Clinical effect of standard large bone flap craniotomy combined with mild hypothermia in treatment of severe craniocerebral injury

doi:10.3877/cma.j.issn.2095-9133.2016.02.009

Abstract

Abstract:

Objective

To study the clinical effect of standard large bone flap craniotomy combined with mild hypothermia for severe craniocerebral injury.

Methods

Fifty cases of severe craniocerebral injury patients were collected from April 2014 to January 2015 in our hospital, which were randomly divided into surgical group and combined treatment group.The patients in surgical group received standard large bone flap craniotomy for hematoma removal, and the patients in combined treatment group received standard large bone flap craniotomy plus mild hypothermia treatment.The intracranial pressure and prognosis before and after treatment in two groups were compared respectively.

Results

The mortality of combined group and surgical group were 20% and 32%, respectively, with lowermortality of combined group group.After treatment, the intracranial pressure was decreased in two group, with more significant decrease in thecombined group(t=8.98, P<0.05). The Bederson score [(1.48±0.34)points] and apoptosis cell number (59±12) ofcombined group were lower than that of the surgical group [(2.79±0.28)pints and 116±19](t=8.765, P<0.05).

Conclusion

For patients with severe craniocerebral injury, standard large bone flap craniotomy combined with mild hypothermia can rapidly reduce intracranial pressure, improve the prognosis and is worthy of popularization.

Key words: Standard large bone flap craniotomy hematoma removal, Mild hypothermia, Severe brain injury, Clinical effect

Kun Wang, Dongwei Liu, Ping Yuan, Bing Liu, Jianyong Chen, Guanglei Liu, Peng Zhao, Peng Fan. Clinical effect of standard large bone flap craniotomy combined with mild hypothermia in treatment of severe craniocerebral injury[J]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2016, 02(02): 104-106.

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References 10

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组别	例数	治疗前	治疗后
手术联合亚低温组	25	5.52±1.51	2.13±0.54
手术组	25	5.22±1.72	3.24±0.64
t值	－	1.83	8.98
P值	－	>0.05	<0.05

组别	例数	治疗前	治疗后
手术联合亚低温组	25	5.52±1.51	2.13±0.54
手术组	25	5.22±1.72	3.24±0.64
t值	－	1.83	8.98
P值	－	>0.05	<0.05

组别	例数	Bederson评分	凋亡细胞
手术联合亚低温组	25	1.48±0.34^a	59±12^a
手术组	25	2.79±0.28	116±19
t值	－	9.41	8.02
P值	－	<0.05	<0.05

组别	例数	Bederson评分	凋亡细胞
手术联合亚低温组	25	1.48±0.34^a	59±12^a
手术组	25	2.79±0.28	116±19
t值	－	9.41	8.02
P值	－	<0.05	<0.05

组别	例数	基本恢复	中度残疾	重度残疾	死亡
手术联合亚低温组	25	12(48.0)	6(24.0)	2(4.0)	5(20.0)
手术组	25	9(36.0)	5(20.0)	3(12.0)	8(32.0)
χ²值	8.24
P值	<0.05

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