Correlation between serum Hcy, Cys-C, UA, lipoprotein a levels and myocardial injury severity in patients with acute myocardial infarction

doi:10.3877/cma.j.issn.2095-9133.2025.06.001

Abstract

Abstract:

Objective

To study the serum levels of homocysteine (Hcy), cystatin C (Cys-C), uric acid (UA) and lipoprotein a in patients with acute myocardial infarction and to explore the correlation of their changes with the degree of myocardial injury.

Methods

A retrospective study was conducted on 150 patients with AMI admitted to Shuyang Hospital from January 2022 to December 2023, designated as the AMI group. Additionally, 120 healthy individuals who underwent physical examinations at Shuyang Hospital during the same period were selected as the control group. The levels of serum Hcy, Cys-C, UA, and lipoprotein a were measured and analyzed, and the relationship between changes in these indicators and the degree of myocardial injury was investigated.

Results

The levels of serum Hcy, Cys-C, UA, and lipoprotein a in the case group were significantly higher than those in the control group, and the difference was statistically significant (P<0.05). The levels of serum Hcy, Cys-C, UA, and lipoprotein a in patients with severe myocardial injury were significantly higher than those in patients with mild myocardial injury, and the differences were statistically significant (P<0.05). The correlation analysis results showed that serum Hcy, Cys-C, UA, and lipoprotein a in AMI patients were positively correlated with the degree of myocardial injury (r=0.513, 0.448, 0.399, 0.519, P<0.05).

Conclusion

As the degree of myocardial injury increases, the level of serum Hcy, Cys-C, UA, and lipoprotein a is significantly elevated, which may synergistically participate in the occurrence and development of acute myocardial infarction.

Key words: Acute myocardial infarction, Homocysteine, Cystatin C, Uric acid, Lipoprotein a, Myocardial injury, correlation

Shuang Zhou, Dongdong Cai, Min Hu. Correlation between serum Hcy, Cys-C, UA, lipoprotein a levels and myocardial injury severity in patients with acute myocardial infarction[J]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2025, 11(06): 321-324.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhwsyjdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-9133.2025.06.001

https://zhwsyjdzzz.cma-cmc.com.cn/EN/Y2025/V11/I06/321

Figures/Tables 3

References 19

[1]	邵明学,李小波,张辛颖,等.青年初发急性心肌梗死患者的临床特征及危险因素分析[J].现代生物医学进展, 2023, 23(14): 2791-2795.
[2]	孙维忆,邢欣,卞晓华,等.急诊科急性心肌梗死患者临床特征分析[J].中国临床医生杂志, 2023, 51(5): 577-581.
[3]	赵曼云,郭蔚虹,张霞.血清和肽素、脂蛋白(a)水平预测急性心肌梗死病人短期预后的临床价值[J].中西医结合心脑血管病杂志, 2022, 20(12): 2249-2252.
[4]	王璐,金烨,陈奕纬. NT-pro BNP、Hcy及Apo-A与急性心肌梗死患者心力衰竭程度及预后的相关性[J].中国医药导刊, 2024, 26(4): 401-406.
[5]	中华医学会心血管病学分会,中华心血管病杂志编辑委员会.急性ST段抬高型心肌梗死诊断和治疗指南(2019)[J].中华心血管病杂志, 2019, 47(10): 766-783.
[6]	顾君,蔡高军.经皮冠状动脉介入治疗184例ST段抬高性急性心肌梗死患者临床特征分析[J/CD].中华卫生应急电子杂志, 2020, 6(3): 142-147.
[7]	Gulati R, Behfar A, Narula J, et al. Acute myocardial infarction in young individuals[J]. Mayo Clin Proc. 2020, 95(1): 136-156.
[8]	廖伟亮,赖娜婷,陈文明,等.急性ST段抬高型心肌梗死患者心电图QRS延长与心肌损伤的相关性[J/CD].中华卫生应急电子杂志, 2020, 6(4): 220-223.
[9]	汪彪,陈见红,吴刚,等.外周血miR-30a miR-24及Sestrin2表达与急性心肌梗死患者心肌损伤程度的相关性[J].河北医学, 2023, 29(11): 1821-1826.
[10]	李雨浓,韦伟,周音频.急性心肌梗死患者血浆miR-542-5p表达水平与心肌损伤程度的相关性分析[J].中国循证心血管医学杂志, 2022, 14(7): 865-868.
[11]	Kapur NK, Thayer KL, Zweck E. Cardiogenic shock in the setting of acute myocardial infarction[J]. MethodistDebakey Cardiovasc J, 2020, 16(1): 16-21.
[12]	杨蓉,刘裴,张小琳,等.血清Omentin-1、HCY水平对急性心肌梗死患者心室重构及预后的预测价值[J].山东医药, 2020, 60(31): 32-36.
[13]	寇翰林,张贺平,李洪娟,等.急性心肌梗死患者cTNT、CYS-C、CREA变化规律的研究[J].中国实验诊断学, 2022, 26(3): 366-368.
[14]	Femia G, French JK, Juergens C, et al. Right ventricular myocardial infarction: pathophysiology, clinical implications and management[J]. Rev Cardiovasc Med, 2021, 22(4): 1229-1240.
[15]	孙莹莹,常丽辉,苗文霞.老年急性ST段抬高型心肌梗死患者血清RF, Cys-C水平与直接PCI术后无复流的关系[J].现代检验医学杂志, 2022, 37(2): 184-189.
[16]	刘晓晨,杨威.急性心肌梗死患者血清尿酸、转化生长因子β1、糖类抗原12-5的表达水平及其联合预测新发房颤的价值[J].广西医学, 2022, 44(16): 1831-1835.
[17]	万俊,徐凤,王育林,等.急性心肌梗死患者血清血清脂蛋白a、血清钙卫蛋白A4、血小板活化物表达水平及对心脏不良事件的影响[J].实用医学杂志, 2022, 38(8): 929-933.
[18]	伦柱斌,叶健烽.老年急性心肌梗死患者蛋白表达与心肌纤维化和心肌损伤的关系[J].中华老年心脑血管病杂志, 2024, 26(5): 499-503.
[19]	王玮,张林叶,刘冉.血清Hcy、Cys-C水平与急性心肌梗死患者冠脉病变程度及预后的关系研究[J].湖南师范大学学报(医学版), 2022, 19(1): 206-210.

组别	例数	Hcy（μmol/L）	Cys-C（mg/L）	UA（mmol/L）	脂蛋白a（mg/L）
AMI组	150	19.25±3.81	1.24±0.23	386.49±101.18	307.14±56.67
对照组	120	15.51±4.20	0.86±0.14	321.45±89.43	135.61±19.78
t值		7.66	15.89	5.52	31.64
P值		<0.001	<0.001	<0.001	<0.001

组别	例数	Hcy（μmol/L）	Cys-C（mg/L）	UA（mmol/L）	脂蛋白a（mg/L）
AMI组	150	19.25±3.81	1.24±0.23	386.49±101.18	307.14±56.67
对照组	120	15.51±4.20	0.86±0.14	321.45±89.43	135.61±19.78
t值		7.66	15.89	5.52	31.64
P值		<0.001	<0.001	<0.001	<0.001

心肌损伤情况	例数	Hcy（μmol/L）	Cys-C（mg/L）	UA（mmol/L）	脂蛋白a（mg/L）
轻度损伤	63	17.06±2.83	1.04±0.18	350.58±88.68	223.43±55.68
重度损伤	87	20.84±3.16	1.38±0.21	412.49±90.78	367.76±58.87
t值		7.55	10.38	4.16	15.16
P值		<0.001	<0.001	<0.001	<0.001

心肌损伤情况	例数	Hcy（μmol/L）	Cys-C（mg/L）	UA（mmol/L）	脂蛋白a（mg/L）
轻度损伤	63	17.06±2.83	1.04±0.18	350.58±88.68	223.43±55.68
重度损伤	87	20.84±3.16	1.38±0.21	412.49±90.78	367.76±58.87
t值		7.55	10.38	4.16	15.16
P值		<0.001	<0.001	<0.001	<0.001

Please choose a citation manager

Content to export