To observe the clinical feasibility of disposable ejection-type intraosseous infusion device in cardiopulmonary resuscitation (CPR).

In the process of clinical rescue of patients with heart and lung resuscitation, 8 bone marrow puncture points were selected from four locations including the upper end of the tibia, the distal radius, the humerus head and sternum. The ejection-type intraosseous infusion device was used together with conventional venous infusion and the relating indicators were observed and analyzed.

Clinical observation was performed in 38 patients (35 in ICU and 3 in orthopedics department), including 24 males and 12 females at age range of 17-78 years. Rescue was failed in 9 patients. Restoration of spontaneous circulation (ROSC) was succeeded in 29 patients including 8 patients with ROSC maintenance within 4 hours and 21 patients with ROSC over 4 hours. Infusion speed free from pressure in upper end of the tibia, the distal radius, the humerus head and sternum was 16.5 mL/min, 7.2 mL/min, 15.0 mL/min and 23.8 mL/min respectively. The infusion speed under pressure could reach 50 mL/min or higher. Time for successful insertion was 15-120 seconds. The operation could be completed within 15-20 seconds for the skilled person and within 60-120 seconds for the unskilled persons. The needle could be retained for 4-6 hours, and no fracture was observed. The intraosseous infusion included plasma, plasma substitutes, normal saline or Ringer′s solution. The success rate of disposable ejection-type intraosseous infusion device was 100% (38/38).

Bone marrow infusion with aid of disposable ejection-type intraosseous infusion device can be used not only in pre-hospital, but also in hospitals or even in ICU, where a fast and reliable fluid resuscitation is required in order to achieve the best effect of resuscitation within "platinum 10 minutes" .