Efficacy of treatment of mushroom poisoning with liver injury

doi:10.3877/cma.j.issn.2095-9133.2016.01.008

Abstract

Abstract:

Objective

To investigate the clinical characteristics and treatment of mushroom poisoning.

Methods

The clinical characteristics were analyzedin5 cases of mushroom poisoning with liver injury hospitalized after three days. The changes of alanine transaminase(ALT), coagulation function(PT), platelet count(PLT), bilirubin(TBIL) and other parameterswere retrospectively evaluated.

Results

After poisoning, ALT and TBIL increased significantly on the 4th day; In critical patients, ALT peaked on day 4, followed by a rapid decline; TBIL continually increasedand maintained peak state (TBIL>350 μmol, ALT<300 U/L), and "enzyme-jaundice separation" appeared on the 7th day; PT was significantly reduced(PT<20%) on day 4; PLT decreasedrapidly with progression of disease(PLT<50×10⁴/L). The two indexes maintained at a low level in the following days; severe cases progressedto the hepatic coma after 4 days , and died after 10 days.

Conclusion

Forpatients with hepatic type of toadstool toxicosis, the whole gut lavage, blood filling flow or plasma exchange to remove the toxin in time arethe keys to successful rescue.

Key words: mushroom, liver injury, whole gut lavage, blood filling flow, plasma exchange

Guanming Lan, Liya Gong, Minhua Zhong, Zehui Ye. Efficacy of treatment of mushroom poisoning with liver injury[J]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2016, 02(01): 26-29.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhwsyjdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-9133.2016.01.008

https://zhwsyjdzzz.cma-cmc.com.cn/EN/Y2016/V02/I01/26

Figures/Tables 4

References 16

1	Lionete C, Sorodoc L, Simionescu V. Successful treatment of an adult with Amanita phalloides-induced fulminant liver failure with molecular adsorbent recirculating system(MARS)[J]. Rom J Gastroenterol.2005, 14(3): 267-271.
2	孟庆义．毒蕈中毒的临床诊断与治疗[J]，中国临床医生.2012，40(8)：5-8.
3	李毅，于学忠．毒蕈中毒的早期识别与治疗[J]，中国实用内科杂志.2007，27(8)：1172-1173.
4	Sanford T, Golomb M. RNA polymerase 2 from wild type and a-amanitin-resistant strains of Caenorhabditis elegans [J]. J Biol Chem, 1983, 258(21): 12804.
5	Soysal D, Cevik C, Saklamaz A, et al.Coagulation disorders secondary to acute liver failure in amanits phalloides poisoning: a case report[J]. Turk J Gastroenterol, 2006, 17(30): 198-202.
6	黄媛，陈建魁，宋世平，等．肝损害型毒蕈中毒患者凝血指标检测的临床意义[J]．中国卫生检验杂志，2008，18(8)：1571-1572.
7	甘卫敏，张锡刚．血浆置换治疗重度肝损型毒蕈中毒的疗效与时机[J]．中国急救复苏与灾害医学杂志.2012，7(5)：453-455.
8	许宣，丁辉，李丹丹，等．血浆置换治疗四例儿童重度毒蕈中毒的临床分析[J]．中国小儿急救医学，2012，19(4)：419-420.
9	Mendez-Navarro J, Ortiz-Olvera NX, Villegas-Rfos M, et al. Hepatoxicity from ingestion of wild mushrooms of the genus Amanita section Phalloideae collected in Mexico City: two case reports[J]. Ann Hepatol, 2011, 10(4): 568-574.
10	李玥，王琳，杨松，等. AASD急性肝功能衰竭管理建议：2011年更新摘译[J]. 中国肝脏病杂志，2011，4(3)：48-53.
11	Catalina MV, Nunez O, Ponferrada A, et al.Liver failure dure to mushroom poisoning: clinical course and new treatment perspectives [J], Gastroenterol Hepatol, 2003, 26(7): 417-420.
12	张文武．急诊内科学 [M]．北京：人民卫生出版社，2000：568-569.
13	扬宁，肖桂林．灵芝煎剂对鹅膏毒蕈中毒兔肝细胞保护作用的实验研究[J]．中国中西医结合急救杂志，2006，13(9)：273-375.
14	李洁，肖宫，肖桂林．灵芝胶囊治疗鹅膏毒蕈中毒69例临床观察[J]．湖南中医药大学学报 2013，33(5)：71-74.
15	Wei SD, Li ZJ, Liu ZJ, et al.Dexamerthasone attenuates lipopolysaccharide-induced livery by downregulating glucocorticoid-induced tumor necrosis factor receptor ligand in Kupffer cells[J]. Hepatol Res, 2011, 41(10): 989-990.
16	彭小蓉，卢虹旭，刘娟，等．地塞米松对两种急性肝损伤模型小鼠的作用[J]．基础医学与临床，2011，31(6)：717-718.

[1]	Jiangyan Xie, Yafei Wang, Fang He. Pregnancy complicated with thrombotic thrombocytopenic purpura：two cases report and literature review [J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2024, 20(05): 556-563.
[2]	Tongtong Wang, Chunyu Zhu, Yingchu Liu, Guiju Gao. Current situation and mechanism of liver function injury in patients with acquired immunodeficiency syndrome combined with pneumocystis pneumonia treated by Trimethoprim sulfamethoxazole [J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2023, 17(02): 79-83.
[3]	Jie Shu, Lifang Jiang, Ping Zhao. Clinical effect of alternate regional inflow into the liver for hepatectomy in patients with hepatocellular carcinoma and cirrhosis [J]. Chinese Archives of General Surgery(Electronic Edition), 2021, 15(01): 27-31.
[4]	Jiqiang Zhao, Jiquan Zhao, Feng Huo, Zhaohui He. Expression profiling analysis of microRNA in liver and serum of rat models from donation after cardiac death [J]. Chinese Journal of Transplantation(Electronic Edition), 2021, 15(05): 262-269.
[5]	Xi Lu, Tingting Yu, Zhigang Han. Association between CYP2D6 gene polymorphism and liver injury, rash, and diarrhea after targeted therapy inpatients with non-small cell lung cancer [J]. Chinese Journal of Lung Diseases(Electronic Edition), 2020, 13(06): 781-784.
[6]	Wenli Xiu, Chenggang Mao, Chenyu Yang, Qian Dong. Mesenchymal stem cells modified with hepatocyte growth factor gene in the treatment of liver injury [J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2020, 10(06): 373-377.
[7]	Keyan Sun, Jiaxi Mao, Ye Liu, Cong Liu, Wenyuan Guo, Lei Zhang, Fei Teng. Influencing factors of curative effect of plasma exchange in patients with HBV-related acute-on-chronic liver failure waiting for liver transplantation [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2022, 11(03): 252-257.
[8]	Xingyun Wan, Yizhi Chen, Xiangmei Chen. Interpretation of the 2019 clinical practice guidelines on plasma exchange and immunoadsorption from the American Society for Apheresis (8th edition) [J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2021, 10(01): 8-13.
[9]	Xiaoxiao Wang, Jinghui Hu, Jinyun Liu, Junfei Chen, Jingcheng Huang, Xianfu Luo. Value of contrast agent uptake related parameters of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid enhanced magnetic resonance imaging in evaluating the severity of drug induced liver injury in hepatobiliary phase [J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2022, 12(04): 204-209.
[10]	Jiyuan Ren, Zhimin Liu, Chunxing Li, Xuechun Xu, Ruoling Han. Evaluation of therapeutic effects for drug induced liver injury and viral hepatitis using quantitative ARFI technology [J]. Chinese Journal of Clinicians(Electronic Edition), 2022, 16(03): 264-267.
[11]	Xueying Lai, Bin Liu, Xueqin Hu, Haojun Chen. Therapeutic effect of magnesium isoglycyrrhizinate on liver injury induced by paclitaxel and its effect on serum IL-6, IL-10 and TNF-α [J]. Chinese Journal of Clinicians(Electronic Edition), 2020, 14(11): 922-925.
[12]	Qing Tan, Jiangyun Wang, Qifeng Peng, Fang Liu, Yiping Gao, Shiqin Su, Bei Guo, Jianbo Zhao. Follow-up and risk factors analysis of liver function after transjugular intrahepatic portosystemic shunt [J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2022, 10(01): 50-55.
[13]	Jitian Guan, Kezeng You, Yiqun Geng, Shuyi Sun, Lingfeng Lai, Zhiwei Shen, Xiaolei Zhang, Teng Zhou, Huaidong Huang, Lin Yang, Yan Cheng, Shuohua Wu, Zhihong Zhao, Caiyu Zhuang, Renhua Wu. The value of proton magnetic resonance spectroscopy in assessing liver lipid and glucose metabolism alternations in rabbits with acute liver injury [J]. Chinese Journal of Diagnostics(Electronic Edition), 2024, 12(03): 160-165.
[14]	Yan Liu, Shenjie Tang. Research progress on the correlation of intestinal flora with antitubercular agents and antitubercular agents-induced liver injury [J]. Chinese Journal of Diagnostics(Electronic Edition), 2023, 11(02): 82-86.
[15]	Yinjie Zhang, Zhihuai Wang, Xuelin Tang, Peng Gao, Chunfu Zhu, Zhongzhi Jia, Xihu Qin, Maoxing Yue. Therapeutic effect of a high dosage of vitamin B₆ on hepatic stress injury [J]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2023, 09(05): 285-292.

Please choose a citation manager

Content to export