To observe Tongfu Xiele recipe in the treatment of sepsis and its clinical efficacy on procalcitonin (PCT) and immune function.

A total of 60 patients that enrolled in Department of Surgery of Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine were divided into treatment group and control group. Both groups were treated on the basis of conventional Western medicine treatment. Additionally, the treatment group was given 500 mL of Tongfu Xiere recipe and the control group received normal saline enema. The treatment effects were observed in two groups before treatment and at days 3, 7 and 14 after treatment. The changes of blood PCT, T lymphocyte subsets(CD3⁺ 、CD4⁺ 、CD8⁺ 、CD4⁺ /CD8⁺ ) and the human leukocyte antigen DR (HLA-DA/CD14⁺ ) in CD14⁺ monocyte were detected. The incidence of complications and hospitalization time were compared.

The level of blood PCT after treatment in both groups were less than those before treatment, and the effect of the treatment group was better than that of the control group. Compared to pre-treatment, the index of T lymphocyte subsets and HLA-DA/CD14⁺ in both groups increased at day 7, 14 after treatment, and the effect of treatment group was better than that of the control group(both P<0.05). Compared to the control group, the incidence of complications and hospitalization time were reduced significantly (both P<0.05).

The treatment of Tongfu Xiere recipe can reduce the level of blood PCT, the incidence of complications, hospitalization time, and improve the immune function in patients with sepsis.