The protective effect of ischemia processing on pressure sores induced by ischemia reperfusion injury in rats

doi:10.3877/cma.j.issn.2095-9133.2018.01.006

Abstract

Abstract:

Objective

To compare the protective effect of different treatment methods on skin and subcutaneous tissue of rats with pressure sores induced by ischemia reperfusion injuryand to provide a theoretical basis for the clinical judgment of the stage of pressure ulcer and its intervention results.

Methods

100 rats were randomly divided into five groups including control group, ischemia-reperfusion group, and ischemic pretreatment group with 20 rats in each group. By establishing ischemia pre-processing model of rats, observing the stage of pressure ulcer and testing free radical, the degree of ischemia reperfusion injury can be judged.

Results

The incidence of pressure ulcer at stage I in group RI and group IPC are 100%. The serum concentrations of nitric oxide and nitric malondialdehyde in group IPC were higher than that in group S but lower than that in group RI. The activity of superoxide dismutase in group IPC were higher than that in group RI but lower than that in group S.

Conclusions

The ischemia pre-processing on pressure ulcer has a protective effect on ischemia reperfusion injury.

Key words: Pressure ulcer, Ischemia-reperfusion Injury, Ischemic postconditioning, Superoxide dismutase, Nitric oxide, Malondialdehyde

Yan Zhen, Huajun Wang, Weimin Yi. The protective effect of ischemia processing on pressure sores induced by ischemia reperfusion injury in rats[J]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2018, 04(01): 29-32.

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Figures/Tables 4

References 12

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项目	对比组
项目	S组与IR组	S组与IPC组	S组与I-postC组	S组与IPC＋I-postC组	IR组与IPC组
H	39.000	39.000	39.000	39.000	0.000
ν	1	1	1	1	1
P值	<0.001	<0.001	<0.001	<0.001	1.000
结果	P<α′	P<α′	P<α′	P<α′	P<α′
项目	对比组
项目	IR组与I-postC组	IR组与IPC＋I-postC组	IPC组与I-postC组	IPC组与IPC＋I-postC组	I-postC组与IPC＋I-postC组
H	0.000	0.000	0.000	0.000	0.000
ν	1	1	1	1	1
P值	1.000	1.000	1.000	1.000	1.000
结果	P<α′	P<α′	P<α′	P<α′	P<α′

项目	对比组
项目	S组与IR组	S组与IPC组	S组与I-postC组	S组与IPC＋I-postC组	IR组与IPC组
H	39.000	39.000	39.000	39.000	0.000
ν	1	1	1	1	1
P值	<0.001	<0.001	<0.001	<0.001	1.000
结果	P<α′	P<α′	P<α′	P<α′	P<α′
项目	对比组
项目	IR组与I-postC组	IR组与IPC＋I-postC组	IPC组与I-postC组	IPC组与IPC＋I-postC组	I-postC组与IPC＋I-postC组
H	0.000	0.000	0.000	0.000	0.000
ν	1	1	1	1	1
P值	1.000	1.000	1.000	1.000	1.000
结果	P<α′	P<α′	P<α′	P<α′	P<α′

组别	SOD(I/mL)	MDA(nml/mL)	NO(nml/L)
S组	127.41±5.48	4.20±0.78	30.23±0.84
IR组	117.48±4.17	5.58±0.39	40.55±1.08
IPC组	122.38±4.31	5.29±0.21	40.48±0.93
I-postC组	122.68±5.51	5.23±0.40	40.12±1.51
IPC＋I-postC组	121.97±7.33	5.27±0.38	40.19±1.33
F值	24.440	2.134	9.452
P值	<0.05	<0.05	<0.05

组别	SOD(I/mL)	MDA(nml/mL)	NO(nml/L)
S组	127.41±5.48	4.20±0.78	30.23±0.84
IR组	117.48±4.17	5.58±0.39	40.55±1.08
IPC组	122.38±4.31	5.29±0.21	40.48±0.93
I-postC组	122.68±5.51	5.23±0.40	40.12±1.51
IPC＋I-postC组	121.97±7.33	5.27±0.38	40.19±1.33
F值	24.440	2.134	9.452
P值	<0.05	<0.05	<0.05

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