50）	2.50（2.50，2.50）
非肺炎组	55	66（60，71）	41（74.55）	2.50（2.50，2.50）	2.50（2.50，2.50）	2.50（2.50，2.50）
H/χ²值		4.53	0.88	0.19	0.32	0.27
P值		<0.05	>0.05	>0.05	>0.05	>0.05

组别	例数	IL-5	IL-6	IL-8	IL-10	IL-12P70
肺炎组	44	2.50（2.50，2.50）	48.38（23.22，158.34）^*	71.99（39.33，120.72）^*	4.00（2.50，7.57）^*	2.50（2.50，2.50）
非肺炎组	55	2.50（2.50，2.50）	12.06（4.94，31.27）^*	64.50（34.25，216.12）^*	2.50（2.50，2.79）	2.50（2.50，2.50）
H值		0.08	20.33	0.33	14.78	0.40
P值		>0.05	<0.05	>0.05	<0.05	>0.05

组别	例数	IL-5	IL-6	IL-8	IL-10	IL-12P70
肺炎组	44	2.50（2.50，2.50）	48.38（23.22，158.34）^*	71.99（39.33，120.72）^*	4.00（2.50，7.57）^*	2.50（2.50，2.50）
非肺炎组	55	2.50（2.50，2.50）	12.06（4.94，31.27）^*	64.50（34.25，216.12）^*	2.50（2.50，2.79）	2.50（2.50，2.50）
H值		0.08	20.33	0.33	14.78	0.40
P值		>0.05	<0.05	>0.05	<0.05	>0.05

组别	例数	IL-17A	IFN-α	IFN-γ	TNF-α
肺炎组	44	2.50（2.50，2.50）	2.50（2.50，2.50）	2.50（2.50，2.50）	2.50（2.50，2.50）
非肺炎组	55	2.50（2.50，2.50）	2.50（2.50，2.50）	2.50（2.50，2.50）	2.50（2.50，2.50）
H值		0.41	0.14	2.01	0.17
P值		>0.05	>0.05	>0.05	>0.05

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