To explore the value of detecting intestinal type fatty acid binding protein (I-FABP), D-lactate, and inflammatory factors in patients with sepsis-related acute gastrointestinal injury.

A retrospective analysis of medical records of 80 sepsis patients admitted to Yan'an People's Hospital from January 2021 to December 2024 was conducted, including 42 males and 38 females. The age ranged from 32 to 70 years, with an average of (53.52±4.10) years. According to the relevant acute gastrointestinal injury situation, the patients were divided into sepsis-related acute gastrointestinal injury group (n=25), sepsis-related non acute gastrointestinal injury group (n=55). According to the final results of acute gastrointestinal injury, they were divided into grade I-II group (n=16) and grade III-IV group (n=9). All patients were tested for serum I-FABP, D-lactate, and inflammatory factors, and the changes in serum I-FABP, D-lactate, and inflammatory factors were analyzed. The receiver operating characteristic (ROC) curve was used to analyze their early diagnostic value.

The levels of serum I-FABP, D-lactate, C-reactive protein (CRP), interleukin-6 (IL-6), and procalcitonin (PCT) in sepsis related acute gastrointestinal injury group were significantly higher than those in sepsis-related non gastrointestinal injury group (P<0.05); The levels of serum I-FABP, D-lactate, CRP, IL-6, and PCT in patients with grade III-IV were significantly higher than those in patients with grade I-II (P<0.05); ROC curve analysis showed that serum I-FABP, D-lactate, and inflammatory factors all had certain diagnostic value for acute gastrointestinal injury related to sepsis patients, and the combined detection AUC was 0.857, sensitivity was 91.34%, and specificity was 94.65%, indicating high diagnostic value.

The combined detection of serum I-FABP, D-lactate and inflammatory factors can improve the diagnostic efficiency of sepsis related acute gastrointestinal injury and can early reflect gastrointestinal tissue damage in patients.