Application of pre-hospital mild hypothermia combined with thrombolysis in treatment of acute cerebral infarction

doi:10.3877/cma.j.issn.2095-9133.2024.03.003

Abstract

Abstract:

Objective

To investigate the effect of mild hypothermia therapy combined with intravenous thrombolysis in the treatment of patients with acute cerebral infarction (ACI) from pre-hospital.

Methods

From January 2022 to June 2023, Zhenjiang Emergency Center sent patients who were initially diagnosed as stroke to the hospital for treatment at the pre-hospital emergency site. Finally, 78 patients who were diagnosed as acute cerebral infarction were randomly divided into observation group (38 cases) and control group (40 cases). The patients in the control group received routine pre-hospital emergency measures, and the patients in the observation group began to implement mild hypothermia treatment before the hospital. The patients in the two groups were treated with alteplase intravenous thrombolysis after reaching the hospital. The National Institutes of Health Stroke Scale (NIHSS) score, activities of daily living scale (ADL), superoxide dismutase (SOD) and malondialdehyde (MDA) levels were compared between the two groups.

Results

After 2 weeks of treatment, the NIHSS score, ADL score, SOD level and MDA level in the observation group were better than those in the control group, and the differences were statistically significant (all P<0.05).

Conclusion

Pre-hospital mild hypothermia therapy combined with intravenous thrombolysis significantly reduces the oxidative stress response and improves the prognosis for patients with acute cerebral infarction.

Key words: Mild hypothermia, Intravenous thrombolysis, Alteplase, Acute cerebral infarction, Neurological function

Xin Pan, Xiaoyun Huang, Chao Wang, Hui Gu, Jiabo Tang, Peng Wang, Hengxi Cui, Zheng Li. Application of pre-hospital mild hypothermia combined with thrombolysis in treatment of acute cerebral infarction[J]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2024, 10(03): 145-148.

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References 21

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组别	例数	MDA（mmol/L）		SOD（U/L）
组别	例数	溶栓前	溶栓后7 d	溶栓前	溶栓后7 d
对照组	40	9.14±0.66	7.20±0.56	90.54±0.32	109.84±2.74
观察组	38	9.07±0.70	6.91±0.58	90.49±0.33	114.71±2.40
t值		0.45	2.28	0.76	-8.33
P值		>0.05	<0.05	>0.05	<0.05

组别	例数	MDA（mmol/L）		SOD（U/L）
组别	例数	溶栓前	溶栓后7 d	溶栓前	溶栓后7 d
对照组	40	9.14±0.66	7.20±0.56	90.54±0.32	109.84±2.74
观察组	38	9.07±0.70	6.91±0.58	90.49±0.33	114.71±2.40
t值		0.45	2.28	0.76	-8.33
P值		>0.05	<0.05	>0.05	<0.05

组别	例数	溶栓前	溶栓后时间（d）
组别	例数	溶栓前	1 d	3 d	7 d	14 d
对照组	40	15.89±0.65	10.90±0.61	9.40±0.89	6.95±0.64	6.08±0.65
观察组	38	15.58±0.92	10.38±1.38	8.49±1.33	6.34±1.33	5.57±1.34
t值		1.71	2.13	3.53	2.56	2.12
P值		>0.05	<0.05	<0.05	<0.05	<0.05

组别	例数	溶栓前	溶栓后时间（d）
组别	例数	溶栓前	1 d	3 d	7 d	14 d
对照组	40	15.89±0.65	10.90±0.61	9.40±0.89	6.95±0.64	6.08±0.65
观察组	38	15.58±0.92	10.38±1.38	8.49±1.33	6.34±1.33	5.57±1.34
t值		1.71	2.13	3.53	2.56	2.12
P值		>0.05	<0.05	<0.05	<0.05	<0.05

组别	例数	ADL溶栓前	溶栓后时间（d）
组别	例数	ADL溶栓前	1 d	3 d	7 d	14 d
对照组	40	22.90±0.56	47.65±1.56	70.03±1.57	75.82±1.86	80.40±1.41
观察组	38	23.11±0.57	48.91±1.44	71.15±1.78	76.78±1.76	81.09±1.59
t值		-1.64	-3.71	-2.95	-2.34	-2.03
P值		>0.05	<0.05	<0.05	<0.05	<0.05

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