To observe the effect of early mild hypothermia induced by ice saline on the clinical efficacy of patients after cardiopulmonary resuscitation (CPR), and to provide scientific methods for improving the clinical efficacy after cardiopulmonary resuscitation (CPR).

From March 2015 to April 2018, 40 patients with "cardiac arrest" admitted to the emergency department of Nanjing Pukou hospital were selected as the research objects. There were 33 males and 7 females, aged 35-79 years [(56.2±9.8) years]. The patients were randomly divided into study group (n=20, male 17, female 3) and control group (n=20, male 16, female 4). The control group was only given conventional resuscitation therapy, while the study group was added with 0.9% sodium chloride injection at 4 ℃ through (peripheral or central) venous or medullary cavity channels to induce mild hypothermia, combined with external cooling and drug cooling to maintain mild hypothermia, The rectal temperature and the time to reach the standard immediately and 1 h after the return of spontaneous circulation (ROSC) were compared between the two groups. The Glasgow Coma Scale (GCS) and arterial blood lactic acid level were compared immediately, 4 h, 24 h, 48 h, 72 h after ROSC, and the effect of mild hypothermia on the efficacy of the two groups was evaluated.

The rectal temperature of the study group was (34.2±0.4)℃ and that of the control group was (36.8±0.5)℃ 1 h after ROSC, and the difference between the two groups was statistically significant (t=18.3, P<0.05). The GCS scores of the two groups at 48 h and 72 h after ROSC were higher than before. 48 h The GCS score of the study group was(8.01±1.12), and that of the control group was(6.76±1.85). The difference between the two groups was statistically significant (t=2.72, P<0.05). The GCS score of the study group at 72 h was(9.06±1.78), and that of the control group was(7.47±1.22). The difference between the two groups was statistically significant (t=3.41, P<0.05). The arterial blood lactate levels at 4 h, 24 h, 48 h and 72 h after ROSC in the two groups showed a downward trend, and at each time point, the levels of arterial blood lactic acid in the study group were(5.52±1.65)mmol/L, (3.96±1.71)mmol/L, (2.09±1.66)mmol/L, (1.77±1.59)mmol/L; those in the control group were(6.71±1.36)mmol/L, (5.33±1.27)mmol/L, (4.16±1.95)mmol/L and (2.06±1.72)mmol/L, respectively The difference was statistically significant (P<0.05).

The mild hypothermia therapy combined with ice saline induction and external and drug cooling in the early stage after CPR has good clinical effect on patients with cardiac arrest, which is worthy of clinical application.