Abstract:
Objective To investigate the relationship between the expression of neuron specific enolase (NSE) in serum and the severity and prognosis of patients with brain injury caused by different causes.
Methods A retrospective analysis of 38 patients admitted to our intensive care unit from June 2018 to June 2019 was performed, including 28 males and 10 females, aged 25-87 years with an average age of (53.9 ± 13.3) years.The patients who met the admission criteria were GCS scores. The patients were divided into three groups according to the GCS score: mild and intermediate group (group A), severe group (group B) and very severe group (group C). There were 10 cases in group A (GCS 9-15 points), 14 cases in group B (GCS 6-8 points), and 14 cases in group C (GCS 3 to 5 points). The above grouped patients were scored APACHE II respectively. Serum NSE levels were detected.
Results The serum NSE levels of all patients with craniocerebral injury were higher than those of the moderately severe group and the mild group (P<0.05). The higher the NSE level, the higher the APACHE II score and the higher the mortality rate.
Conclusion The expression of neuron-specific enolase can be used as a laboratory index to evaluate the degree of craniocerebral injury and is negatively correlated with the prognosis of patients.
Key words:
Phosphopyruvate hydratase,
Craniocerebral injury,
Neurological function,
APACHEⅡ score
Yufeng He. Values of neuron-specific enolase in patients with craniocerebral injury in prognostic assessment of neurological function[J]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2019, 05(06): 348-350.