The effect and safety of amiodaronum in the treatmentof patients with tachyarrhythmia in the process of pre-hospital care

doi:10.3877/cma.j.issn.2095-9133.2018.02.007

Abstract

Abstract:

Objective

To investigate the effect and safety of amiodaronum in the treatment of patients with tachyarrhythmia(TH)before hospitalization.

Methods

From January 2012 to December 2016, 942 patients with tachyarrhythmias who were treated on-site at the emergency center of Jiaozhou People’s Hospital Emergency Center were selected as subjects. According to the treatment methods, they were divided into control groups(471 cases)and observation group(471 cases). The observation group consisted of 269 males and 202 females, aged 35 to 81 years, with an average age of (60.8±14.2) years . The control group consisted of 270 males and 201 female, aged 34 to 83 years, with an average age of (60.9±14.4) years. The control group was treated with conventional method. The observation group was treated with achievable intravenous infusion of amiodaronum before hospital on the basis of the conventional method. The patient leaving the hospital emergency room is regarded as the study endpoint and the patient’s heart rate(HR)before and after treatment was observed. Changes in hemodynamic parameters such as systolic blood pressure(SBP)and diastolic blood pressure (DBP), efficacy, and occurrence of adverse drug reactions were obseved.

Results

After treatment, HR(75.3±4.6)/min, SBP(102.7±12.2)mmHg and DBP(73.2±5.4) mmHg were lower in the observation group than those in the control group HR(111.2±4.9)/min, SBP(114.3±13.1) mmHg and DBP(80.4±6.4)mmHg, which were statistically significant (P<0.01). The effective rate in the observation group was 81.53% after treatment and was higher than that in the control group (72.40%). The difference was statistically significant (P<0.05). There were no adverse drug reactions in the control group. In the observation group, 471 patients were treated before the hospital, with 373 effective cases(79.2%)and 98 ineffective cases(20.8%). 22 cases(4.7%)experienced adverse drug reactions, wtih low blood pressure and sinus bradycardia.

Conclusions

The curative effect and safety of the pre-hospital emergency treatment of TH patients in the pre-hospital emergency treatment are worthy of recognition. It is suggested that amiodaronum should be used as the first choice for the pre-hospital care of patients with Tachyarrhythmia.

Key words: Tachyarrhythmia, amiodaronum, pre-hospital care

Pinping Yang, Lei Tai. The effect and safety of amiodaronum in the treatmentof patients with tachyarrhythmia in the process of pre-hospital care[J]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2018, 04(02): 92-96.

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组别		HR(次/min)	SBP(mmHg)	DBP(mmHg)
观察组		?	?	?
?	治疗前	127.1±6.8	126.5±13.7	89.3±8.0
?	治疗后	75.3±4.6	102.7±12.2	73.2±5.4
?	t值	41.31	12.99	18.92
?	P值	<0.05	<0.05	<0.05
对照组		?	?	?
?	治疗前	127.0±6.7	125.6±13.6	89.4±8.1
?	治疗后	111.2±4.9	114.3±13.1	80.4±6.4
?	t值	76.89	28.16	36.20
?	P值	<0.05	<0.05	<0.05

组别		HR(次/min)	SBP(mmHg)	DBP(mmHg)
观察组		?	?	?
?	治疗前	127.1±6.8	126.5±13.7	89.3±8.0
?	治疗后	75.3±4.6	102.7±12.2	73.2±5.4
?	t值	41.31	12.99	18.92
?	P值	<0.05	<0.05	<0.05
对照组		?	?	?
?	治疗前	127.0±6.7	125.6±13.6	89.4±8.1
?	治疗后	111.2±4.9	114.3±13.1	80.4±6.4
?	t值	76.89	28.16	36.20
?	P值	<0.05	<0.05	<0.05

类型	例数	有效	无效
观察组	471	384(81.53)	87(18.47)
对照组	471	341(72.40)	130(27.60)
χ²值	?	5.397	6.194
P值	?	<0.05	<0.05

类型	例数	有效	无效
观察组	471	384(81.53)	87(18.47)
对照组	471	341(72.40)	130(27.60)
χ²值	?	5.397	6.194
P值	?	<0.05	<0.05

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